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1247 Gene signature predict autoimmune toxicity in patients with metastatic melanoma
Domenico Mallardo, Mario Fordellone, Michael Bailey, Marilena Tuffanelli, Andrew White, Ester Simeone, Lucia Festino, Vito Vanella, Claudia Trojaniello, Maria Grazia Vitale, Margaret Ottaviano, Francesca Sparano, Bianca Arianna Facchini, Ernesta Cavalcanti, Sarah Church, Corrado Caraco, Alessandra Cesano, Alfredo Budillon, Sarah Warren, Paolo Chiodini, Paolo Ascierto

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1379; DOI: 10.1136/jitc-2023-SITC2023.1247
1248 Myeloid cells contribution is key to reproduce CRS pathophysiology induced by T cell engagers in BRGSF-HIS model
Perrine Martin-Jeantet, Alexis Gonon, Gaelle Martin, Fabiane Sonego, Yacine Cherifi, Kader Thiam

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1380; DOI: 10.1136/jitc-2023-SITC2023.1248
1249 Development of novel preclinical model that recapitulate immunotherapy induced immune related adverse events observed in the clinics
Onyekachi Okpasuo, Diana Gil

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1381; DOI: 10.1136/jitc-2023-SITC2023.1249
1250 Molecular predictors and mechanisms of immune checkpoint inhibitor-induced myocarditis: a case-control study with translational correlates
Steph A Pang, Manuel Flores Molina, Paméla Thébault, Hsiang Chou, Christophe Goncalves, Paulo Nunes Filho, Sabin Filimon, Tingting Chen, Lucas A Salas, Khashayar Esfahani, Caroline M Michel, Jun Ding, Sonia VDel Rincon, Marie Hudson, Réjean Lapointe, Wilson H Miller

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1382-A1385; DOI: 10.1136/jitc-2023-SITC2023.1250
1251 Seasonal and geographic patterns in cutaneous immune-related adverse events after treatment with immune checkpoint inhibitors: a multicenter analysis
Ahmad Rajeh, Katie Roster, Wenxin Chen, Guihong Wan, Kerry Reynolds, Nicole R Leboeuf, Shawn Kwatra, Yevgeniy R Semenov

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1386-A1387; DOI: 10.1136/jitc-2023-SITC2023.1251
1252 Immune checkpoint inhibitor-induced diabetes mellitus comprises multiple clinical endotypes with distinct immunologic features
Michelle Rengarajan, Karina Ruiz Esteves, Sergio Aguilar Fernandez, Kaitlyn Shank, Aaron Deutsch, Leyre Zubiri, Caitlin Colling, Hoang Tran, Alekhya Gunturi, John McGuire, Alice Tirard, Benjamin Arnold, Nandini Samanta, Sidney Martin, Katherine Perlman, Tianqi Ouyang, Alexander Gusev, Dejan Juric, Genevieve M Boland, Meghan Sise, Kerry Reynolds, Alexandra-Chloe Villani

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1388; DOI: 10.1136/jitc-2023-SITC2023.1252
1254 Tumor-mediated education of bone marrow neutrophil progenitors facilitates the development of checkpoint inhibitor-associated toxicity
Bala Thievanthiran, Nagendra Yarla, Michael Plebanek, Michelle Ferreira, Y-Van Nguyen, Kaylee Howell, Nicholas DeVito, Brent A Hanks

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1389; DOI: 10.1136/jitc-2023-SITC2023.1254
1255 Single cell dissection of human checkpoint inhibitor hepatitis reveals insights into liver immune tolerance
Molly Thomas, Tos Chan, Neal Smith, Shreyash Sonthalia, Marc Sherman, Swetha Ramesh, Alice Tirard, John McGuire, Mazen Nasrallah, Kasidet Manakongtreecheep, Jessica Tantivit, Leyre Zubiri, Dejan Juric, Ryan Sullivan, Nir Hacohen, Genevieve M Boland, Georg Lauer, Kerry Reynolds, Alexandra-Chloe Villani

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1390; DOI: 10.1136/jitc-2023-SITC2023.1255
1256 IL-1ß blockade mitigates immunotherapy-induced gut toxicity and promotes antitumor response
Glenn Winn, Noha Abdel-Wahab, Michael A Davies, Adi Diab, Yared Hailemichael

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1391; DOI: 10.1136/jitc-2023-SITC2023.1256
1257 Augmenting post-market surveillance of serious drug-induced adverse events with artificial intelligence (AI)-aggregated case reports: proof-of-concept for PD-1/PD-L1 inhibitors for NSCLC
Suad Kabbaha, Sarah Dempsey, Aranka Anema, Sonal Singh, Kristian Thorlund

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1392; DOI: 10.1136/jitc-2023-SITC2023.1257

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