Article Figures & Data
Figures
- Fig 1.
Example of a tissue sample and the matching area on postmortem MR images. WM lesions (WM), as well as type I lesions (I, mixed GM-WM), can be seen with relative ease on the different MR images. Intracortical lesions (IC) are difficult to detect and define, even in retrospect.
A, Photomicrograph (MBP immunohistochemical stain) reveals lesions (arrowheads) in the WM and cortical GM.
B, Short-echo T2-weighted SE image. Insert, a higher magnification of the intracortical lesion.
C, Long-echo T2-weighted SE image.
D, 3D FLAIR image.
- Fig 2.
Lesion scores. I, type I cortical lesions; DGML indicates deep GM lesions; WML, WM lesions; total, total of all lesion categories; PA, lesions detected histopathologically; T2, lesions detected on postmortem T2SE imaging; and FLAIR, lesions detected on postmortem 3D FLAIR imaging.
A, Blinded.
B, After unblinding, numbers of detected lesions in all categories increased (retrospective scoring). However, a significant proportion of intracortical lesions remained undetectable.
Tables
Patient/Sex/Age (y) Postmortem Delay (h:min) Disease Duration (y) Type Cause of death 1/M/43 08:30 17 Secondary progressive Pneumonia 2/F/48 04:50 25 Secondary progressive Euthanasia 3/F/72 10:30 13 Unknown Pneumonia 4/M/77 04:15 32 Primary progressive Cerebral infarct 5/F/75 08:00 42 Secondary progressive Pneumonia 6/F/53 10:45 23 Secondary progressive Euthanasia 7/M/81 08:50 51 Primary progressive General deterioration 8/F/59 08:45 24 Secondary progressive Respiratory insufficiency 9/F/48 05:50 21 Unknown Congestive heart failure Note.—Mean age was 62 years, mean postmortem delay was 7:50, and mean disease duration was 28 y.
Type Lesions on Histopathology Prospective* Retrospective† T2SE FLAIR T2SE FLAIR I 27 6 (22) 11 (41) 20 (74) 27 (100) II 12 0 (0) 1 (8) 6 (50) 9 (75) III 41 1 (2) 2 (5) 22 (54) 26 (63) IV 10 1 (10) 0 (0) 7 (70) 10 (100) II-IV 63 2 (3) 3 (5) 35 (56) 45 (71) Deep GM 8 1 (13) 3 (38) 5 (63) 7 (88) WM 70 44 (63) 50 (71) 65 (93) 68 (97) Total 168 53 (32) 67 (40) 125 (74) 147 (88) Note.—Data in parentheses are the sensitivity (%).
* Lesions found without knowledge of histopathologic localization and type.
† Lesions found after the histopathologic localization of lesions was revealed.
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