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218 A preclinical study of IMC-002, a fully human therapeutic antibody safely targeting CD47 in cancer
Hyeonseok Yoo, Jeong Kook Kim, Ji Yea Choi, Sun Kwang Song, Jihyun Park, Ara Jeon, Ji Hye Lee, Sook Kyung Chang, Yun Song

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A130; DOI: 10.1136/jitc-2020-SITC2020.0218
222 Increased PD-L1 tumor expression correlates with high rate of response to PD-1 inhibitors in patients with unresectable, recurrent, and metastatic cutaneous squamous cell carcinoma
Nate Bowers, Kimberly Burcher, Jess Savas, Phillip Williford, Laura Doerfler, Hafiz Shabbir Patwa, Joshua Waltonen, Christopher Sullivan, James Brown, Mercedes Porosnicu

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A132-A133; DOI: 10.1136/jitc-2020-SITC2020.0222
223 Racial differences in outcomes for metastatic renal cell carcinoma (mRCC) patients managed on immune-checkpoint inhibitor (ICI) therapy
T Anders Olsen, Dylan Martini, Subir Goyal, Yuan Liu, Sean Evans, Benjamin Magod, Jacqueline Brown, Lauren Yantorni, Greta Russler, Sarah Caulfield, Jamie Goldman, Bassel Nazha, Wayne Harris, Viraj Master, Omer Kucuk, Bradley Carthon, Mehmet Bilen

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A133; DOI: 10.1136/jitc-2020-SITC2020.0223
228 Radiological dynamics and resistance types in patients with advanced melanoma treated with anti-PD-1 monotherapy
Xue Bai, Michelle Kim, Gyulnara Kasumova, Lu Si, Bixia Tang, Chuanliang Cui, Xiaoling Yang, Xiaoting Wei, Justine Cohen, Donald Lawrence, Christine Freedman, Riley Fadden, Krista Rubin, Tatyana Sharova, Dennie Frederick, Keith Flaherty, Ryan Sullivan, Jun Guo, Genevieve Boland

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A136-A137; DOI: 10.1136/jitc-2020-SITC2020.0228
239 Decr2 loss promotes resistance of tumor cells to immunotherapy by affecting CD8+ T cell-regulated tumor ferroptosis
Thomas Gajewski, Emily Higgs, Shuyin Li, Blake Flood, Ken Hatogai

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A142; DOI: 10.1136/jitc-2020-SITC2020.0239
240 Identification of lung cancer mutational signatures and tumor drivers associated with specific bimodal PD-L1/TMB status
Fernando Lopez-Diaz, Lauryn Keeler, Sally Agersborg, Lawrence Weiss, Vincent Funari

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A142-A143; DOI: 10.1136/jitc-2020-SITC2020.0240
242 Monitoring MDSC – a hurdle to immune checkpoints inhibitors
Damien Montamat-Sicotte, Laetitia Cortes, Virginia Litwin, Henry Hepburne-Scott, Phoebe Bonner

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A144; DOI: 10.1136/jitc-2020-SITC2020.0242
245 Human TLR8 knock-in mice potentiate immunotherapy responses of MC38 syngeneic tumors
Shanshan Qi, Hongjuan Zhang, Ruilin Sun, Annie An, Henry Li, Davy Ouyang

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A146-A147; DOI: 10.1136/jitc-2020-SITC2020.0245
247 Assessment of sensitivity to a PD-1 check point inhibitor and cisplatin in bladder cancer patient-derived xenografts with various levels of PD-L1 expression in HuCD34NCG mice
Simon Tarpinian, Jenny Rowe, Ruziboy Husanov, Uma Saha, Prabal Banerjee, Rukiye Eraslan, Beverly Jones, Stephen Festin, Vladimir Khazak

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A147; DOI: 10.1136/jitc-2020-SITC2020.0247
248 Immunotherapy persister cells uncovered by dynamic single-cell RNA-sequencing
Kartik Sehgal, Andrew Portell, Elena Ivanova, Patrick Lizotte, Navin Mahadevan, Jonathan Greene, Amir Vadji, Carino Gurjao, Tyler Teceno, Luke Taus, Tran Thai, Shunsuke Kitajima, Derek Liu, Tetsuo Tani, Moataz Noureddine, Christie Lau, Paul Kirschmeier, David Liu, Marios Giannakis, Russell Jenkins, Prafulla Gokhale, Silvia Goldoni, Maria Pinzon-Ortiz, William Hastings, Peter Hammerman, Juan Miret, Cloud Paweletz, David Barbie

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A149-A150; DOI: 10.1136/jitc-2020-SITC2020.0248

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