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Research ArticlePediatric Neuroimaging

Developmental Delay in Children: Assessment with Proton MR Spectroscopy

Christopher G. Filippi, Aziz M. Uluğ, Michael D. F. Deck, Robert D. Zimmerman and Linda A. Heier
American Journal of Neuroradiology May 2002, 23 (5) 882-888;
Christopher G. Filippi
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Aziz M. Uluğ
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Michael D. F. Deck
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Robert D. Zimmerman
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Linda A. Heier
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References

  1. ↵
    Cunningham RD Jr. Neuroimaging studies in children with developmental delay [comment]. J Pediatr 1996;128:302
  2. Filipek PA. Neuroimaging in the developmental disorders: the state of the science. J Child Psychol Psychiatry 1999;40:113–128
    CrossRefPubMedWeb of Science
  3. Bouhadiba Z, Dacher J, Monroe M, Vanhulle C, Menard J, Kalifa G. MRI of the brain in the evaluation of children with developmental delay. J Radiol 2000;81:870–873
    PubMedWeb of Science
  4. ↵
    Aicardi J. The etiology of developmental delay. Semin Pediatr Neurol 1998;5:15–20
    CrossRefPubMed
  5. ↵
    Schaefer GB, Bodensteiner JB. Radiological findings in developmental delay. Semin Pediatr Neurol 1998;5:33–38
    CrossRefPubMed
  6. Battaglia A, Bianchini E, Carey JC. Diagnostic yield of the comprehensive assessment of developmental delay/mental retardation in an institute of child neuropsychiatry. Am J Med Genet 1999;82:60–66
    CrossRefPubMedWeb of Science
  7. ↵
    Shevell MI. The evaluation of the child with a global developmental delay. Semin Pediatr Neurol 1998;5:21–26
    CrossRefPubMed
  8. ↵
    Hashimoto T, Tayama M, Miyazaki M, et al. Differences in brain metabolites between patients with autism and mental retardation as detected by in vivo localized proton magnetic resonance spectroscopy. J Child Neurol 1997;12:91–96
    Abstract/FREE Full Text
  9. Castillo M, Kwock L, Courvoisie H, Hooper SR. Proton MR spectroscopy in children with bipolar affective disorder: preliminary observations. Am J Neurol 1999;21:832–838
  10. ↵
    Moore GJ. Proton magnetic resonance spectroscopy in pediatric neuroradiology. Pediatr Radiol 1998;28:805–814
    CrossRefPubMedWeb of Science
  11. ↵
    Zimmerman RA, Wang ZJ. The value of proton MR spectroscopy in pediatric metabolic brain disease. AJNR Am J Neuroradiol 1997;18:1872–1879
    PubMedWeb of Science
  12. ↵
    Wang Z, Zimmerman RA, Sauter R. Proton MR Spectroscopy of the Brain: Clinically Useful Information Obtained in Assessing CNS Diseases in Children. AJR Am J Roentgenol 1996;167:191–199
    PubMedWeb of Science
  13. Shevell MI, Ashwal S, Novotny E. Proton magnetic resonance spectroscopy: clinical applications in children with nervous system diseases. Semin Pediatr Neurol 1999;6:68–77
    CrossRefPubMed
  14. ↵
    Tzika AA, Vigneron DB, Ball WS Jr, Dunn RS, Kirks DR. Localized proton MR spectroscopy of the brain in children. J Magn Reson Imaging 1993;5:719–729
  15. ↵
    Novotny E, Ashwal S, Shevell M. Proton magnetic resonance spectroscopy: an emerging technology in pediatric neurology research. Pediatr Res 1998;44:1–10
    PubMedWeb of Science
  16. ↵
    Barkovich AJ, Baranski K, Vigneron J, et al. Proton MR spectroscopy for the evaluation of brain injury in asphyxiated, term neonates. AJNR Am J Neuroradiol 1999;20:1399–1405
    Abstract/FREE Full Text
  17. Hanrahan JD, Cox IJ, Azzopardi D, et al. Relation between proton magnetic resonance spectroscopy within 18 hours of birth asphyxia and neurodevelopment at 1 year of age. Dev Med Child Neurol 1999;41:76–82
    CrossRefPubMedWeb of Science
  18. Holshouser BA, Ashwal S, Luh GY, et al. Proton MR spectroscopy after acute central nervous system injury: outcome prediction in neonates, infants, and children. Radiology 1997;202:487–496
    PubMedWeb of Science
  19. Shu SK, Ashwal S, Holshouser BA, Nystrom G, Hinshaw DB Jr. Prognostic value of 1H-MRS in perinatal CNS insults. Pediatr Neurol 1997;17:309–318
    CrossRefPubMedWeb of Science
  20. Leth H, Toft PB, Peitersen B, Lou HC, Henriksen O. Use of brain lactate levels to predict outcome after perinatal asphyxia. Acta Pediatr 1996;85:859–864
    PubMedWeb of Science
  21. Penrice J, Cady EB, Lorek A, et al. Proton magnetic resonance spectroscopy of the brain in normal preterm and term infants, and early changes after perinatal hypoxia-ischemia. Pediatr Res 1996;40:6–14
    PubMedWeb of Science
  22. ↵
    Cady EB, Amess P, Penrice J, Wylezinska M, Sams V, Wyatt JS. Early cerebral-metabolite quantification in perinatal hypoxic-ischemic encephalopathy by proton and phosphorous magnetic resonance spectroscopy. Magn Reson Imaging 1997;15:605–611
