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Research ArticleBrain
Open Access

Brain Iron Quantification in Mild Traumatic Brain Injury: A Magnetic Field Correlation Study

E. Raz, J.H. Jensen, Y. Ge, J.S. Babb, L. Miles, J. Reaume, R.I. Grossman and M. Inglese
American Journal of Neuroradiology November 2011, 32 (10) 1851-1856; DOI: https://doi.org/10.3174/ajnr.A2637
E. Raz
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J.H. Jensen
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Y. Ge
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J.S. Babb
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L. Miles
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J. Reaume
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R.I. Grossman
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M. Inglese
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    Fig 1.

    Representative of the ROIs drawn on 2 sample T2 images at the level of basal ganglia and centrum semiovale.

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    Fig 2.

    Representative MFC color maps and correspondent T2 images of 2 brain sections at the level of globus pallidus and thalamus in a 42-year-old male patient with mTBI. The patient complained of neck stiffness; his GCS score was 15, and the conventional MR imaging scan was normal. Note the clearly increased MFC in the deep gray matter and the correspondent normal T2 images. MFC values are reported in s−2.

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    Fig 3.

    Representative MFC color maps and correspondent T2 images of 2 brain sections at the level of globus pallidus and thalamus in a 25-year-old male patient with mTBI. The patient complained of headache, neck stiffness, photophobia, and nausea; his GCS score was 13, and the conventional MR imaging scan was normal. Note the clearly increased MFC in the deep gray matter and the correspondent normal T2 images. MFC values are reported in s−2.

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    Fig 4.

    Representative MFC color maps and correspondent T2 images of 2 brain sections at the level of globus pallidus and thalamus in a 32-year-old male healthy volunteer. MFC values are reported in s−2.

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    Table 1:

    Clinical symptoms in the patient group

    SymptomNo. of Patients
    Blurry vision1
    Nausea9
    Memory loss8
    Dizziness7
    Photophobia6
    Neck stiffness5
    Loss of smell4
    Sleep disturbance3
    Headaches2
    Pain1
    Numbness1
    Tingling1
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    Table 2:

    Average MFC values (s−2) ± SDs in healthy controls and patients with mild traumatic brain injury

    Brain RegionControlsmTBI PatientsP
    Caudate269 ± 146326 ± 147.111
    Thalamus149 ± 59181 ± 65.036*
    Globus pallidus689 ± 252873 ± 327.002*
    Putamen430 ± 166493 ± 234.331
    Splenium243 ± 190210 ± 140.638
    Frontal lobe white matter273 ± 176203 ± 153.130
    • Note:—Asterisk indicates statistically significant comparisons.

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American Journal of Neuroradiology: 32 (10)
American Journal of Neuroradiology
Vol. 32, Issue 10
1 Nov 2011
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Cite this article
E. Raz, J.H. Jensen, Y. Ge, J.S. Babb, L. Miles, J. Reaume, R.I. Grossman, M. Inglese
Brain Iron Quantification in Mild Traumatic Brain Injury: A Magnetic Field Correlation Study
American Journal of Neuroradiology Nov 2011, 32 (10) 1851-1856; DOI: 10.3174/ajnr.A2637

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Brain Iron Quantification in Mild Traumatic Brain Injury: A Magnetic Field Correlation Study
E. Raz, J.H. Jensen, Y. Ge, J.S. Babb, L. Miles, J. Reaume, R.I. Grossman, M. Inglese
American Journal of Neuroradiology Nov 2011, 32 (10) 1851-1856; DOI: 10.3174/ajnr.A2637
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