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57 Precision neoantigen discovery using novel algorithms and expanded HLA-ligandome datasets
Dattatreya Mellacheruvu, Rachel Pyke, Charles Abbott, Nick Phillips, Sejal Desai, Rena McClory, John West, Richard Chen, Sean Boyle

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A36; DOI: 10.1136/jitc-2020-SITC2020.0057
603 Covalent attachment of a TLR7/8 agonist to tumor-targeting antibodies drives potent anti-tumor efficacy by synergistically activating FcgR- and TLR- signaling and enables safe systemic administration
Shelley Ackerman, Felix Hartmann, Cecelia Pearson, Joseph Gonzalez, Po Yi Ho, Samuel Kimmey, Andrew Luo, Benjamin Ackerman, Arthur Lee, Richard Laura, Jason Paik, Karla Henning, David Jackson, Steven Chapin, Bruce Devens, David Dornan, Sean Bendall, Edgar Engleman, Michael Alonso

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A360; DOI: 10.1136/jitc-2020-SITC2020.0603
607 TJ210 (MOR210), a differentiated anti-C5aR antibody for anti-cancer therapy
Jane Meng, Zhengyi Wang, Wei Cao, Chan Chen, Joan Huaqiong Shen, Christian Augsberger, Julia Neugebauer, Stefan Haertle

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A363; DOI: 10.1136/jitc-2020-SITC2020.0607
610 Technical challenges in monocyte-derived dendritic cell vaccine manufacturing; a QI project
Opal Reddy, Sandhya Panch, Chauha Pham, Mame Thioye Sall, Minh Tran, Steven Highfill, Kamille West, Ping Jin, Haksong Jin, Malcolm Brenner, Jay Berzofsky, David Stroncek, Hoyoung Maeng

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A364-A366; DOI: 10.1136/jitc-2020-SITC2020.0610
615 Targeted immune cell activation by systemic delivery of toll-like receptor 9 agonist antibody conjugates induce potent anti-tumor immunity
Ons Harrabi, Amy Chen, Emma Sangalang, Laura Doyle, Danielle Fontaine, Bora Han, Curt Bradshaw, Jaume Pons, Janet Sim, Tracy Kuo, Hong Wan

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A369-A370; DOI: 10.1136/jitc-2020-SITC2020.0615
617 Tisotumab vedotin shows immunomodulatory activity through induction of immunogenic cell death
Elizabeth Gray, Kelly Hensley, Sean Allred, Esther Trueblood, John Gosink, Robert Thurman, Kaleb Smith, Celine Jacquemont, Mark Bieda, Jason Gow, Jeffrey Harris, Lauren Brady, Ibrahima Soumaoro, Shweta Jain, Leonardo Nicacio, Shyra Gardai

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A371-A372; DOI: 10.1136/jitc-2020-SITC2020.0617
621 A Tregs depleting, CD25-targeted antibody-drug conjugate synergizes with tumor-targeted radiotherapy and systemic interleukin-2 in pre-clinical models of solid cancers
Patrick van Berkel, Francesca Zammarchi

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A373-A374; DOI: 10.1136/jitc-2020-SITC2020.0621
622 PD-L1 is a potential predictive biomarker for response to RM-1929 treatment in recurrent head and neck squamous cell carcinoma patients
C Daniel De Magalhaes Filho, Chung-Wein Lee, Nikolai Suslov, Jerry Fong, Miguel Garcia-Guzman

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A374; DOI: 10.1136/jitc-2020-SITC2020.0622
623 Immuno-STATs: Leveraging protein engineering to expand and track antigen-specific T cells in vivo
Stad Zeigler, Andrew Woodham, Mengyan Li, Ella Zeyang, Stephen Kolifrath, Mohammad Rashidian, Kaitlyn O’Connor, Rodolfo Chaparro, Ronald Seidel, Maia Mesyngier, Ross Cheloha, Jason Dearling, Phaneendra Duddempudi, Alev Celikgil, Scott Garforth, Alan Packard, Harris Goldstein, Hidde Ploegh, Steven Almo

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A374-A375; DOI: 10.1136/jitc-2020-SITC2020.0623
624 IFNγ secreted by tebentafusp (IMCgp100)-redirected T cells inhibits expression of melanin synthesis pathway genes in healthy melanocytes
Mariantonella Vardeu, David Depoil, Camille Britton-Rivet, Jane Houghton, Jane Harper, Gabrielle Le Provost, Laura Collins, Koustubh Ranade, Adel Benlahrech

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A375; DOI: 10.1136/jitc-2020-SITC2020.0624

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