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997 The CD16 L48H/R polymorphism enables more compact receptor clustering and enhances natural killer cell-mediated antibody-dependent cellular cytotoxicity
Nicholas Maskalenko, Sam Zahroun, Nadia Anikeeva, Yuri Sykulev, Kerry Campbell

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1105; DOI: 10.1136/jitc-2023-SITC2023.0997
998 Identification of the role of oncometabolites on natural killer cell in the tumor microenvironment by CRISPR screening
Sandro Matosevic, Xinyu Wu

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1106; DOI: 10.1136/jitc-2023-SITC2023.0998
999 The PTPN2/N1 small molecule inhibitor ABBV-CLS-484 promotes NK cell activity driving primary tumor regression and preventing metastasis
Chirag Patel, Kathleen A McGuire, Hakimeh Ebrahimi-Nik, Meng Sun, Yue Liu, Kelly Klinge, Jacqueline Aguado, Audrey J Muscato, Payal Tiwari, Omar Avila-Monge, Kayla J Colvin, Kira Olander, Kyle Halliwill, Joseph Klahn, Alexander Schutte, Marcia N Paddock, Jonathan Powell, Keith M Hamel, Jennifer M Frost, Kathleen B Yates, Philip R Kym, Robert T Manguso, Christina K Baumgartner

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1107; DOI: 10.1136/jitc-2023-SITC2023.0999
1000 Adaptive NK cells with distinct features possess immune memory towards ovarian tumors
Yizhe Sun, Andrea Rodgers-Furones, Sayaka Suzuki, Okan Gultekin, Lidia Galceran, Sahar Salehi, Kaisa Lehti, Dhifaf Sarhan

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1108; DOI: 10.1136/jitc-2023-SITC2023.1000
1001 CAT-248 (engineered NK cells expressing CD70 CAR, IL15, and TGFβ DNR) demonstrates in vivo expansion, tumor infiltration, and durable regression of multiple CD70-expressing xenograft tumors
Vipin Suri, Bashar Hamza, Angela Nunez, Henry Moreno, Marilyn Marques, Alexia Barandiaran, Evelyn Warren, Cristina Panaroni, Michele McAuliffe, Krista Daniel, Julianne Murthy, Keith HK Wong, Mark Omobono, Priya Khurana, Beatriz Marques, Adriana Rivera, Jae Woong Chang, Branden Moriarity, Joseph Gold, Cherry Thomas, Dominic Picarella

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1109; DOI: 10.1136/jitc-2023-SITC2023.1001
1002 Intratumor heterogeneity in MHC-I expression drives immunotherapy resistance and exposes NKG2A as a therapeutic target in breast cancer
Brandie C Taylor, Xiaopeng Sun, Paula Gonzalez Ericsson, Violeta Sanchez, Melinda Sanders, Elizabeth Wescott, Susan Opalenik, Ann Hanna, Brian Lehmann, Vandana Abramson, Jennifer Pietenpol, Justin M Balko

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1110; DOI: 10.1136/jitc-2023-SITC2023.1002
1003 TIM-3+ natural killer cell dysfunction is driven by galectin-9 in head and neck squamous cell carcinoma
Juncheng Wang, Housaiyin Li, Aditi Kulkarni, Jennifer Anderson, Lidia Arantes, Hridesh Banerjee, Lawrence P Kane, Xin Zhang, Tullia Bruno, Riyue Bao, Robert Ferris, Lazar Vujanovic

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1111; DOI: 10.1136/jitc-2023-SITC2023.1003
1004 Immune checkpoint blockade unleashes mucosal associated invariant T (MAIT) cells in tumor microenvironment of NSCLC patients
Pakhi Birla, Lansaol Yang, Alex Lee, Boyang Zhang, Kellie N Smith, Cynthia Sears, Fyza Shaikh, Franck Housseau, Drew Pardoll

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1112; DOI: 10.1136/jitc-2023-SITC2023.1004
1005 BiXAb® MAIT Engagers: solving the problems of classical T-cell engagers in the treatment of solid tumors
Simon E Plyte, Marie Fraudeau, Claire Germain, Dorothee Winterberg, Camille Rousseau, Gaetano Sodaro, Maxime Audin, Alexandre Ivagnes, Hans Heinrich Oberg, Pierre Emmanuel Gerard, Daniela Wesch, Matthias Peipp, Julie Prigent

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1113; DOI: 10.1136/jitc-2023-SITC2023.1005
1006 High doses of MHC-II neoantigens in peptide cancer vaccines induce tumor-specific inhibitory cytolytic CD4⁺ T cells
Hussein Sultan, Yoshiko Takeuchi, Jeffrey Ward, Maria Firulyova, Tian-Tian Liu, Naveen Sharma, Yuang Song, Samuel Ameh, Vladimir Sukhov, Corazon Arthur, Andres Salazar, Kelly D Moynihan, Yik Andy Yeung, Ivana Djuretic, Ton Schumacher, Kathleen Sheehan, Marco Colonna, James Allison, Kenneth Murphy, Maxim Artyomov, Robert Schreiber

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1114; DOI: 10.1136/jitc-2023-SITC2023.1006

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