Basic Tumor Immunology

Deep immune profiling reveals targetable mechanisms of immune evasion in immune checkpoint inhibitor-refractory glioblastoma
Erin F Simonds, Edbert D Lu, Oscar Badillo, Shokoufeh Karimi, Eric V Liu, Whitney Tamaki, Chiara Rancan, Kira M Downey, Jacob Stultz, Meenal Sinha, Lauren K McHenry, Nicole M Nasholm, Pavlina Chuntova, Anders Sundström, Vassilis Genoud, Shilpa A Shahani, Leo D Wang, Christine E Brown, Paul R Walker, Fredrik J Swartling, Lawrence Fong, Hideho Okada, William A Weiss, Mats Hellström

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002181; DOI: 10.1136/jitc-2020-002181
Follicular helper-T cells restore CD8⁺-dependent antitumor immunity and anti-PD-L1/PD-1 efficacy
Julie Niogret, Hélène Berger, Cédric Rebe, Romain Mary, Elise Ballot, Caroline Truntzer, Marion Thibaudin, Valentin Derangère, Christophe Hibos, Léa Hampe, David Rageot, Théo Accogli, Philippe Joubert, Bertrand Routy, James Harker, Frederique Vegran, Francois Ghiringhelli, Fanny Chalmin

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002157; DOI: 10.1136/jitc-2020-002157
Heterogeneity in tertiary lymphoid structure B-cells correlates with patient survival in metastatic melanoma
Kevin T Lynch, Samuel J Young, Max O Meneveau, Nolan A Wages, Victor H Engelhard, Craig L Slingluff Jr, Ileana S Mauldin

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002273; DOI: 10.1136/jitc-2020-002273
Protein citrullination as a source of cancer neoantigens
Hiroyuki Katayama, Makoto Kobayashi, Ehsan Irajizad, Alejandro M Sevillano, Nikul Patel, Xiangying Mao, Leona Rusling, Jody Vykoukal, Yining Cai, Fuchung Hsiao, Chuan-Yih Yu, James Long, Jinsong Liu, Franscisco Esteva, Johannes Fahrmann, Sam Hanash

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002549; DOI: 10.1136/jitc-2021-002549
Mesoporous silica nanoparticles inflame tumors to overcome anti-PD-1 resistance through TLR4-NFκB axis
Mayu Sun, Pengfei Gu, Yang Yang, Luodan Yu, Zheshun Jiang, Jingquan Li, Yingying Le, Yu Chen, Qian Ba, Hui Wang

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002508; DOI: 10.1136/jitc-2021-002508
IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms
Qi Wu, Ai-Ling Tian, Bei Li, Marion Leduc, Sabrina Forveille, Peter Hamley, Warren Galloway, Wei Xie, Peng Liu, Liwei Zhao, Shuai Zhang, Pan Hui, Frank Madeo, Yi Tu, Oliver Kepp, Guido Kroemer

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002722; DOI: 10.1136/jitc-2021-002722
Checkpoint blockade accelerates a novel switch from an NKT-driven TNFα response toward a T cell driven IFN-γ response within the tumor microenvironment
Shota Aoyama, Ryosuke Nakagawa, Satoshi Nemoto, Patricio Perez-Villarroel, James J Mulé, Adam William Mailloux

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002269; DOI: 10.1136/jitc-2020-002269
IL-6 contributes to metastatic switch via the differentiation of monocytic-dendritic progenitors into prometastatic immune cells
Ksenia Magidey-Klein, Tim J Cooper, Ksenya Kveler, Rachelly Normand, Tongwu Zhang, Michael Timaner, Ziv Raviv, Brian P. James, Roi Gazit, Ze'ev A. Ronai, Shai Shen-Orr, Yuval Shaked

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002856; DOI: 10.1136/jitc-2021-002856
S100A4 enhances protumor macrophage polarization by control of PPAR-γ-dependent induction of fatty acid oxidation
Shuangqing Liu, Huilei Zhang, Yanan Li, Yana Zhang, Yangyang Bian, Yanqiong Zeng, Xiaohan Yao, Jiajia Wan, Xu Chen, Jianru Li, Zhaoqing Wang, Zhihai Qin

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002548; DOI: 10.1136/jitc-2021-002548
Effect of cabazitaxel on macrophages improves CD47-targeted immunotherapy for triple-negative breast cancer
Xu Cao, Bolei Li, Jing Chen, Jessica Dang, Siqi Chen, E Gulsen Gunes, Bo Xu, Lei Tian, Sabina Muend, Mustafa Raoof, Christiane Querfeld, Jianhua Yu, Steven T. Rosen, Yingyu Wang, Mingye Feng

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e002022; DOI: 10.1136/jitc-2020-002022

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