Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleSpine Imaging and Spine Image-Guided Interventions
Open Access

A 3T MR Imaging Investigation of the Topography of Whole Spinal Cord Atrophy in Multiple Sclerosis

J.P. Klein, A. Arora, M. Neema, B.C. Healy, S. Tauhid, D. Goldberg-Zimring, C. Chavarro-Nieto, J.M. Stankiewicz, A.B. Cohen, G.J. Buckle, M.K. Houtchens, A. Ceccarelli, E. Dell'Oglio, C.R.G. Guttmann, D.C. Alsop, D.B. Hackney and R. Bakshi
American Journal of Neuroradiology June 2011, 32 (6) 1138-1142; DOI: https://doi.org/10.3174/ajnr.A2459
J.P. Klein
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. Arora
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. Neema
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
B.C. Healy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. Tauhid
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D. Goldberg-Zimring
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C. Chavarro-Nieto
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J.M. Stankiewicz
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A.B. Cohen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
G.J. Buckle
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M.K. Houtchens
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. Ceccarelli
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
E. Dell'Oglio
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C.R.G. Guttmann
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D.C. Alsop
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D.B. Hackney
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R. Bakshi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Figures & Data

Figures

  • Fig 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 1.

    Representative spinal MR imaging scans and segmentation. T2-weighted fast spin-echo axial images obtained at 3T of the upper cervical (A), lower cervical (C), and thoracic (E) spinal cord are shown. High contrast between the spinal cord (hypointense) and the surrounding CSF (hyperintense) is noted. Semiautomated spinal cord contour maps are shown for the identical sections in B, D, and F. The patient is a 29-year-old woman with RRMS of 7 years' disease duration on treatment with interferon β-1a at the time of imaging, with no physical disability (EDSS score of 0).

  • Fig 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 2.

    Spinal cord volume (plotted as volume/section/ICV) segmented by vertebral level. Group comparison P values with and without correction for multiple statistical tests are presented in On-line Tables 2 and 3. Bar heights represent means; error bars represent SDs.

  • Fig 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 3.

    Whole spinal cord volume (plotted as volume/section/ICV). Whole spinal cord volume is 12.6% smaller in PPMS/SPMS compared with RRMS/CIS. No significant difference in whole spinal cord volume is detected between RRMS/CIS and controls, PPMS/SPMS and controls, or all MS and controls. Group comparison P values with and without correction for multiple statistical tests are presented in On-line Tables 2 and 3. Bar heights represent means; error bars represent SDs.

PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 32 (6)
American Journal of Neuroradiology
Vol. 32, Issue 6
1 Jun 2011
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
A 3T MR Imaging Investigation of the Topography of Whole Spinal Cord Atrophy in Multiple Sclerosis
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
J.P. Klein, A. Arora, M. Neema, B.C. Healy, S. Tauhid, D. Goldberg-Zimring, C. Chavarro-Nieto, J.M. Stankiewicz, A.B. Cohen, G.J. Buckle, M.K. Houtchens, A. Ceccarelli, E. Dell'Oglio, C.R.G. Guttmann, D.C. Alsop, D.B. Hackney, R. Bakshi
A 3T MR Imaging Investigation of the Topography of Whole Spinal Cord Atrophy in Multiple Sclerosis
American Journal of Neuroradiology Jun 2011, 32 (6) 1138-1142; DOI: 10.3174/ajnr.A2459

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
A 3T MR Imaging Investigation of the Topography of Whole Spinal Cord Atrophy in Multiple Sclerosis
J.P. Klein, A. Arora, M. Neema, B.C. Healy, S. Tauhid, D. Goldberg-Zimring, C. Chavarro-Nieto, J.M. Stankiewicz, A.B. Cohen, G.J. Buckle, M.K. Houtchens, A. Ceccarelli, E. Dell'Oglio, C.R.G. Guttmann, D.C. Alsop, D.B. Hackney, R. Bakshi
American Journal of Neuroradiology Jun 2011, 32 (6) 1138-1142; DOI: 10.3174/ajnr.A2459
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • Abbreviations
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • What are the gray and white matter volumes of the human spinal cord?
  • Clinically relevant cranio-caudal patterns of cervical cord atrophy evolution in MS
  • Cervical spinal cord atrophy: An early marker of progressive MS onset
  • Multicenter Validation of Mean Upper Cervical Cord Area Measurements from Head 3D T1-Weighted MR Imaging in Patients with Multiple Sclerosis
  • Voxel-wise mapping of cervical cord damage in multiple sclerosis patients with different clinical phenotypes
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Management Outcomes For VO Spine Biopsy
  • Characteristics of SIH Type I Culprit Lesions
  • Advanced Imaging of Type 2 Spinal CSF Leaks
Show more Spine Imaging and Spine Image-Guided Interventions

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire