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Improved Turnaround Times | Median time to first decision: 12 days

Research ArticleHead and Neck Imaging

Prediction of Treatment Response in Head and Neck Cancer by Magnetic Resonance Spectroscopy

Tedros Bezabeh, Olva Odlum, Richard Nason, Paul Kerr, Donna Sutherland, Rakesh Patel and Ian C.P. Smith
American Journal of Neuroradiology September 2005, 26 (8) 2108-2113;
Tedros Bezabeh
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Olva Odlum
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Richard Nason
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Paul Kerr
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Donna Sutherland
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Rakesh Patel
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Ian C.P. Smith
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Article Figures & Data

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  • Fig 1.
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    Fig 1.

    360 MHz 1H MR spectra of head and neck tumors (A) control (B) failed case. Both specimens came from oral tongue tumors. Chos, choline-containing compounds; Cr, creatines; Gln, glutamine; Glu, glutamic acid; HOD, deuteriated water; Lac, lactic acid; Leu, leucine; Lip, lipid; Tau, taurine; Val, valine. Assignments do not imply that these are the only substances contributing to a particular peak.

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    Fig 2.

    Bar graphs of the 3.2/3.0 spectral intensity ratio (mean ± SEM). Dark shade, control; light shade, failed cases; A, tumors from all sites included; B, tumors of the tongue only.

  • Fig 3.
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    Fig 3.

    Bar graphs of the 1.3/0.9 spectral intensity ratio (mean ± SEM). Dark shade, control; light shade, failed cases; A, tumors from all sites included; B, tumors of the larynx only.

Tables

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    TABLE 1:

    Prediction of response by MRS in head and neck cancer

    SiteNo. of Cases
    FailedControl
    Larynx513
    Tongue153
    Floor91
    Tonsil21
    Alveolus—2
    Esophagus11
    Pharynx2—
    Retromolar trigone20
    Nose—1
    Total3622
    • Note.—MRS indicates magnetic resonance spectroscopy.

    • View popup
    TABLE 2:

    Prediction of response by MRS in head and neck cancer

    SiteCasesStage (TNM)Treatment
    LarynxFailedT2N0Surgery
    ControlT3N0Surgery
    LarynxFailedT4N0Surgery
    ControlT2N0Radiation
    LarynxFailedT2N0Laser surgery
    ControlT3N0Surgery
    LarynxFailedT4N0Radiation
    ControlT4N1Surgery + radiation
    LarynxFailedT3N0Surgery + radiation
    ControlT2N0Surgery + radiation
    Oral tongueFailedT2N2bSurgery + radiation
    ControlT1N0Surgery
    Oral tongueFailedT1N0Surgery
    ControlT2N0Surgery + radiation
    Oral tongueFailedT3N2Surgery
    ControlT4N2bSurgery
    Floor of mouthFailedT4N2bSurgery + chemotherapy + radiation
    ControlT4N0Surgery + radiation
    TonsilFailedT2N1Radiation
    ControlT2N2Radiation
    • Note.—MRS indicates magnetic resonance spectroscopy.

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American Journal of Neuroradiology: 26 (8)
American Journal of Neuroradiology
Vol. 26, Issue 8
1 Sep 2005
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Prediction of Treatment Response in Head and Neck Cancer by Magnetic Resonance Spectroscopy
Tedros Bezabeh, Olva Odlum, Richard Nason, Paul Kerr, Donna Sutherland, Rakesh Patel, Ian C.P. Smith
American Journal of Neuroradiology Sep 2005, 26 (8) 2108-2113;
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Cite this article
Tedros Bezabeh, Olva Odlum, Richard Nason, Paul Kerr, Donna Sutherland, Rakesh Patel, Ian C.P. Smith
Prediction of Treatment Response in Head and Neck Cancer by Magnetic Resonance Spectroscopy
American Journal of Neuroradiology Sep 2005, 26 (8) 2108-2113;

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