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1168 Identification of fully human TCR-mimic antibodies targeting the KRAS G12V/HLA complex generated in HLA-transgenic RenMab^TM mice
Jun Du, Wanbo Tang, Xin Jiao, Limin Zhao, Pengfei Du, Yuqi Zhang, Yue Zhang, Han Chen, Jian Bao, Aijing Niu, W Frank An, Chaoshe Guo, Baihong Liu, Yi Yang

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1287; DOI: 10.1136/jitc-2023-SITC2023.1168
1169 AZD5863: a specific, potent, affinity-optimized claudin 18.2 and CD3 binding T cell-engager that elicits low cytokine release and is capable of bystander killing
Miguel Gaspar, Marina Natoli, Laure Castan, Sharif Rahmy, Cathryn Kelton, Kathy Mulgrew, Martin Korade, Oisin Huhn, D Gareth Rees, Anna Sigurdardottir, Christopher Lloyd, Yun He, Yiping Rong, Kristen Pollizzi, Scott Hammond, Saso Cemerski, Simon Dovedi, Mark Cobbold, Benjamin Ridgway, Maria AS Broggi, Douglas C Palmer, Kathryn Ball, Mary McFarlane, Fred Arce Vargas, Natalia Ceaicovscaia, Gayle Pouliot, Philip Szekeres, Jonathan Fitzgerald, Rakesh Kumar

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1288; DOI: 10.1136/jitc-2023-SITC2023.1169
1170 Development of a fusion protein bispecific for a CMV-specific TCR and CD19 which selectively activates and expands CMV-specific CTLs and redirects them to eliminate B cell leukemia cells
Christopher R Hiner, Scott Garforth, Steven Almo, Harris Goldstein

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1289-A1290; DOI: 10.1136/jitc-2023-SITC2023.1170
1171 CLN-418, a clinical-stage B7H4 x 4–1BB bispecific antibody with potential to treat patients with a wide range of solid tumors
Ella Ioffe, Naveen K Mehta, Kristan A Meetze, Irina M Shapiro, Hanna Dobrowolska, Bing Huang, Yun He, Patrick A Baeuerle, Jennifer S Michaelson

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1291; DOI: 10.1136/jitc-2023-SITC2023.1171
1172 SAIL66, a next generation of T cell engager targeting CLDN6, potentiates efficacy
Takayuki Kamikawa, Naoki Kimura, Shinya Ishii, Masaru Muraoka, Kenji Taniguchi, Ryo Uchikawa, Moe Yoshimoto, Momoko Okuda-Miura, Sho Akai, Tatsushi Kodama, Hirofumi Sakumoto, Shigeto Kawai, Mei Shimada, Mika Kamata-Sakurai, Hiroyuki Aburatani, Takehisa Kitazawa, Tomoyuki Igawa

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1292; DOI: 10.1136/jitc-2023-SITC2023.1172
1173 GNUV205, a bifunctional protein of engineered IL-2 fused with a novel anti-PD1 antibody, exhibits superior tumor suppressing efficacy in vivo
June Myoung Kim, Eunju Choi, Kwanghyun Lee, Hak-Jun Jung, Hyun Soo Shin, Jenny Choih, Heungrok Park, Sungho Han, Donggoo Bae

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1293; DOI: 10.1136/jitc-2023-SITC2023.1173
1174 Costimulatory IgM T-cell engagers with enhanced and durable cytotoxicity
Keyu Li, Jie Xue, Deepal Pandya, Poonam Yakkundi, Gene Li, Kristene Mai, Nardeen Hanna, Zhongde Ye, Rodnie Rosete, Jinqiu Wang, Tina Mao, Vidhya Bai Krishnoji Rao, Elizabeth Perez, Palak Chudasama, Yue Wang, Sachi Rahman, Zee Malik, Paul Hinton, Krzysztof Bzymek, Bruce Keyt, Liqin Liu, Angus Sinclair, Umesh Muchhal

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1294; DOI: 10.1136/jitc-2023-SITC2023.1174
1175 YH006, a fully human Treg-depleting CTLA-4×OX40 bispecific antibody, demonstrates superior preclinical efficacy and favorable developability
Baihong Liu, Xiang Guo, Yanfei Han, Jing Zhang, W Frank An, Chaoshe Guo, Lei Zhang, Yi Yang

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1295; DOI: 10.1136/jitc-2023-SITC2023.1175
1176 BSI-510, a novel bispecific molecule combining an anti-Siglec-15 antibody with cytokine GM-CSF for enhanced antitumor efficacy
Zemeng Ma, Xiaoyao Hao, Xiaodong F Liu, Hongyan Li, Wenwen Dai, Yuxiang Liu, Jinyu Liu, Shukai Xia, Mark Z Ma, Mingjiu Chen, Zeyu Peng

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1296; DOI: 10.1136/jitc-2023-SITC2023.1176
1177 Multifunctional natural killer cell engager releasing CXCL10 augments natural killer cell recruitment and anti-tumor efficacy against glioblastoma
Sandro Matosevic, Xue Yao

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1297; DOI: 10.1136/jitc-2023-SITC2023.1177

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