Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Case ReportBrain

Methadone-Induced Toxic Leukoencephalopathy: MR Imaging and MR Proton Spectroscopy Findings

R.A. Salgado, P.G. Jorens, I. Baar, P. Cras, G. Hans and P.M. Parizel
American Journal of Neuroradiology March 2010, 31 (3) 565-566; DOI: https://doi.org/10.3174/ajnr.A1889
R.A. Salgado
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P.G. Jorens
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
I. Baar
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P. Cras
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
G. Hans
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P.M. Parizel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Figures & Data

Figures

  • Fig 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 1.

    Axial FLAIR image with fat saturation (A) and a turbo spin-echo T2-weighted image (B). There are confluent and strikingly symmetric signal-intensity abnormalities in the white matter of both cerebral hemispheres, with sparing of the subcortical U-fibers. The posterior fossa structures are normal.

  • Fig 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 2.

    Proton single-voxel MR spectroscopy, performed with a TE value of 270 ms. There is a striking decrease of the NAA peak with a relative increase of the choline peak. A lactate peak with a resonance frequency at 1.32 ppm is present and shows a characteristic “up” doublet configuration.

PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 31 (3)
American Journal of Neuroradiology
Vol. 31, Issue 3
1 Mar 2010
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Methadone-Induced Toxic Leukoencephalopathy: MR Imaging and MR Proton Spectroscopy Findings
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
R.A. Salgado, P.G. Jorens, I. Baar, P. Cras, G. Hans, P.M. Parizel
Methadone-Induced Toxic Leukoencephalopathy: MR Imaging and MR Proton Spectroscopy Findings
American Journal of Neuroradiology Mar 2010, 31 (3) 565-566; DOI: 10.3174/ajnr.A1889

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Methadone-Induced Toxic Leukoencephalopathy: MR Imaging and MR Proton Spectroscopy Findings
R.A. Salgado, P.G. Jorens, I. Baar, P. Cras, G. Hans, P.M. Parizel
American Journal of Neuroradiology Mar 2010, 31 (3) 565-566; DOI: 10.3174/ajnr.A1889
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • Abbreviations
    • Case Report
    • Discussion
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Lesson of the month: Oxycodone-induced leukoencephalopathy: a rare diagnosis
  • Predicting the outcome of a comatose patient at the bedside
  • Delayed toxic-hypoxic encephalopathy
  • Crossref (45)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • The histopathology of drugs of abuse
    Christopher Mark Milroy, Jacqueline Louise Parai
    Histopathology 2011 59 4
  • Losses and gains: chronic pain and altered brain morphology
    David Borsook, Nathalie Erpelding, Lino Becerra
    Expert Review of Neurotherapeutics 2013 13 11
  • Chronic oxycodone induces axonal degeneration in rat brain
    Ruping Fan, Lisa M. Schrott, Thomas Arnold, Stephen Snelling, Meghana Rao, Derrel Graham, Angela Cornelius, Nadejda L. Korneeva
    BMC Neuroscience 2018 19 1
  • Methadone-induced Damage to White Matter Integrity in Methadone Maintenance Patients: A Longitudinal Self-control DTI Study
    Wei Li, Qiang Li, Yarong Wang, Jia Zhu, Jianjun Ye, Xuejiao Yan, Yongbin Li, Jiajie Chen, Jierong Liu, Zhe Li, Wei Wang, Yijun Liu
    Scientific Reports 2016 6 1
  • Neurocognitive impairments and brain abnormalities resulting from opioid-related overdoses: A systematic review
    Erin L. Winstanley, James J. Mahoney, Felipe Castillo, Sandra D. Comer
    Drug and Alcohol Dependence 2021 226
  • White matter lesions in chronic migraine with medication overuse headache: a cross-sectional MRI study
    Zhenyang Zheng, Zijian Xiao, Xiaolei Shi, Minghui Ding, Wei Di, Weiwei Qi, Aiwu Zhang, Yannan Fang
    Journal of Neurology 2014 261 4
  • Methadone-Induced Toxic Leukoencephalopathy: Diagnosis and Follow-up by Magnetic Resonance Imaging Including Diffusion-Weighted Imaging and Apparent Diffusion Coefficient Maps
    Alfonso Cerase, Sara Leonini, Matteo Bellini, Giuseppe Chianese, Carlo Venturi
    Journal of Neuroimaging 2011 21 3
  • Cation-selective exhaustive injection and sweeping micellar electrokinetic chromatography for the analysis of methadone and its metabolites in serum of heroin addicts
    Chun-Chi Wang, Cheng-Chung Chen, Shang-Jang Wang, Shou-Mei Wu
    Journal of Chromatography A 2011 1218 38
  • Acute brain injury following illicit drug abuse in adolescent and young adult patients: spectrum of neuroimaging findings
    Shai Shrot, Andrea Poretti, Elizabeth W Tucker, Bruno P Soares, Thierry AGM Huisman
    The Neuroradiology Journal 2017 30 2
  • Methadone use in a male with the FMRI premutation and FXTAS
    Zukhrofi Muzar, Reymundo Lozano, Andrea Schneider, Patrick E. Adams, Sultana M.H. Faradz, Flora Tassone, Randi J. Hagerman
    American Journal of Medical Genetics Part A 2015 167 6

More in this TOC Section

  • Usefulness of Quantitative Susceptibility Mapping for the Diagnosis of Parkinson Disease
  • White Matter Alterations in the Brains of Patients with Active, Remitted, and Cured Cushing Syndrome: A DTI Study
  • Qualitative and Quantitative Analysis of MR Imaging Findings in Patients with Middle Cerebral Artery Stroke Implanted with Mesenchymal Stem Cells
Show more BRAIN

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire