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Research ArticleNeurointervention

Does Streaming Affect the Cerebral Distribution of Infraophthalmic Intracarotid Chemotherapy?

Ronit Agid, Rina Rubinstein, Tali Siegal, Hava Lester, Felix Bokstein, Roland Chisin and John M. Gomori
American Journal of Neuroradiology November 2002, 23 (10) 1732-1735;
Ronit Agid
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Rina Rubinstein
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Tali Siegal
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Hava Lester
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Felix Bokstein
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Roland Chisin
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John M. Gomori
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    Fig 1.

    A and B, Registered and normalized 99mTc-HMPAO images at the two injection rates in two different patients (A and B) in coronal (top) and axial (bottom) planes. For each patient, the images on the left are after a rapid bolus injection and those on the right are after slow continuous injection. There is no visible difference between the two rates of injection, with the exception of minimal cross-flow to the contralateral frontal area on the bolus injection images in the second patient (B).

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    Fig 2.

    A selection of subtracted and normalized axial 99mTc-HMPAO SPECT images of the patient in Fig 1A highlights a subtle increased distribution of radionuclide in the occipital region. This is due to increased cross-flow from the carotid to the posterior circulation in the rapid bolus injection.

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  • Summary of the region-of-interest size and the difference in uptake between the two injection rates for the six patients

    Size*MinimumMaximumMeanSD
    ROI A28387.049495.036137.87879.1
    ROI B87.05084.02753.31983.5
    ROI C0.214.98.46.3
    • Note.—Minimum, maximum, mean, and SD are for the region of interest (ROI) for all the examined patients.

    • * ROI A: Size (in mm2) with substantial pixel intensity (above background noise) summed for all brain sections for all patients. ROI B: Size (in mm2) with pixel intensity difference (either positive or negative) greater than 20% between the two injection rates. ROI C: The same results as in ROI B expressed as percentage of total area measured (ROI A).

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American Journal of Neuroradiology: 23 (10)
American Journal of Neuroradiology
Vol. 23, Issue 10
1 Nov 2002
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Cite this article
Ronit Agid, Rina Rubinstein, Tali Siegal, Hava Lester, Felix Bokstein, Roland Chisin, John M. Gomori
Does Streaming Affect the Cerebral Distribution of Infraophthalmic Intracarotid Chemotherapy?
American Journal of Neuroradiology Nov 2002, 23 (10) 1732-1735;

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Does Streaming Affect the Cerebral Distribution of Infraophthalmic Intracarotid Chemotherapy?
Ronit Agid, Rina Rubinstein, Tali Siegal, Hava Lester, Felix Bokstein, Roland Chisin, John M. Gomori
American Journal of Neuroradiology Nov 2002, 23 (10) 1732-1735;
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