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Research ArticleBrain

MR Imaging Texture Analysis of the Corpus Callosum and Thalamus in Amnestic Mild Cognitive Impairment and Mild Alzheimer Disease

M.S. de Oliveira, M.L.F. Balthazar, A. D'Abreu, C.L. Yasuda, B.P. Damasceno, F. Cendes and G. Castellano
American Journal of Neuroradiology January 2011, 32 (1) 60-66; DOI: https://doi.org/10.3174/ajnr.A2232
M.S. de Oliveira
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M.L.F. Balthazar
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A. D'Abreu
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C.L. Yasuda
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B.P. Damasceno
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F. Cendes
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G. Castellano
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    Fig 1.

    Boxplots for texture parameter-versus-subject groups for the CC (top row) and thalamus (bottom row), for the comparison among all the groups. X-axes show the studied groups, and y-axes show the magnitude of the texture parameter. The left column shows parameters that are differentiated well among groups, and the right column shows parameters that are not differentiated among groups. All plots correspond to distance d = 1.

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    Fig 2.

    Boxplots for texture parameter-versus-subject groups for the CC, for the pair-wise comparison between AD-control (top row) and AD-aMCI (bottom row). X-axes show the studied groups, and y-axes show the magnitude of the texture parameter. The left column shows parameters that are differentiated well among groups, and the right column shows parameters that are not differentiated among groups. All plots correspond to distance d = 1.

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    Fig 3.

    Maps of texture parameters computed by the MaZda software. Top row: MR imaging of a patient with AD (left), one with MCI (center), and a control subject (right). The middle and bottom rows show contrast and difference variance maps for these subjects respectively, computed from a GLCM with distance d = 1 pixel and direction θ = 90°. Both parameter maps show a variation in the CC gray level intensity for patients with AD and aMCI; it is brighter in the middle of this structure and darker at the sides. In patients with AD, the whole structure is brighter than that in patients with aMCI. This brightness variation does not occur for the control image. Although calculation of these maps used smaller regions than the segmented regions of interest used to compute the texture parameters shown in Tables 1⇑⇑–4 (see text), these maps give an idea of texture variation along the brain, showing that there are, indeed, texture differences among the AD, aMCI, and control individuals.

Tables

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    Table 1:

    Significant texture parameters obtained for the CC in the comparison among all groups (AD, aMCI and control)a

    DistanceTexture Parameter
    1Contrast, difference variance
    2Contrast, difference variance
    3Difference variance
    4Difference variance
    • a P value ≤ .05.

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    Table 2:

    Significant texture parameters obtained for the thalamus (left and right) in the comparison among all groups (AD, aMCI and control)a

    SideDistanceTexture Parameter
    Left1, 2, 3, 4Sum average
    Right1, 2, 3, 4Sum of squares
    Right2, 3, 4Contrast, difference variance
    Right3Sum variance
    Right2, 4Difference entropy
    • a P value ≤ .05.

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    Table 3:

    Significant texture parameters obtained for the CC in the pair-wise comparison (AD-control and aMCI-AD)a

    Group PairDistanceTexture Parameter
    AD-control1, 2, 3, 4Contrast
    AD-control1, 2, 3, 4Sum of squares
    AD-control1, 2, 3Difference variance
    AD-control3, 4Sum variance
    AD-control2Difference entropy
    aMCI-AD1, 2, 3, 4Difference variance
    • a P value ≤ .05.

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    Table 4:

    Significant texture parameters obtained for the thalamus in the pair-wise comparison (AD-control, aMCI-control, and aMCI-AD)a

    Group PairSideDistanceTexture Parameter
    AD-controlLeft3Contrast, difference variance
    AD-controlLeft4Contrast, sum of squares
    AD-controlRightAllSum of squares, difference variance
    AD-controlRight2, 3, 4Contrast, difference entropy
    AD-controlRight3, 4Sum variance
    AD-controlRight4Sum entropy
    aMCI-controlRight1Angular second moment
    aMCI-controlRight2, 4Contrast, difference entropy
    aMCI-controlRight2, 3, 4Sum of squares, difference variance
    aMCI-controlRight2Inverse difference moment
    aMCI-controlRight3, 4Sum variance
    aMCI-ADLeft1, 2, 3, 4Sum average
    • a P value ≤ .05.

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American Journal of Neuroradiology: 32 (1)
American Journal of Neuroradiology
Vol. 32, Issue 1
1 Jan 2011
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M.S. de Oliveira, M.L.F. Balthazar, A. D'Abreu, C.L. Yasuda, B.P. Damasceno, F. Cendes, G. Castellano
MR Imaging Texture Analysis of the Corpus Callosum and Thalamus in Amnestic Mild Cognitive Impairment and Mild Alzheimer Disease
American Journal of Neuroradiology Jan 2011, 32 (1) 60-66; DOI: 10.3174/ajnr.A2232

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MR Imaging Texture Analysis of the Corpus Callosum and Thalamus in Amnestic Mild Cognitive Impairment and Mild Alzheimer Disease
M.S. de Oliveira, M.L.F. Balthazar, A. D'Abreu, C.L. Yasuda, B.P. Damasceno, F. Cendes, G. Castellano
American Journal of Neuroradiology Jan 2011, 32 (1) 60-66; DOI: 10.3174/ajnr.A2232
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