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934 Mechanisms of immune escape in NF1-associated peripheral nerve sheath tumors
Lindy Zhang, Alexandre Maalouf, Ana Calizo, Aditya Suru, Stavriani Makri, Jineta Banerjee, John Gross, Christine Pratilas, Nicolas Llosa

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1038; DOI: 10.1136/jitc-2023-SITC2023.0934
935 VISTA regulates the differentiation of myeloid-derived suppressor cells by STAT3-dependent modulation of arginase-1 and iNOS expression and mitochondrial function
Keman Zhang, Amin Zakeri, Tyler Alban, Juan Dong, Hieu Ta, Ajay Zalavadia, Andrelie Branicky, Haoxin Zhao, Ivan Juric, Hanna Husich, Prerana Parthasarathy, Amit Rupani, Judy Drazba, Abhishek Chakraborty, Stanley Huang, Timothy Chan, Stefanie Avril, Li Wang

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1039; DOI: 10.1136/jitc-2023-SITC2023.0935
936 Post neoadjuvant chemotherapy tissues enriched in a distinct CD27⁻IgD⁻CD21^-CXCR5^- atypical double negative (DN)2 B cells, with potential role in purinergic signalling in early breast cancers
Esme Carpenter, Paul Buckley, Thanussuyah Alaguthurai, Rosalind Graham, Helen Kakkassery, Gheed Alhity, Farhana Hossain, Sadiyah Mukhtar, Sheeba Irshad

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1040; DOI: 10.1136/jitc-2023-SITC2023.0936
937 Comprehensive immune profiling unravels evolution of spatial distribution and immune repertoire in tumor microenvironment from primary to metastatic triple negative breast cancers
Weihua Guo, Colt Egelston, Katherine Hutchinson, Jennifer M Giltnane, Veronica Ibarra, Bonnie Liu, Daniel Schmolze, Susan Yost, Yuan Yuan

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1041; DOI: 10.1136/jitc-2023-SITC2023.0937
939 Unique profile of memory-derived regulatory B cells in viral-driven hepatocellular carcinoma
Shiyong Neo, Kong-Peng Lam

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1042; DOI: 10.1136/jitc-2023-SITC2023.0939
940 High plasma cell presence in oral cancers with high frequencies of tumor-infiltrating B cells identified by transcriptional, flow cytometric and spatial profiling
Dennis NLM Nijenhuis, Tara Muijlwijk, Sonja H Ganzevles, Stina Lie Hansson, Anabel van der Lee, Irene Nauta, C Rene Leemans, Ruud H Brakenhoff, Rieneke van de Ven

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1043; DOI: 10.1136/jitc-2023-SITC2023.0940
941 Tumour draining lymph nodes contain immunosuppressive B cell phenotypes
Krzysztof Piersiala, Vilma Lagebro, Eric Hjalmarsson, Pedro Farrajota Neves da Silva, Aeneas Kolev, Magnus Starkhammar, Alexandra Elliot, Linda Marklund, Eva Munck-Wikland, Gregori Margolin, Susanna Kumlien Georén, Lars Cardell

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1044; DOI: 10.1136/jitc-2023-SITC2023.0941
943 Glutamine synthetase inhibition alters CD8+ T cell metabolism and function
Emilie Fisher, Jeffrey Rathmell

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1045; DOI: 10.1136/jitc-2023-SITC2023.0943
944 Obese, not starving: mitochondrial citrate export drives lipid accumulation and dysfunction in exhausted T cells
Kellie Spahr, Nicole Scharping, Bingxian Xie, Greg Delgoffe

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1046; DOI: 10.1136/jitc-2023-SITC2023.0944
945 Dendritic cell-intrinsic PTPN22 negatively regulates anti-tumor immunity and impacts anti-PD-L1 efficacy
Santiago Acero Bedoya, Emily Higgs, Anna Martinez, Thomas Gajewski

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1047; DOI: 10.1136/jitc-2023-SITC2023.0945

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