Article Figures & Data
Figures
- Fig. 1.
Overview of synthetic tissue mapping. A, MR quantification scan of an axial section of the brain results in a pixel-wise measurement of the R1 and R2 relaxation rates and PD. Data of the ROI (gray box) is plotted on the R1-R2 projection of this space in B. CSF, gray matter, and WM have unique combinations of R1, R2, and PD and thus a fixed position in R1-R2-PD space (circles), containing 100% of the indicated tissue types. Partial volume data are located between these identified positions. For CSF, the partial volume values are shown as the white gradient. All voxels containing CSF, gray matter, or WM are included in the ICV mask, followed by a region growing algorithm to ensure that the ICV is represented as a continuous volume (C). D, Within the ICV mask, the partial volume CSF is calculated. The brain parenchymal volume corresponds to the ICV minus the total CSF volume. Finally, the BPF is found as the ratio between brain parenchymal volume and ICV.
- Fig. 2.
BPF in relation to age, disease duration, and functional impairment. BPF of the patients with relapsing onset MS (relapsing-remitting MS and secondary-progressive MS) plotted as a function of (A) age (r2 = 0.24; P < .001), (B) disease duration (r2 = 0.33; P < .001), and (C) Expanded Disability Status Scale (r2 = 0.32; P < .001).
- Fig. 3.
Comparison between SyMap and QBrain. A, BPF values calculated with the SyMap method plotted against the value calculated with the manual reference method for the same subject. B, Difference in BPF between the methods plotted for each subject against the mean BPF for each subject as a Bland-Altman plot. Mean difference (solid line), limits of agreement (dotted lines, mean difference ± 1.96 SD).
- Fig. 4.
Reproducibility of SyMap. BPF of each of the repeated scans plotted for each of the 6 subjects. Coefficient of variation = 0.45% (SE = 0.068%).
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