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Improved Turnaround Times | Median time to first decision: 12 days

Research ArticleBrain
Open Access

Tracer Delay–Insensitive Algorithm Can Improve Reliability of CT Perfusion Imaging for Cerebrovascular Steno-Occlusive Disease: Comparison with Quantitative Single-Photon Emission CT

M. Sasaki, K. Kudo, K. Ogasawara and S. Fujiwara
American Journal of Neuroradiology January 2009, 30 (1) 188-193; DOI: https://doi.org/10.3174/ajnr.A1274
M. Sasaki
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K. Kudo
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K. Ogasawara
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S. Fujiwara
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    Fig 1.

    CBF and MTT maps of a 70-year-old woman with occlusion of the right MCA. A and E, CTP with bSVD. B and F, CTP with sSVD. C and G, CTP with bMTF. D, Quantitative SPECT with 123I-IMP. A–D, CBF. E–G, MTT. AIF was obtained from the second portion of the left MCA. A–C, E–G, CBF and MTT color maps on CTP appear different among the different deconvolution algorithms. B–D, Images obtained by using sSVD (B) and bMTF (C) overestimate the decrease in CBF of the right MCA territory, compared with that generated by SPECT (D), whereas images using bSVD (A) correspond well with those using SPECT (D).

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    Fig 2.

    Absolute CBF values of the unaffected and affected MCA territories with different algorithms and different locations of AIFs. The ranges of the CBF obtained by bSVD in any conditions and those obtained by sSVD with the AIF on the unaffected MCA are significantly smaller than the corresponding ranges obtained by quantitative SPECT. However, those obtained by bMTF are significantly larger than those obtained by SPECT, particularly when the AIF is on the affected MCA. The CBF ranges obtained by sSVD with the AIF on the affected MCA are compatible with those generated by SPECT. †P < .01.

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    Fig 3.

    The CBF ratios of the affected MCA territory to the contralateral corresponding area with different algorithms and different locations of AIFs. When comparing the CBF ratios with SPECT, we observed that the CBF ratios were underestimated in many patients on CTP with sSVD and bMTF but not with bSVD, regardless of the location (affected or unaffected side) of the AIF on the MCA.

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  • Correlation of the CBF values between CTP and SPECT

    CBFAIF Unaffected SideAIF Affected Side
    Unaffected SideAffected SideRatioUnaffected SideAffected SideRatio
    bSVD
        r20.58*0.46†0.70‡0.440.360.60*
        ICC−0.31−0.420.64‡−0.22−0.300.58*
    sSVD
        r20.52†0.220.50†0.46†0.080.40
        ICC0.25−0.360.020.43†0.020.03
    bMTF
        r20.400.250.57*0.220.220.11
        ICC0.210.26−0.04−0.31−0.30−0.23
    • Note:—CBF indicates cerebral blood flow; CTP, CT perfusion; SPECT, single-photon emission CT; AIF, arterial input function; bSVD, block-circulant singular value decomposition; SSVD, standard SVD; bMTF, box-modulation transfer function: ICC, intraclass correlation coefficient.

    • * P < .01.

    • † P < .05.

    • ‡ P < .001.

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American Journal of Neuroradiology: 30 (1)
American Journal of Neuroradiology
Vol. 30, Issue 1
January 2009
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Tracer Delay–Insensitive Algorithm Can Improve Reliability of CT Perfusion Imaging for Cerebrovascular Steno-Occlusive Disease: Comparison with Quantitative Single-Photon Emission CT
M. Sasaki, K. Kudo, K. Ogasawara, S. Fujiwara
American Journal of Neuroradiology Jan 2009, 30 (1) 188-193; DOI: 10.3174/ajnr.A1274
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M. Sasaki, K. Kudo, K. Ogasawara, S. Fujiwara
Tracer Delay–Insensitive Algorithm Can Improve Reliability of CT Perfusion Imaging for Cerebrovascular Steno-Occlusive Disease: Comparison with Quantitative Single-Photon Emission CT
American Journal of Neuroradiology Jan 2009, 30 (1) 188-193; DOI: 10.3174/ajnr.A1274

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