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560 Alpha-tocopheryloxyacetic acid induces apoptosis of murine rhabdomyosarcoma in vitro while modulating innate and adaptive immune responses in vivo
Fernanda Szewc, Longzhen Song, Sean Rinella, Christopher Dubay, Emmanuel Akporiaye, William Redmond, Christian Capitini

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A338; DOI: 10.1136/jitc-2020-SITC2020.0560
566 MDK-202: An empirically-designed peptidyl agonist of the IL-2/15βγc receptor, devoid of Rα interaction, unrelated to IL-2 or IL-15, and fused to an Fc-domain for PK enhancement
William Dower, Steven Cwirla, Blake Williams, Praechompoo Pongtornpipat, Prarthana Joshi, Sandra Wang, Alice Bakker, Michael Needels, Ronald Barrett

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A340-A341; DOI: 10.1136/jitc-2020-SITC2020.0566
568 XTX201, a protein-engineered IL-2, exhibits tumor-selective activity in mice without peripheral toxicities in non-human primates
Minjie Zhang, Wilson Guzman, Parker Johnson, Megan McLaughlin, Kurt Jenkins, Hsin-Jung Wu, Hanumantha Rao Madala, Caitlin O’Toole, Magali Pederzoli-Ribeil, Raphael Rozenfeld, Huawei Qiu, Margaret Karow, Tim Clackson, Ronan O’Hagan, Jennifer O’Neil, Ugur Eskiocak

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A342; DOI: 10.1136/jitc-2020-SITC2020.0568
569 Targeting IL-15 delivery to PD-L1 expressing tumors with an Anti-PD-L1-IL-15 cytokine fusion IgM to enhance T Cell and NK Cell Mediated tumor cytotoxicity
Angus Sinclair, Thierry Giffon, Dean Ng, Poonam Yakkundi, Hope Lancero, Marigold Manlusoc, Rodnie Rosete, Avneesh Saini, Madeline Tran, Kevin Carlin, Chitra Saraiya, Ramesh Baliga, Bruce Keyt

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A342-A343; DOI: 10.1136/jitc-2020-SITC2020.0569
571 ANV419 is a novel CD122-selective IL-2/anti-IL-2 antibody fusion protein with potent CD8 T cell and NK cell stimulatory function in vitro and in vivo
Christoph Huber, Andreas Katopodis, Barbara Branetti, Jean-Michel Rondeau, Simone Popp, Catherine Regnier, Daniel Kaiser

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A343; DOI: 10.1136/jitc-2020-SITC2020.0571
573 A novel human anti-PD1/IL15 bi-functional protein with robust anti-tumor activity and low systemic toxicity
Dan Lu, Zhanna Polonskaya, Tzu-Pei Chang, Stella Martomo, Xenia Luna, Zhikai Zhang, Stanley Ng, Faical Miyara, Jeegar Patel

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A344; DOI: 10.1136/jitc-2020-SITC2020.0573
578 Tumor selective immune responses of STA551, a novel anti-CD137 agonist antibody activated by extracellular ATP
Yoshinori Narita, Mika Kamata-Sakurai

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A346-A347; DOI: 10.1136/jitc-2020-SITC2020.0578
580 High dose-rate brachytherapy of localized prostate cancer converts tumors from cold to hot
Simon Keam, Heloise Halse, ThuNgoc Nguyen, Minyu Wang, Nicolas Van Kooten Losio, Catherine Mitchell, Franco Caramia, David Byrne, Sue Haupt, Georgina Ryland, Phillip Darcy, Shahneen Sandhu, Piers Blombery, Ygal Haupt, Scott Williams, Paul Neeson

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A347-A348; DOI: 10.1136/jitc-2020-SITC2020.0580
583 Novel, potent, and selective inhibitors of hypoxia-inducible factor (HIF)-2α reverse pro-tumorigenic transcriptional programming in cancer, stromal, and immune cells
Kelsey Sivick Gauthier, Dana Piovesan, Kenneth Lawson, Soonweng Cho, Akshata Udyavar, Jean Chan, Ada Chen, Jennie Au, Cesar Meleza, Xiaoning Zhao, Anh Tran, Samuel Drew, Balint Gal, Brandon Rosen, Manmohan Leleti, Elaine Ginn, Lixia Jin, Stephen Young, Jay Powers, Matthew Walters

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A349-A350; DOI: 10.1136/jitc-2020-SITC2020.0583
582 Modulation of TCR repertoire by radiotherapy-activated NBTXR3 nanoparticles
Audrey Darmon, Ping Zhang, Sebastien Paris

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A349; DOI: 10.1136/jitc-2020-SITC2020.0582

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