Age-Related Metabolic Profiles in Cognitively Healthy Elders: Results from a Voxel-Based [¹⁸F]Fluorodeoxyglucose–Positron-Emission Tomography Study with Partial Volume Effects Correction

SPMs of the whole-brain search of significant negative correlations between relative metabolism and age in the overall sample of cognitively healthy elderly individuals (n = 55) at the z > 3.09 threshold, corresponding to P < .001, with an extent threshold of 100 voxels. A, Foci of negative correlations with the inclusion of the FCHDR group and number of APOE ε4 alleles as covariates of no interest in the analysis of PET images uncorrected for PVE. B, Lack of foci of negative correlations without the inclusion of covariates of no interest in the analysis of PET images corrected for PVE.