PT  - JOURNAL ARTICLE
AU  - Hyare, H.
AU  - Thornton, J.
AU  - Stevens, J.
AU  - Mead, S.
AU  - Rudge, P.
AU  - Collinge, J.
AU  - Yousry, T.A.
AU  - Jäger, H.R.
TI  - High-b-Value Diffusion MR Imaging and Basal Nuclei Apparent Diffusion Coefficient Measurements in Variant and Sporadic Creutzfeldt-Jakob Disease
AID  - 10.3174/ajnr.A1860
DP  - 2010 Mar 01
TA  - American Journal of Neuroradiology
PG  - 521--526
VI  - 31
IP  - 3
4099  - http://www.ajnr.org/content/31/3/521.short
4100  - http://www.ajnr.org/content/31/3/521.full
SO  - Am. J. Neuroradiol.2010 Mar 01; 31
AB  - BACKGROUND AND PURPOSE: DWI using a standard b-value of 1000s/mm2 has emerged as the most sensitive sequence for the diagnosis of CJD. The purpose of this study was to investigate whether DWI at a high b-value (b = 3000 s/mm2) and ADC measurements in the basal nuclei improve the diagnosis of vCJD and sCJD compared with visual assessment of DWI at a standard b-value (b = 1000 s/mm2). MATERIALS AND METHODS: Eight patients with vCJD, 9 patients with sCJD, and 5 healthy volunteers underwent DWI at b = 1000 s/mm2, and 5 vCJD patients, 4 sCJD patients, and 1 growth hormone-related CJD patient underwent DWI at b = 3000 s/mm2. Two consultant neuroradiologists performed a visual comparison of the b = 1000 and b = 3000 images. Mean MR SI and ADC values were determined for C, P, and DM thalamus ROIs bilaterally at each b-value. SI ratios for each ROI relative to white matter were calculated. RESULTS: In 9 out of 10 patients, the higher b-value images were more sensitive to SI change, particularly in cortex and thalamus, with higher SI ratios at b = 3000 in the DM thalamus. For sCJD at b = 1000, we found significantly lower ADC values in the C and P compared with controls (mean C ADC = 587.3 ± 84.7 mm2/s in sCJD patients versus 722.7 ± 16.6 mm2/s in controls; P = .007), and at b = 3000, the differences were more pronounced. In comparison, in vCJD at b = 1000, ADC values were elevated in the Pu (mean Pu ADC = 837.6 ± 33.0 mm/s2 in vCJD patients versus 748.0 ± 17.3 mm/s2 in controls; P < .001) but failed to reach significance at b = 3000. CONCLUSIONS: Our results demonstrate that b = 3000 DWI, being more sensitive to slowly diffusing tissue water, is more sensitive to pathology in sCJD than is conventional DWI. High-b-value DWI increases confidence in the radiologic diagnosis of human prion disease. ADCapparent diffusion coefficientCcaudateDMdorsomedialDWIdiffusion-weighted imagingFLAIRfluid-attenuated inversion recoveryFWMfrontal white matterPputamenPupulvinarROIregion of interestsCJDsporadic Creutzfeldt-Jakob DiseaseSIsignal intensitySPsuperior ponsvCJDvariant Creutzfeldt-Jakob Disease