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977 Development of a non-small cell lung cancer PDX model in a myeloid-boosted humanized host highlights a M2 polarization phenotype within the myeloid compartment
Mara Gilardi, Nektaria Papadopoulou, Brandon Walling, Sebastian Brabetz, Alex Moreau, David DeOrnellis, Stefano Cairo, Kiave Yune Ho Wang Yin, Marianna Zipeto

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1084; DOI: 10.1136/jitc-2023-SITC2023.0977
978 Stage-appropriate bioassays for assessing ADCP activity of therapeutic antibodies
Julia K Gilden, Jonathan Mitchell, Pete Stecha, Jim Hartnett, Jamison Grailer, Frank Fan, Mei Cong

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1085; DOI: 10.1136/jitc-2023-SITC2023.0978
979 Phagocytosis increases an oxidative metabolic and immune suppressive signature in tumor macrophages
Michael Gonzalez, Daniel Lu, Chen Hao Lo, Maryam Yousefi, Ashley Kroll, Monte Winslow, Kristin Tarbell

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1086; DOI: 10.1136/jitc-2023-SITC2023.0979
980 Prognostic significance of M1/M2 tumor-associated macrophages with pigmentation in uveal melanoma
Jayanti Jha, Lata Singh, Mithalesh Singh, Rachna Meel, Neelam Pushker, Neiwete Lomi, Aanchal Kakkar, Seema Sen, Seema Kashyap

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1087; DOI: 10.1136/jitc-2023-SITC2023.0980
981 AXL-targeted macrophage phenotype switching mediates checkpoint-resistance in melanoma
Amanda Kirane-c, Saurabh Sharma, Mamatha Serasanambati, Mohammad Usman Ahmad, Chris Applebee, Elena Safrygina, Nathan E Reticker-Flynn, Jessica Fessler, Alexander Merleev, Edgar G Engleman, Emanual Maverakis, Banafshe Larijani

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1088; DOI: 10.1136/jitc-2023-SITC2023.0981
982 Immune mediated mechanisms of PARPi resistance in BRCA1-associated triple negative breast cancer (TNBC)
Adam Nelson, Anita Mehta, Madeline G Townsend, Madisson Oliwa, Kelly F Zheng, Patrice A Lee, Nicholas A Saccomano, Filipa Lynce, Nabihah Tayob, Geoffrey I Shapiro, Jennifer L Guerriero

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1089; DOI: 10.1136/jitc-2023-SITC2023.0982
983 Syk promotes macrophage immunosuppressive phenotype to suppress anti-tumor immunity
Deepak Rohila, Suresh Madheswaran, Shweta Joshi

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1090; DOI: 10.1136/jitc-2023-SITC2023.0983
984 Using sex differences to uncover novel microglia regulators of glioblastoma progression
Marla E Tharp, Claudia Z Han, Christopher K Glass, David C Page

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1091; DOI: 10.1136/jitc-2023-SITC2023.0984
985 PSGL-1 is a novel inhibitor of tumor cell phagocytosis by macrophages
Lok San Wong, Andre Veillette

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1092; DOI: 10.1136/jitc-2023-SITC2023.0985
986 Distinct macrophage metabolism and phenotypic changes in viral and non-alcoholic fatty liver disease (NAFLD) related hepatocellular carcinoma
Junzhe Zhao, NEO Shiyong, See Voon Seow, Timothy WH Shuen, Farah Tasnim, Antoinette SW Fong, Caroline G Lee, Hanry Yu, Han Chong Toh

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1093; DOI: 10.1136/jitc-2023-SITC2023.0986

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