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Research ArticleSpine

Characterization of Peripheral Nerve Sheath Tumors with 3T Proton MR Spectroscopy

L.M. Fayad, X. Wang, J.O. Blakeley, D.J. Durand, M.A. Jacobs, S. Demehri, T.K. Subhawong, T. Soldatos and P.B. Barker
American Journal of Neuroradiology May 2014, 35 (5) 1035-1041; DOI: https://doi.org/10.3174/ajnr.A3778
L.M. Fayad
aFrom The Russell H. Morgan Department of Radiology and Radiological Science (L.M.F., X.W., D.J.D., S.D., M.A.J., P.B.B.)
bOrthopedic Surgery (L.M.F.)
cOncology (L.M.F., M.A.J.), The Johns Hopkins Hospital Comprehensive Neurofibromatosis Center
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X. Wang
aFrom The Russell H. Morgan Department of Radiology and Radiological Science (L.M.F., X.W., D.J.D., S.D., M.A.J., P.B.B.)
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J.O. Blakeley
dDepartment of Neurology (J.O.B.), The Johns Hopkins University School of Medicine, Baltimore, Maryland
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D.J. Durand
aFrom The Russell H. Morgan Department of Radiology and Radiological Science (L.M.F., X.W., D.J.D., S.D., M.A.J., P.B.B.)
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M.A. Jacobs
aFrom The Russell H. Morgan Department of Radiology and Radiological Science (L.M.F., X.W., D.J.D., S.D., M.A.J., P.B.B.)
cOncology (L.M.F., M.A.J.), The Johns Hopkins Hospital Comprehensive Neurofibromatosis Center
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S. Demehri
aFrom The Russell H. Morgan Department of Radiology and Radiological Science (L.M.F., X.W., D.J.D., S.D., M.A.J., P.B.B.)
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T.K. Subhawong
eDepartment of Radiology (T.K.S.), University of Miami Miller School of Medicine, Miami, Florida
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T. Soldatos
fResearch Unit of Radiology and Medical Imaging (T.S.), National and Capodestrian University of Athens, Evgenidion Hospital, Athens, Greece.
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P.B. Barker
aFrom The Russell H. Morgan Department of Radiology and Radiological Science (L.M.F., X.W., D.J.D., S.D., M.A.J., P.B.B.)
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REFERENCES

  1. 1.↵
    1. Kransdorf MJ
    . Benign soft-tissue tumors in a large referral population: distribution of specific diagnoses by age, sex, and location. AJR Am J Roentgenol 1995;164:395–402
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Kransdorf MJ,
    2. Murphey MD,
    3. Smith SE
    . Imaging of soft tissue neoplasms in the adult: benign tumors. Semin Musculoskelet Radiol 1999;3:21–38
    CrossRefPubMed
  3. 3.↵
    1. Murphey MD,
    2. Kransdorf MJ,
    3. Smith SE
    . Imaging of soft tissue neoplasms in the adult: malignant tumors. Semin Musculoskelet Radiol 1999;3:39–58
    CrossRefPubMed
  4. 4.↵
    1. Jee WH,
    2. Oh SN,
    3. McCauley T,
    4. et al
    . Extraaxial neurofibromas versus neurilemmomas: discrimination with MRI. AJR Am J Roentgenol 2004;183:629–33
    CrossRefPubMed
  5. 5.↵
    1. Bhargava R,
    2. Parham DM,
    3. Lasater OE,
    4. et al
    . MR imaging differentiation of benign and malignant peripheral nerve sheath tumors: use of the target sign. Pediatr Radiol 1997;27:124–29
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Li CS,
    2. Huang GS,
    3. Wu HD,
    4. et al
    . Differentiation of soft tissue benign and malignant peripheral nerve sheath tumors with magnetic resonance imaging. Clin Imaging 2008;32:121–27
    CrossRefPubMed
  7. 7.↵
    1. Matsumine A,
