Article Figures & Data
Figures
- Fig 1.
PRESS image (2000/144/8) demonstrates voxel placement in the frontal subcortical white matter (box). Voxels were used to assess NAA/Cr ratios and Cho/Cr ratios.
- Fig 2.
Comparison of patient and control spectra in the group aged 2 years or younger.
A, Proton MR spectrum in left frontal white matter in a 1.5-year-old control subject demonstrates an NAA/Cr ratio of 2.12 and a Cho/Cr ratio of 1.81.
B, Proton MR spectrum from a voxel placed in the subcortical white matter of the left frontal lobe in a 1.5-year-old patient with mild developmental delay demonstrates a slightly higher Cho peak and higher Cho/Cr ratio of 2.01. This value, however, was not significantly different than that in the 1.5-year-old control subject. Likewise, the NAA peak is slightly lower and the NAA/Cr ratio of 1.94 is less than that in the control subject but not significantly different.
- Fig 3.
Comparison of patient and control spectra in the frontal lobe subcortical white matter in the group aged older than 2 years.
A, Proton MR spectrum in a 5-year-old patient with mild developmental delay in language and coordination demonstrates marked increase in the Cho/Cr ratio to 1.79. There is a decrease in the NAA/Cr ratio to 2.06, which resembles the MR spectrum of a much younger child such as seen in the 1.5-year-old children in Fig 2.
B, Proton MR spectrum in a 5-year-old control patient demonstrates a pattern resembling that of an adult, with an NAA peak that is 2 times higher than the Cr peak and a Cho peak that is slightly elevated compared with the Cr peak. The NAA/Cr ratio of 2.50 and Cho/Cr ratio of 1.42 are normal.
Tables
Ratio and Voxel Patients with Developmental Delay (n = 7) Control Subjects (n = 6) P Value NAA/Cr Frontal subcortical white matter 2.11 ± 0.14 2.09 ± 0.45 NS Parieto-occipital subcortical white matter 2.08 ± 0.21 1.93 ± 0.39 NS Cho/Cr Frontal subcortical white matter 1.73 ± 0.16 1.84 ± 0.27 NS Parieto-occipital subcortical white matter 1.60 ± 0.21 1.76 ± 0.23 NS Note.—Data are the mean ± standard deviation. NS indicates not statistically significant.
Ratio and Voxel Patients with Developmental Delay (n = 7) Control Subjects (n = 6) P Value NAA/Cr Frontal subcortical white matter 2.14 ± 0.10 2.53 ± 0.15 <.001 Parieto-occipital subcortical white matter 2.06 ± 0.29 2.44 ± 0.21 <.017 Cho/Cr Frontal subcortical white matter 1.65 ± 0.22 1.37 ± 0.19 <.024 Parieto-occipital subcortical white matter 1.76 ± 0.23 1.36 ± 0.14 <.002 Note.—Data are the mean ± standard deviation.
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