MR Imaging Texture Analysis of the Corpus Callosum and Thalamus in Amnestic Mild Cognitive Impairment and Mild Alzheimer Disease

Maps of texture parameters computed by the MaZda software. Top row: MR imaging of a patient with AD (left), one with MCI (center), and a control subject (right). The middle and bottom rows show contrast and difference variance maps for these subjects respectively, computed from a GLCM with distance d = 1 pixel and direction θ = 90°. Both parameter maps show a variation in the CC gray level intensity for patients with AD and aMCI; it is brighter in the middle of this structure and darker at the sides. In patients with AD, the whole structure is brighter than that in patients with aMCI. This brightness variation does not occur for the control image. Although calculation of these maps used smaller regions than the segmented regions of interest used to compute the texture parameters shown in Tables 1⇑⇑–4 (see text), these maps give an idea of texture variation along the brain, showing that there are, indeed, texture differences among the AD, aMCI, and control individuals.