Basic Tumor Immunology

Loss of host tissue transglutaminase boosts antitumor T cell immunity by altering STAT1/STAT3 phosphorylation in ovarian cancer
Livia Elena Sima, Siqi Chen, Horacio Cardenas, Guangyuan Zhao, Yinu Wang, Cristina Ivan, Hao Huang, Bin Zhang, Daniela Matei

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002682; DOI: 10.1136/jitc-2021-002682
Macrophage STING signaling promotes NK cell to suppress colorectal cancer liver metastasis via 4-1BBL/4-1BB co-stimulation
Yu Sun, Haoran Hu, Zheng Liu, Jian Xu, Yiyun Gao, Xinyu Zhan, Shun Zhou, Weizhe Zhong, Dongming Wu, Ping Wang, Zhuqing Rao, Lianbao Kong, Haoming Zhou

Journal for ImmunoTherapy of Cancer Mar 2023, 11 (3) e006481; DOI: 10.1136/jitc-2022-006481
Inactivation of interleukin-30 in colon cancer stem cells via CRISPR/Cas9 genome editing inhibits their oncogenicity and improves host survival
Luigi D'Antonio, Cristiano Fieni, Stefania Livia Ciummo, Simone Vespa, Lavinia Lotti, Carlo Sorrentino, Emma Di Carlo

Journal for ImmunoTherapy of Cancer Mar 2023, 11 (3) e006056; DOI: 10.1136/jitc-2022-006056
Pre-existing TGF-β-specific T-cell immunity in patients with pancreatic cancer predicts survival after checkpoint inhibitors combined with radiotherapy
Rasmus Erik Johansson Mortensen, Morten Orebo Holmström, Thomas Landkildehus Lisle, Jane P Hasselby, Gro L Willemoe, Özcan Met, Inge Marie Svane, Julia Johansen, Dorte L Nielsen, Inna M Chen, Mads Hald Andersen

Journal for ImmunoTherapy of Cancer Mar 2023, 11 (3) e006432; DOI: 10.1136/jitc-2022-006432
Identification of HPV16 E1 and E2-specific T cells in the oropharyngeal cancer tumor microenvironment
Christine McInnis, Shilpa Bhatia, Brinda Vijaykumar, Qiaomu Tian, Yanbo Sun, Del Leistritz-Edwards, Charles T Quinn, Ravi Uppaluri, Ann Marie Egloff, Lakshmi Srinivasan, Daniel C Pregibon, Anthony J Coyle, Glenn J Hanna

Journal for ImmunoTherapy of Cancer Mar 2023, 11 (3) e006721; DOI: 10.1136/jitc-2023-006721
ANXA1-derived peptide for targeting PD-L1 degradation inhibits tumor immune evasion in multiple cancers
Zheng-Zheng Yu, Yun-Ya Liu, Wei Zhu, Ding Xiao, Wei Huang, Shan-Shan Lu, Hong Yi, Ting Zeng, Xue-Ping Feng, Li Yuan, Jie-Ya Qiu, Di Wu, Qi Wen, Jian-Hua Zhou, Wei Zhuang, Zhi-Qiang Xiao

Journal for ImmunoTherapy of Cancer Mar 2023, 11 (3) e006345; DOI: 10.1136/jitc-2022-006345
Invasive margin tissue-resident macrophages of high CD163 expression impede responses to T cell-based immunotherapy
Marit J van Elsas, Camilla Labrie, Anders Etzerodt, Pornpimol Charoentong, Jordi J C van Stigt Thans, Thorbald Van Hall, Sjoerd H van der Burg

Journal for ImmunoTherapy of Cancer Mar 2023, 11 (3) e006433; DOI: 10.1136/jitc-2022-006433
Local and systemic immune profiles of human pancreatic ductal adenocarcinoma revealed by single-cell mass cytometry
Thomas P Brouwer, Natasja L de Vries, Tamim Abdelaal, Ricki T Krog, Zheng Li, Dina Ruano, Arantza Fariña, Boudewijn P F Lelieveldt, Hans Morreau, Bert A Bonsing, Alexander L Vahrmeijer, Frits Koning, Noel F C C de Miranda

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004638; DOI: 10.1136/jitc-2022-004638
Necroptosis-driving genes RIPK1, RIPK3 and MLKL-p are associated with intratumoral CD3⁺ and CD8⁺ T cell density and predict prognosis in hepatocellular carcinoma
Lorenzo Nicolè, Tiziana Sanavia, Rocco Cappellesso, Valeria Maffeis, Jun Akiba, Akihiko Kawahara, Yoshiki Naito, Claudia Maria Radu, Paolo Simioni, Davide Serafin, Giuliana Cortese, Maria Guido, Giacomo Zanus, Hirohisa Yano, Ambrogio Fassina

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e004031; DOI: 10.1136/jitc-2021-004031
Inhibition of stearoyl-CoA desaturase 1 (SCD1) enhances the antitumor T cell response through regulating β-catenin signaling in cancer cells and ER stress in T cells and synergizes with anti-PD-1 antibody
Yuki Katoh, Tomonori Yaguchi, Akiko Kubo, Takashi Iwata, Kenji Morii, Daiki Kato, Shigeki Ohta, Ryosuke Satomi, Yasuhiro Yamamoto, Yoshitaka Oyamada, Kota Ouchi, Shin Takahashi, Chikashi Ishioka, Ryo Matoba, Makoto Suematsu, Yutaka Kawakami

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004616; DOI: 10.1136/jitc-2022-004616

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