    2. Kusuzaki K,
    3. Nakamura T,
    4. et al
    . Differentiation between neurofibromas and malignant peripheral nerve sheath tumors in neurofibromatosis 1 evaluated by MRI. J Cancer Res Clin Oncol 2009;135:891–900
    CrossRefPubMed
  8. 8.↵
    1. Wasa J,
    2. Nishida Y,
    3. Tsukushi S,
    4. et al
    . MRI features in the differentiation of malignant peripheral nerve sheath tumors and neurofibromas. AJR Am J Roentgenol 2010;194:1568–74
    CrossRefPubMed
  9. 9.↵
    1. Bensaid B,
    2. Giammarile F,
    3. Mognetti T,
    4. et al
    . Utility of 18 FDG positron emission tomography in detection of sarcomatous transformation in neurofibromatosis type 1. Ann Dermatol Venereol 2007;134:735–41
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Bredella MA,
    2. Torriani M,
    3. Hornicek F,
    4. et al
    . Value of PET in the assessment of patients with neurofibromatosis type 1. AJR Am J Roentgenol 2007;189:928–35
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Ferner RE,
    2. Golding JF,
    3. Smith M,
    4. et al
    . [18F]2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) as a diagnostic tool for neurofibromatosis 1 (NF1) associated malignant peripheral nerve sheath tumours (MPNSTs): a long-term clinical study. Ann Oncol 2008;19:390–94
    Abstract/FREE Full Text
  12. 12.↵
    1. Karabatsou K,
    2. Kiehl TR,
    3. Wilson DM,
    4. et al
    . Potential role of 18fluorodeoxyglucose-positron emission tomography/computed tomography in differentiating benign neurofibroma from malignant peripheral nerve sheath tumor associated with neurofibromatosis 1. Neurosurgery 2009;65:A160–70
    CrossRefPubMed
  13. 13.↵
    1. Warbey VS,
    2. Ferner RE,
    3. Dunn JT,
    4. et al
    . [18F]FDG PET/CT in the diagnosis of malignant peripheral nerve sheath tumours in neurofibromatosis type-1. Eur J Nucl Med Mol Imaging 2009;36:751–57
    CrossRefPubMed
  14. 14.↵
    1. Fayad LM,
    2. Jacobs MA,
    3. Wang X,
    4. et al
    . Musculoskeletal tumors: how to use anatomic, functional, and metabolic MR techniques. Radiology 2012;265:340–56
    CrossRefPubMed
  15. 15.↵
    1. Hascalik S,
    2. Celik O,
    3. Erdem G,
    4. et al
    . Proton magnetic resonance spectroscopy findings of a sacrococcygeal schwannoma. Int J Gynecol Cancer 2006;16 Suppl 1:344–48
    CrossRef
  16. 16.↵
    1. Qi ZH,
    2. Li CF,
    3. Li ZF,
    4. et al
    . Preliminary study of 3T 1H MR spectroscopy in bone and soft tissue tumors. Chin Med J (Engl) 2009;122:39–43
    PubMed
  17. 17.↵
    1. Lee CW,
    2. Lee JH,
    3. Kim DH,
    4. et al
    . Proton magnetic resonance spectroscopy of musculoskeletal lesions at 3 T with metabolite quantification. Clin Imaging 2010;34:47–52
    CrossRefPubMed
  18. 18.↵
    1. Subhawong TK,
    2. Wang X,
    3. Durand DJ,
    4. et al
    . Proton MR spectroscopy in metabolic assessment of musculoskeletal lesions. AJR Am J Roentgenol 2012;198:162–72
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Wang CK,
    2. Li CW,
    3. Hsieh TJ,
    4. et al
    . Characterization of bone and soft-tissue tumors with in vivo 1H MR spectroscopy: initial results. Radiology 2004;232:599–605
    CrossRefPubMed
  20. 20.↵
    1. Fayad LM,
    2. Wang X,
    3. Salibi N,
    4. et al
    . A feasibility study of quantitative molecular characterization of musculoskeletal lesions by proton MR spectroscopy at 3 T. AJR Am J Roentgenol 2010;195:W69–75
    CrossRefPubMed
  21. 21.↵
    1. Fayad LM,
    2. Bluemke DA,
    3. McCarthy EF,
    4. et al
    . Musculoskeletal tumors: use of proton MR spectroscopic imaging for characterization. J Magn Reson Imaging 2006;23:23–28
