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395 A first-in-human study of FS118, a tetravalent bispecific antibody targeting LAG-3 and PD-L1, in patients with advanced cancer and resistance to PD-(L)1 therapy
Timothy Yap, Deborah Wong, Siwen Hu-Lieskovan, Kyriakos Papadopoulos, Michelle Morrow, Urszula Grabowska, Daniel Gliddon, Josefin-Beate Holz, Patricia LoRusso

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A240; DOI: 10.1136/jitc-2020-SITC2020.0395
397 Intra-tumor immunotherapy injections utilizing image guidance in interventional radiology: clinical trial experience at a tertiary care cancer center
Ravi Murthy, Rahul Sheth, Alda Tam, Sanjay Gupta, Vivek Subbiah, Filip Janku, Timothy Yap, Adi Diab, Aung Naing, Sapna Patel, Funda Meric-Bernstam

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A241-A242; DOI: 10.1136/jitc-2020-SITC2020.0397
401 Phase 1/2 study of novel HER2-targeting, TLR7/8 immune-stimulating antibody conjugate (ISAC) BDC-1001 with or without immune checkpoint inhibitor in patients with advanced HER2-expressing solid tumors
Manish Sharma, Ecaterina Ileana Dumbrava, Richard Carvajal, Daniel Catenacci, Leisha Emens, Glenn Hanna, Dejan Juric, Yoon-Koo Kang, Jeeyun Lee, Keun-Wook Lee, Bob Li, Kathleen Moore, Mark Pegram, Paula Pohlmann, Drew Rasco, Alexander Spira, Antoinette Tan, Ding Wang, Shelley Ackerman, Heidi LeBlanc, David Dornan, Marcin Kowanetz, Michael Alonso, Edith Perez, Edith Perez

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A244; DOI: 10.1136/jitc-2020-SITC2020.0401
407 Preliminary safety, pharmacokinetics/pharmacodynamics, and antitumor activity of XmAb20717, a PD-1 x CTLA-4 bispecific antibody, in patients with advanced solid tumors
Elaine Shum, Adil Daud, Matthew Reilley, Yana Najjar, John Thompson, Joaquina Baranda, R Donald Harvey, Rom Leidner, Anthony Shields, Ezra Cohen, Roger Cohen, Alain Mita, Shubham Pant, Mark Stein, Bartosz Chmielowski, Siwen Hu-Lieskovan, Catherine Fleener, Ying Ding, Sowmya Chollate, Hector Avina, Jolene Shorr, Raphael Clynes, Barbara Hickingbottom

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A247-A248; DOI: 10.1136/jitc-2020-SITC2020.0407
42 Intravital multiphoton microscopy of infiltrating T cell and tumor cell metabolism in a murine melanoma model
Alexa Heaton, Tiffany Heaster, Anna Hoefges, Alexander Rakhmilevich, Amy Erbe, Paul Sondel, Melissa Skala

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A25; DOI: 10.1136/jitc-2020-SITC2020.0042
413 GEN-009, a personalized neoantigen vaccine, elicits robust immune responses in individuals with advanced or metastatic solid tumors
Mara Shainheit, Devin Champagne, Gabriella Santone, Syukri Shukor, Ece Bicak, Samuel Tipps, Li Xue, Thomas Davis, Jessica Flechtner

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A251; DOI: 10.1136/jitc-2020-SITC2020.0413
44 Body composition may be prognostic and predictive of clinical outcomes in metastatic renal cell carcinoma (mRCC) patients treated with immune checkpoint inhibitors (ICI)
Dylan Martini, T Anders Olsen, Subir Goyal, Yuan Liu, Sean Evans, Benjamin Magod, Jacqueline Brown, Lauren Yantorni, Greta Russler, Sarah Caulfield, Jamie Goldman, Bassel Nazha, Wayne Harris, Omer Kucuk, Bradley Carthon, Viraj Master, Mehmet Bilen

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A26-A27; DOI: 10.1136/jitc-2020-SITC2020.0044
451 Combining Bempegaldesleukin (CD122-preferential IL-2 pathway agonist) and NKTR-262 (TLR7/8 agonist) pairs local innate activation with systemic CD8+ T cell expansion to enhance anti-tumor immunity
Annah Rolig, Daniel Rose, Saul Kivimae, Werner Rubas, William Redmond

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A274; DOI: 10.1136/jitc-2020-SITC2020.0451
46 A novel H&E-like staining method compatible with multiplexed IF on the same tissue section for integrated translational workflows
Michael McLane, Glenn Milton, Linying Liu, Rachel Schaefer, Yi Zheng, Carla Coltharp, Peter Miller, Clifford Hoyt

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A29; DOI: 10.1136/jitc-2020-SITC2020.0046
47 Pathologists enhance interpretation of automated multiplex immunohistochemistry assays in cancer immunotherapy trials
Emmanuel Pacia, Xun Li, Ju Young Kim, Evelyn Diaz, Beiru Chen, Nathan Roscoe, Jason Hughes, Thai Tran, Jennifer Bordeaux, Bashar Dabbas, Shabnam Tangri, Margaret McLaughlin, Alexander Savchenko, Naveen Dakappagari

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A29; DOI: 10.1136/jitc-2020-SITC2020.0047

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