Article Figures & Data
Figures
- Fig 1.
A, Coronal, sagittal, and axial views of the cervical cord template created as average of the 83 healthy subjects included in the study. B, Coronal, sagittal, and axial sections (at different cervical cord levels) of the corresponding color-coded normalized region-label mask reporting the 24 reference anatomic regions. Areas outside the cervical cord were masked out.
- Fig 2.
Coronal, sagittal, and axial views of the mean cord tissue probability map for the 83 study subjects.
- Fig 3.
Significant clusters of correlation between cervical cord atrophy and subject age, corrected for the possible confounding effects of sex and total cord volume (P < .001, uncorrected for multiple comparisons; cluster extent, k ≥ 20) with the different smoothing options applied to our cervical cord masks. A, Isotropic Gaussian kernels with FWHM ranging from 0.5 to 2.5 mm3. B, Anisotropic Gaussian kernels with FWHM ranging from 0.5 × 0.5 × 1 mm3 to 2 × 2 × 3 mm3.
Tables
Significant clusters of correlation between cord atrophy and aging revealed by voxel-based analyses with different smoothing optionsa
Smoothing-Kernel Width Peak Locations P Value T Value κ R % Voxels % Voxels AP R-L 0.5 × 0.5 × 0.5 mm3 AR-C5 <.001 3.9 31 −0.41 31/0 6/25 1 × 1 × 1 mm3 AR-C4 <.001 3.8 32 −0.40 73/0 8/65 AR-C5 <.001 3.9 41 −0.40 1.5 × 1.5 × 1.5 mm3 AR-C4 <.001 3.7 47 −0.39 103/0 16/87 AR-C5 <.001 3.8 56 −0.40 2 × 2 × 2 mm3 AR-C4 <.001 4.2 76 −0.44 140/0 26/115 AL-C5 <.001 4.1 64 −0.42 2.5 × 2.5 × 2.5 mm3 AL-C4 <.001 4.5 91 −0.46 149/0 33/116 AL-C5 <.001 4.1 58 −0.42 0.5 × 0.5 × 1 mm3 AR-C5 <.001 3.9 29 −0.40 29/0 5/24 1 × 1 × 2 mm3 AR-C4 <.001 3.8 42 −0.39 89/0 13/76 AR-C5 <.001 3.8 47 −0.40 1.5 × 1.5 × 2.5 mm3 PR-C1/C2 <.001 3.6 20 −0.37 117/20 23/114 AR-C4 <.001 3.7 52 −0.39 AR-C5 <.001 3.8 65 −0.40 2 × 2 × 3 mm3 AR C4 <.001 4.1 150 −0.43 150/0 35/115 AL C5 <.001 4.3 −0.45 -
↵a Multiple regression with age corrected for sex and total cord volume, P < .001; uncorrected for multiple comparisons, cluster extent κ ≥ 20.
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