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473 Mavrilimumab, a human monoclonal antibody targeting GM-CSFRα, inhibits polarization to myeloid-derived suppressor cells (MDSCs) that express PD-L1 and restores T-cell proliferation in vitro
Luis Carvajal, Luciana Gneo, Carmela De Santo, Matt Perez, Tracy Garron, Francis Mussai, Annalisa D’Andrea

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A289-A290; DOI: 10.1136/jitc-2020-SITC2020.0473
30 NLR (neutrophil lymphocyte ratio) and PLR (platelet lymphocyte ratio) changes as a predictor of eventual treatment failure and death on nivolumab therapy in renal cell carcinoma
Arnab Basu, Yash Suri, Lakshminarayan Nandagopal, Mollie Deshazo, Lyse Norian, Eddy Yang

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A29; DOI: 10.1136/jitc-2020-SITC2020.0030
476 AK119, a humanized anti-CD73 monoclonal antibody, as Immunotherapy for COVID-19
Tingting Zhong, Zhaoliang Huang, Xinghua Pang, Na Chen, Konyew Kwek, Chris Wynne, Adam Konpa, Xiaoping Jin, Yu Xia, Maxwell Zhongmin Wang, Baiyong Li, Yu Xia

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A292-A293; DOI: 10.1136/jitc-2020-SITC2020.0476
479 A lymph-node targeted amphiphile vaccine induces potent cellular and humoral immunity to SARS-CoV-2
Martin Steinbuck, Peter DeMuth, Lochana Seenappa, Christopher Haqq, Aniela Jakubowski, Lisa McNeil

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A295-A296; DOI: 10.1136/jitc-2020-SITC2020.0479
481 Impact of COVID-19 on Cancer Patients Receiving Immune Checkpoint Inhibitors
Kevin Tyan, Ai-Tram Bui, Anita Giobbie-Hurder, Isaac Klein, Michael Manos, Leyre Zubiri, Kerry Reynolds, Shilpa Grover, Gerald Weinhouse, Patrick Ott, Nicole LeBoeuf, Osama Rahma

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A296-A298; DOI: 10.1136/jitc-2020-SITC2020.0481
480 Preliminary evaluation of a novel coronavirus vaccine (CORVax) using electroporation of plasmid DNA encoding a stabilized prefusion SARS-CoV-2 spike protein alone or with transfection of plasmid IL-12
Shawn Jensen, Christopher Twitty, Christopher Paustian, Madelein Laws, Glenna McDonnell, Keith Wegmann, Tarsem Moudgil, Michael Afentoulis, Mia Han, Kellie Malloy Foerter, David Canton, Jack Lee, Bianca Nguyen, John Rodriguez, Kim Jaffe, Brian Piening, Carlo Bifulco, Daniel O’Connor, Walter Urba, Rom Leidner, Traci Hilton, Hong-Ming Hu, Bernard Fox

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A296; DOI: 10.1136/jitc-2020-SITC2020.0480
6 Pre-clinical pharmacodynamic biomarker assays of immune modulation can translate to inform exploratory endpoints of target engagement in first-in-human clinical trial stages of drug discovery
Russell Garland, Christopher Kirkham, Michelle Yap, Louise Brackenbury, Tommaso Iannitti, Robert Nunan, S Jenkinson

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A3-A4; DOI: 10.1136/jitc-2020-SITC2020.0006
49 In situ phenotypic analysis of T cells in the tumor microenvironment of a pre-clinical model of non-small cell lung cancer (NSCLC) by tissue sectioning and whole-mount immunofluorescence imaging
Elen Torres, Stefani Spranger

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A30-A31; DOI: 10.1136/jitc-2020-SITC2020.0049
486 iReceptor plus: a data integration platform to share, compare and analyze adaptive immune receptor repertoire (AIRR-seq) data from antibody/B- and T-cell repertoires
Felix Breden

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A300-A301; DOI: 10.1136/jitc-2020-SITC2020.0486
490 An immuno-oncology census: assessment of clinician knowledge and educational needs in 2020
Janelle Schrag, Fitzgerald Draper, Monique Dawkins, Lorna Lucas, Leigh Boehmer

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A302-A303; DOI: 10.1136/jitc-2020-SITC2020.0490

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