Article Figures & Data
Figures
- Fig 1.
Illustration of lesion definitions on a representative ADC image at day 0. Lesion on day 0 in black = ADC lesion at day 0; dark gray = lesion growth until day 1 (LG1); pale gray = lesion growth until day 7 (LG7); white = surviving tissue (ST7). LG1 and LG7 were found by surrounding follow-up T2 lesions at day 1 and 7 and transfer onto day 0 PWI images. ST7 is tissue initially showing CBF decrease but without T2 changes at day 7.
- Fig 2.
Relative contribution of the three most frequent occlusion types to the total lesion volumes at day 0 (L0) or lesion growth LG1 and LG7. 100% is the sum of the lesions volumes of the three occlusion types.
Tables
Occlusion n rt-PA Recanalization Day 7 L0 LG1 LG7 ST7 ICA/MCA 1 1 0 18.2 28.7 33.5 197.5 Carotid T 5 5 3 16.3 36.8 34.8 150.9 0.6–80.3 11.7–128.4 10.1–71.6 68.3–177.0 M1/2 7 4 5 18.0 17.9 4.4 166.3 7.0–78.8 1.7–44.1 0.2–16.2 94.8–180.6 MCA-branch 6 3 5 30.1 9.7 1.0 41.7 0.1–70.9 0.3–30.2 0.6–2.6 11.1–97.0 Note.—ICA/MCA indicates occlusion of the internal carotid artery with accompanying occlusion of the middle cerebral artery; CTO, occlusion of the intracranial ICA bifurcation (carotid T occlusion), MCA occlusion of the trunk or trifurcation (M1/2), and MCA branch occlusion (segments M3 and M4); rt-PA, recombinant tissue plasminogen activator; L0, lesion at day 0 defined by a reduced apparent diffusion coefficient (ADC); LG1 and LG7, lesion growth on T2-weighted images until day 1 and 7; and ST7 = surviving tissue at day 7 (tissue with initially reduced cerebral blood flow but without T2 prolongation at day 7). Volumes are median and range (min–max).
L0 LG1 LG7 ST7 rCBF 0.32 ± 0.13 0.45 ± 0.11 0.59 ± 0.25 0.62 ± 0.10 rCBV 0.57 ± 0.18 0.71 ± 0.13 0.89 ± 0.21 1.02* ± 0.12 rMTT 1.83 ± 0.48 1.74 ± 0.39 1.57 ± 0.36 1.51 ± 0.28 rTTP 1.44 ± 0.25 1.28 ± 0.17 1.17 ± 0.14 1.13 ± 0.08 MTT [s] 8.1 ± 4.8 7.4 ± 3.6 5.8 ± 3.5 5.1 ± 2.6 TTP [s] 9.1 ± 4.1 5.8 ± 3.0 3.6 ± 2.9 2.7 ± 1.6 Note.—Mean perfusion values determined on MRI at day 0 by definition of L0, LG1, LG7 and ST7. L0 is the region with decreased ADC at day 0. LG1 and LG7 were defined by surrounding the T2 lesion on follow-up imaging at day 1 and 7, respectively. ST7 is surviving tissue with reduced cerebral blood flow at day 0 but without T2 prolongation at day 7. Transfer of LG1, LG7 and ST7 onto the initial day 0 PWI images revealed the perfusion values in these ROIs at day 0. rCBF indicates relative cerebral blood flow (relation of affected/unaffected contralateral control region); rCBV, relative cerebral blood volume; rMTT, relative mean transit time; and rTTP, relative time to peak. MTT and TTP are absolute values of bolus passage delay. P = .02.
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