Basic Tumor Immunology

Loss of secreted gelsolin enhances response to anticancer therapies
Kok Haw Jonathan Lim, Evangelos Giampazolias, Oliver Schulz, Neil C Rogers, Anna Wilkins, Erik Sahai, Jessica Strid, Caetano Reis e Sousa

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e005245; DOI: 10.1136/jitc-2022-005245
Tumorous expression of NAC1 restrains antitumor immunity through the LDHA-mediated immune evasion
Yijie Ren, Anil Kumar, Jugal K Das, Hao-Yun Peng, Liqing Wang, Darby Balllard, Xiaofang Xiong, Xingcong Ren, Yi Zhang, Jin-Ming Yang, Jianxun Song

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e004856; DOI: 10.1136/jitc-2022-004856
Complement downregulation promotes an inflammatory signature that renders colorectal cancer susceptible to immunotherapy
Carsten Krieg, Lukas M Weber, Bruno Fosso, Marinella Marzano, Gary Hardiman, Monica M Olcina, Enric Domingo, Sahar El Aidy, Khalil Mallah, Mark D Robinson, Silvia Guglietta

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e004717; DOI: 10.1136/jitc-2022-004717
T cell-intrinsic STING signaling promotes regulatory T cell induction and immunosuppression by upregulating FOXP3 transcription in cervical cancer
Huanhe Ni, Huanling Zhang, Lin Li, He Huang, Hui Guo, Lin Zhang, Chunwei Li, Jing-Xiao Xu, Cai-Ping Nie, Kui Li, Xiaoshi Zhang, Xiaojun Xia, Jiang Li

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e005151; DOI: 10.1136/jitc-2022-005151
HSP90α induces immunosuppressive myeloid cells in melanoma via TLR4 signaling
Ihor Arkhypov, Feyza Gül Özbay Kurt, Rebekka Bitsch, Daniel Novak, Vera Petrova, Samantha Lasser, Thomas Hielscher, Christopher Groth, Alisa Lepper, Xiaoying Hu, Wei Li, Jochen Utikal, Peter Altevogt, Viktor Umansky

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e005551; DOI: 10.1136/jitc-2022-005551
Novel peptide-based vaccine targeting heat shock protein 90 induces effective antitumor immunity in a HER2+ breast cancer murine model
Jinho Kang, Hye-Jin Lee, Jimin Lee, Jinhwa Hong, Yeul Hong Kim, Mary L Disis, Jeong-An Gim, Kyong Hwa Park

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e004702; DOI: 10.1136/jitc-2022-004702
FBW7-mediated ubiquitination and destruction of PD-1 protein primes sensitivity to anti-PD-1 immunotherapy in non-small cell lung cancer
Jiaxin Liu, Lingyun Wei, Nan Hu, Dong Wang, Juan Ni, Sha Zhang, Hongbing Liu, Tangfeng Lv, Jie Yin, Mingxiang Ye, Yong Song

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e005116; DOI: 10.1136/jitc-2022-005116
Tumor-associated macrophage-specific CD155 contributes to M2-phenotype transition, immunosuppression, and tumor progression in colorectal cancer
Xudong Zhu, Rongpu Liang, Tianyun Lan, Dongbing Ding, Shengxin Huang, Jun Shao, Zongheng Zheng, Tufeng Chen, Yong Huang, Jianpei Liu, Janak L Pathak, Hongbo Wei, Bo Wei

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e004219; DOI: 10.1136/jitc-2021-004219
N-cadherin protects oral cancer cells from NK cell killing in the circulation by inducing NK cell functional exhaustion via the KLRG1 receptor
Chao Lou, Kailiu Wu, Jianbo Shi, Zhenlin Dai, Qin Xu

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e005061; DOI: 10.1136/jitc-2022-005061
Targeting two distinct epitopes on human CD73 with a bispecific antibody improves anticancer activity
Odd L Gammelgaard, Mikkel G Terp, Christian Renn, Aran F Labrijn, Oliver Hamaker, Aaraby Y Nielsen, Henriette Vever, Soren WK Hansen, Morten F Gjerstorff, Christa E Müller, Paul WHI Parren, Henrik J Ditzel

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e004554; DOI: 10.1136/jitc-2022-004554

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