    CrossRefPubMedWeb of Science
  23. ↵
    Dietrich RB, Bradley WG, Zaragoza EJ, et al. MR evaluation of early myelination patterns in normal and developmentally delayed infants. AJR Am J Roentgenol 1988;150:889–896
    CrossRefPubMedWeb of Science
  24. ↵
    Harbord MG, Finn JP, Hall-Craggs MA, Robb SA, Kendall BE, Boyd SG. Myelination patterns on magnetic resonance of children with developmental delay. Dev Med Child Neurol 1990;32:295–303
    PubMedWeb of Science
  25. ↵
    Hashimoto T, Tayama M, Miyazaki M, et al. Developmental brain changes investigated with proton magnetic resonance spectroscopy. Dev Med Child Neurol 1995;37:398–405
    PubMedWeb of Science
  26. Brody BA, Kinney HC, Kloman AS, Gilles FH. Sequence of central nervous system myelination in human infancy: an autopsy study of myelination. J Neuropath 1987;46:283–301
  27. ↵
    Barkovich AJ, Kjos BO, Jackson DE Jr, Norman D. Normal maturation of the neonatal and infant brain: MR imaging at 1.5 T. Radiology 1988;166:173–180
    PubMedWeb of Science
  28. ↵
    Cady EB, Penrice J, Amess PN, et al. Lactate, N-acetylaspartate, choline, and creatine concentrations and spin-spin relaxation in thalamic and occipito-parietal regions of developing human brain. Magn Reson Med 1996;36:878–886
    PubMed
  29. ↵
    Kreis R, Ernst T, Ross BD. Development of the human brain: in vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy. Magn Reson Med 1993;30:424–437
    CrossRefPubMedWeb of Science
  30. ↵
    Kimura H, Fujii Y, Itoh S, et al. Metabolic alterations in the neonate and infant brain during development: evaluation with proton MR spectroscopy. Radiology 1995;194:483–489
    PubMedWeb of Science
  31. ↵
    Kadota T, Horinouchi T, Kuroda C. Development and aging of the cerebrum: assessment with proton MR spectroscopy. AJNR Am J Neuroradiol 2001;22:128–135
    Abstract/FREE Full Text
  32. ↵
    Toft PB, Leth H, Lou HC, Pryds O, Henriksen O. Metabolite concentrations in the developing brain estimated with proton MR spectroscopy. J Magn Reson Imaging 1994;4:674–680
    PubMedWeb of Science
  33. ↵
    Peden CJ, Cowan FM, Bryant DJ, et al. Proton MR spectroscopy of the brain in infants. J Comput Assist Tomogr 1990;14:886–894
    PubMedWeb of Science
  34. ↵
    Yeo RA, Hill D, Campbell R, Vigil J, Brooks WM. Developmental instability and working memory ability in children: a magnetic resonance spectroscopy investigation. Dev Neuropsych 2000;17:143–159.
  35. ↵
    Friedman SF, Brooks WM, Jung RE, et al. Quantitative 1H-MRS predicts outcome following traumatic brain injury. Neurology 1999;52:1384–1396
    Abstract/FREE Full Text
  36. ↵
    Ford CC, Griffey RH, Matwiyoff NA, Rosenberg GA. Multivoxel MRS of stroke. Neurology 1992;42:653–659
  37. ↵
    Lentner C. Geigy Scientific Tables. Vol 1. Basel: Ciba-Geigy;1981
  38. ↵
    Lentner C. Geigy Scientific Tables. Vol 3. Basel: Ciba-Geigy;1984
  39. ↵
    Scarabino T, Popolizio T, Bertolino A, Salvolini U. Proton magnetic resonance spectroscopy of the brain in pediatric patients. Eur J Radiol 1999;30:142–153
    CrossRefPubMed
  40. ↵
    Kruse B, Barker PB, van Zijl PCM, Duyn JH, Moonen CTW, Moser HW. Multislice proton magnetic-resonance spectroscopic imaging in X-linked adrenoleukodystrophy. Ann Neurol 1994;36:595–608
    CrossRefPubMedWeb of Science
  41. ↵
    Squires LA, Krishnamoorthy KS, Natowicz MR. Delayed myelination in infants and young children: radiographic and clinical correlates. J Child Neurol 1995;10:100–104
    Abstract/FREE Full Text
  42. ↵
    Michaelis T, Merboldt KD, Bruhn H, Hanicke W, Frahm J. Absolute concentrations of metabolites in the adult human brain in vivo: quantification of localized proton MR spectra. Radiology 1993;187:219–227
    PubMedWeb of Science
  43. ↵
    Provencher SW. Estimation of metabolitec concentrations from localized in vivo proton NMR spectra. Magn Reson Med 1993;30:672–679
    CrossRefPubMedWeb of Science
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American Journal of Neuroradiology: 23 (5)
American Journal of Neuroradiology
Vol. 23, Issue 5
1 May 2002
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Christopher G. Filippi, Aziz M. Uluğ, Michael D. F. Deck, Robert D. Zimmerman, Linda A. Heier
Developmental Delay in Children: Assessment with Proton MR Spectroscopy
American Journal of Neuroradiology May 2002, 23 (5) 882-888;

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Developmental Delay in Children: Assessment with Proton MR Spectroscopy
Christopher G. Filippi, Aziz M. Uluğ, Michael D. F. Deck, Robert D. Zimmerman, Linda A. Heier
American Journal of Neuroradiology May 2002, 23 (5) 882-888;
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