Article Figures & Data
Figures
- Fig 1.
Images from the case of a 65-year-old man with an unruptured aneurysm (case 1).
A, Pretreatment cerebral angiogram shows the 5-mm anterior communicating artery aneurysm.
B, Post-treatment cerebral angiogram shows embolization by interlocking detachable coils (4 mm × 8 cm and 3 mm × 6 cm).
- Fig 2.
Gross pathologic findings in case 1.
A, Gross outlook appearance of the thin wall of the aneurysm through which embedded coils are seen.
B, Intraluminal view shows a thin transparent layer of membrane covering the whole orifice of the aneurysm and bridged over the underlying coils.
C, Scanning electron microscopy shows that the coils are covered by thick neointima at the orifice of the aneurysm. Part of the neointima was removed for transmission electron microscopic study (original magnification, ×50; bar = 100 μm).
D, Superficial layer of neointima with a cobblestone appearance (original magnification, ×1000; bar = 10 μm).
- Fig 3.
Transmission electron microscopy and light microscopy (case 1).
A, Basal lamina runs contiguously along the basal endothelial cytoplasmic membrane (original magnification, ×2000; bar = 2 μm).
B, Light microscopy shows cotton-like white fibrous tissue in the dome of the aneurysm (hematoxylin and eosin stain; original magnification, ×74).
- Fig 4.
Images from the case of a 62-year-old man with subarachnoid hemorrhage (case 2).
A, Right pre-embolization vertebral angiography shows 4-mm left basilar artery-superior cerebellar artery aneurysm.
B, After embolization by GDC (3 mm × 4 cm and 2 mm × 4 cm), almost total obliteration was achieved.
C, Gross examination shows thin membrane on coils at orifice of aneurysm. The thin fragile covering bridges the whole space across the coils at the orifice.
D, Scanning electron microscopy shows neointima partially covering the coils (GDC-10 soft). A cobblestone pattern can be seen (original magnification, ×370; bar = 100 μm).
