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956 Glioma-neuronal circuit remodeling induces regional immunosuppression
Takahide Nejo, Saritha Krishna, Akane Yamamichi, Christian Jimenez, Jacob S Young, Senthilnath Lakshmanachetty, Tiffany Chen, Su Phyu, Payal Watchmaker, Abrar Choudhury, David R Raleigh, Shawn L Hervey-Jumper, Hideho Okada

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1062-A1063; DOI: 10.1136/jitc-2023-SITC2023.0956
957 The ATR-inhibitor ceralasertib modulates the tumor microenvironment and improves the effect of anti-PDL1 by activating type I IFN pathway
Emilio Sanseviero, Devon Taylor, Sehmus Tohumeken, Mimi Mai, Ali Mostafa, Marta Milo, Kathy Mulgrew, Simon Barry, Serge Fuchs, Mark Cobbold, Dmitry Gabrilovich

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1064; DOI: 10.1136/jitc-2023-SITC2023.0957
958 Simplifying high-parameter phenotypic and functional characterization of cancer immune cells
Deeqa Mahamed, Geneve Awong, Leslie Fung, Christina Loh

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1065; DOI: 10.1136/jitc-2023-SITC2023.0958
959 Multiomic characterization of the tumor microenvironment in FFPE tissue by simultaneous protein and gene expression profiling
Jun Chiang, Ace Santiago, Alexander Hermes, Anuj Patel, Benton Veire, David Sukovich, Hardeep Singh, Lauren Gutgesell, Stephen Williams, Augusto Tentori

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1066; DOI: 10.1136/jitc-2023-SITC2023.0959
960 Chromium Flex enables scFFPE-Seq and single cell-spatial data integration from human tumor blocks
Tingsheng Y Drennon, Jawad Abousoud, Ryan Stott, Juan Pablo Romero, Paul Lund, Sarah Taylor, Peter Smibert, Andrew Kohlway

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1067; DOI: 10.1136/jitc-2023-SITC2023.0960
962 Single-cell spatial in situ transcriptomics unravels vulvar HSIL composition associated with complete response to therapeutic vaccination
Ziena Abdulrahman, Mariette van Poelgeest, Marij Welters, Sjoerd Van der Burg

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1069; DOI: 10.1136/jitc-2023-SITC2023.0962
963 TME Immune-profiling of ex vivo tumor tissues and their functional responses to immuno-oncology treatments
Sander Basten, Talita Stessuk, Ezgi Kaya Aksoy, Niels Meesters, Kuan Yan, Emma Spanjaard, Leo Price, Nataliia Beztsinna

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1070; DOI: 10.1136/jitc-2023-SITC2023.0963
964 Single-cell spatial characterization of microenvironmental impacts on immunotherapy discrepancies between adult and pediatric nasopharyngeal carcinoma patients
Lanqi Gong, Yu Zhang, Grace Guan, Beibei Ru, Peng Jiang, Xin-Yuan Guan

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1071; DOI: 10.1136/jitc-2023-SITC2023.0964
965 NFAT2 drives the cytoskeletal remodeling of leukemia cells, which regulates their vulnerability to perforin-mediated killing
Samuel Holzmayer, Jonas Mauermann, Sarah Maria Greiner, Jonas S Heitmann, Kuebra Kaban, Helmut R Salih, Melanie Märklin

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1072; DOI: 10.1136/jitc-2023-SITC2023.0965
966 Spatial profiling of the metastatic castration resistant prostate cancer tumor microenvironment at the single cell level reveals insights into intrinsic resistance to immunotherapy
Ana Lako, Andrew Fisher, Anne Lewin, Katharine Barrientos, Benjamin Chen

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1073; DOI: 10.1136/jitc-2023-SITC2023.0966

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