High-b-Value Diffusion MR Imaging and Basal Nuclei Apparent Diffusion Coefficient Measurements in Variant and Sporadic Creutzfeldt-Jakob Disease

H. Hyare; J. Thornton; J. Stevens; S. Mead; P. Rudge; J. Collinge; T.A. Yousry; H.R. Jäger

doi:10.3174/ajnr.A1860

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Fig 1.
The position of the key ROIs on (A) b = 0, (B) b = 1000, and (C) b = 3000 ADC map.
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Fig 2.
Differences in SIs in the basal ganglia in sCJD at (A) b = 1000 and (B) b = 3000 and in vCJD at (C) b = 1000 and (D) b = 3000.
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Fig 3.
Bar charts showing ROI ADC values in sCJD (hashed bars) and controls (solid bars) at (A) b = 1000 s/mm² and (B) b = 3000 s/mm².

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Table 1:

Visual assessment of SI findings in vCJD and sCJD on FLAIR and DWI (b = 1000 s/mm²)

	C	P	DM	Cortex	SP	FWM
vCJD
1	+	+	+	−	−	−
2	+	+	+	−	−	−
3	−	−	+	−	−	−
4	+	−	+	−	−	−
5	−	−	+	−	−	−
6	+	+	+	−	−	−
7	+	−	+	−	−	−
8	+	+	+	−	−	−
sCJD
1	+	+	+	+	−	−
2	+	+	−	+	−	−
3	+	+	+	+	−	−
4	+	+	+	+	−	−
5	+	+	+	+	−	−
6	+	+	−	+	−	−
7	+	−	−	+	−	−
8	+	+	+	+	−	−
9	+	+	+	+	−	−

Note:—+ signifies hyperintense to gray matter; −, isointense to gray matter.

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Table 2:

Summary of mean diffusivity values (in mm²/s) measured in vCJD patients, sCJD patients, and controls for each ROI at b = 1000 s/mm² with P values from post hoc comparisons

Group	SP	C	P	DM	Pu	FWM
(A) vCJD	741.6 (104.0)	687.9 (70.6)	670.9 (56.2)	834.1 (51.3)	837.6 (33.0)	820.7 (44.6)
(B) sCJD	753.8 (44.3)	587.3 (84.6)	603.3 (98.7)	691.8 (85.7)	—	830.9 (89.1)
(C) Control	754.8 (64.9)	722.7 (16.6)	727.8 (24.4)	763.7 (17.1)	748.0 (17.4)	773.7 (43.7)
A versus C	P = .949	P = .655	P = .382	P = .159	P < .001	P = .450
A versus B	P = .941	P = .021	P = .167	P = .001	—	P = .947
B versus C	P = 1.000	P = .007	P = .018	P = .137	—	P = .299

Note:—b = 1000 s/mm² (group averages for 8 vCJD and 9 sCJD patients). All data are expressed as mean values with SD in parentheses. Significant P values are in bold.

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Table 3:

Summary of mean diffusivity values (in mm²/s) measured in vCJD patients, sCJD patients, and controls for each ROI at b = 3000 s/mm² with P values from post hoc comparisons

Group	SP	C	P	DM	Pu	FWM
(A) vCJD	524.5 (87.7)	554.8 (69.4)	530.3 (49.7)	584.7 (48.1)	603.2 (59.0)	556.6 (23.7)
(B) sCJD	493.9 (87.9)	478.4 (27.5)	477.1 (77.8)	485.8 (87.4)	—	539.5 (39.9)
(C) Control	484.1 (19.9)	628.3 (15.4)	594.8 (8.8)	627.3 (13.1)	625.4 (10.6)	528.3 (41.4)
A versus C	P = .652	P = .063	P = .156	P = .460	P = .432	P = .444
A versus B	P = .800	P = .068	P = .302	P = .050	—	P = .759
B versus C	P = .977	P = .001	P = .014	P = .007	—	P = .885

Note:—b = 3000 s/mm² (group averages for 4 vCJD and 5 sCJD patients). All data are expressed as mean values with SD in parentheses. Significant P values are in bold.