    CrossRefPubMed
  22. 22.↵
    1. Fayad LM,
    2. Barker PB,
    3. Jacobs MA,
    4. et al
    . Characterization of musculoskeletal lesions on 3-T proton MR spectroscopy. AJR Am J Roentgenol 2007;188:1513–20
    CrossRefPubMed
  23. 23.↵
    1. Fayad LM,
    2. Barker PB,
    3. Bluemke DA
    . Molecular characterization of musculoskeletal tumors by proton MR spectroscopy. Semin Musculoskelet Radiol 2007;11:240–45
    CrossRefPubMed
  24. 24.↵
    1. Benz MR,
    2. Czernin J,
    3. Dry SM,
    4. et al
    . Quantitative F18-fluorodeoxyglucose positron emission tomography accurately characterizes peripheral nerve sheath tumors as malignant or benign. Cancer 2010;116:451–58
    CrossRefPubMed
  25. 25.↵
    1. Bonekamp D,
    2. Smith MA,
    3. Zhu H,
    4. et al
    . Quantitative SENSE-MRSI of the human brain. Magn Reson Imaging 2010;28:305–13
    CrossRefPubMed
  26. 26.↵
    1. Natt O,
    2. Bezkorovaynyy V,
    3. Michaelis T,
    4. et al
    . Use of phased array coils for a determination of absolute metabolite concentrations. Magn Reson Med 2005;53:3–8
    CrossRefPubMed
  27. 27.↵
    1. Fayad LM,
    2. Salibi N,
    3. Wang X,
    4. et al
    . Quantification of muscle choline concentrations by proton MR spectroscopy at 3 T: technical feasibility. AJR Am J Roentgenol 2010;194:W73–79
    CrossRefPubMed
  28. 28.↵
    1. Perrin RG,
    2. Guha A
    . Malignant peripheral nerve sheath tumors. Neurosurg Clin N Am 2004;15:203–16
    CrossRefPubMed
  29. 29.↵
    1. Kransdorf MJ
    . Malignant soft-tissue tumors in a large referral population: distribution of diagnoses by age, sex, and location. AJR Am J Roentgenol 1995;164:129–34
    CrossRefPubMedWeb of Science
  30. 30.↵
    1. Glunde K,
    2. Artemov D,
    3. Penet MF,
    4. et al
    . Magnetic resonance spectroscopy in metabolic and molecular imaging and diagnosis of cancer. Chem Rev 2010;110:3043–59
    CrossRefPubMedWeb of Science
  31. 31.↵
    1. Thomas L,
    2. Richards M,
    3. Mort M,
    4. et al
    . Assessment of the potential pathogenicity of missense mutations identified in the GTPase-activating protein (GAP)-related domain of the neurofibromatosis type-1 (NF1) gene. Hum Mutat 2012;33:1687–96
    CrossRefPubMed
  32. 32.↵
    1. Beert E,
    2. Brems H,
    3. Daniëls B,
    4. et al
    . Atypical neurofibromas in neurofibromatosis type 1 are premalignant tumors. Genes Chromosomes Cancer 2011;50:1021–32
    CrossRefPubMed
  33. 33.↵
    1. Murphey MD,
    2. Smith WS,
    3. Smith SE,
    4. et al
    . From the archives of the AFIP. Imaging of musculoskeletal neurogenic tumors: radiologic-pathologic correlation. Radiographics 1999;19:1253–80
    CrossRefPubMedWeb of Science
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American Journal of Neuroradiology: 35 (5)
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Cite this article
L.M. Fayad, X. Wang, J.O. Blakeley, D.J. Durand, M.A. Jacobs, S. Demehri, T.K. Subhawong, T. Soldatos, P.B. Barker
Characterization of Peripheral Nerve Sheath Tumors with 3T Proton MR Spectroscopy
American Journal of Neuroradiology May 2014, 35 (5) 1035-1041; DOI: 10.3174/ajnr.A3778

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Characterization of Peripheral Nerve Sheath Tumors with 3T Proton MR Spectroscopy
L.M. Fayad, X. Wang, J.O. Blakeley, D.J. Durand, M.A. Jacobs, S. Demehri, T.K. Subhawong, T. Soldatos, P.B. Barker
American Journal of Neuroradiology May 2014, 35 (5) 1035-1041; DOI: 10.3174/ajnr.A3778
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