Basic Tumor Immunology

Dendritic cell-mediated cross presentation of tumor-derived peptides is biased against plasma membrane proteins
Tim B Fessenden, Lauren E Stopfer, Fiona Chatterjee, Julian Zulueta, Josh Mesfin, Therese Cordero Dumit, Irene Reijers, Esmee P Hoefsmit, Christian Blank, Forest White, Stefani Spranger

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004159; DOI: 10.1136/jitc-2021-004159
CD40×HER2 bispecific antibody overcomes the CCL2-induced trastuzumab resistance in HER2-positive gastric cancer
Weilin Sun, Xi Wang, Daohan Wang, Li Lu, Hai Lin, Zhaoxiong Zhang, Yangpu Jia, Xinyang Nie, Tong Liu, Weihua Fu

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e005063; DOI: 10.1136/jitc-2022-005063
Toll-like receptor 8 agonists improve NK-cell function primarily targeting CD56^brightCD16⁻ subset
Irene Veneziani, Claudia Alicata, Andrea Pelosi, Nadine Landolina, Biancamaria Ricci, Valentina D'Oria, Anna Fagotti, Giovanni Scambia, Lorenzo Moretta, Enrico Maggi

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003385; DOI: 10.1136/jitc-2021-003385
ELK3 modulates the antitumor efficacy of natural killer cells against triple negative breast cancer by regulating mitochondrial dynamics
Joo Dong Park, Kwang-Soo Kim, Seung Hee Choi, Gae Hoon Jo, Jin-Ho Choi, Si-Won Park, Eun-Su Ko, Minwook Lee, Dae-Keum Lee, Hye Jung Jang, Sohyun Hwang, Hae-Yun Jung, Kyung-Soon Park

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004825; DOI: 10.1136/jitc-2022-004825
STAT3 inhibitor Napabucasin abrogates MDSC immunosuppressive capacity and prolongs survival of melanoma-bearing mice
Rebekka Bitsch, Annina Kurzay, Feyza Özbay Kurt, Carolina De La Torre, Samantha Lasser, Alisa Lepper, Alina Siebenmorgen, Verena Müller, Peter Altevogt, Jochen Utikal, Viktor Umansky

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e004384; DOI: 10.1136/jitc-2021-004384
Intrahepatic CD69⁺Vδ1 T cells re-circulate in the blood of patients with metastatic colorectal cancer and limit tumor progression
Elena Bruni, Matteo Maria Cimino, Matteo Donadon, Roberta Carriero, Sara Terzoli, Rocco Piazza, Sarina Ravens, Immo Prinz, Valentina Cazzetta, Paolo Marzano, Paolo Kunderfranco, Clelia Peano, Cristiana Soldani, Barbara Franceschini, Federico Simone Colombo, Cecilia Garlanda, Alberto Mantovani, Guido Torzilli, Joanna Mikulak, Domenico Mavilio

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004579; DOI: 10.1136/jitc-2022-004579
Chemical augmentation of mitochondrial electron transport chains tunes T cell activation threshold in tumors
Yosuke Dotsu, Daisuke Muraoka, Naohisa Ogo, Yudai Sonoda, Kiyoshi Yasui, Hiroyuki Yamaguchi, Hideo Yagita, Hiroshi Mukae, Akira Asai, Hiroaki Ikeda

Journal for ImmunoTherapy of Cancer Feb 2022, 10 (2) e003958; DOI: 10.1136/jitc-2021-003958
TGFβ receptor inhibition unleashes interferon-β production by tumor-associated macrophages and enhances radiotherapy efficacy
Pauline Hamon, Marine Gerbé De Thoré, Marion Classe, Nicolas Signolle, Winchygn Liu, Olivia Bawa, Lydia Meziani, Céline Clémenson, Fabien Milliat, Eric Deutsch, Michele Mondini

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e003519; DOI: 10.1136/jitc-2021-003519
Single-cell transcriptomics reveals a low CD8⁺ T cell infiltrating state mediated by fibroblasts in recurrent renal cell carcinoma
Yu-Lu Peng, Long-Bin Xiong, Zhao-Hui Zhou, Kang Ning, Zhen Li, Ze-Shen Wu, Min-Hua Deng, Wen-Su Wei, Ning Wang, Xiang-Peng Zou, Zhi-Song He, Ji-Wei Huang, Jun-Hang Luo, Jian-Ye Liu, Nan Jia, Yun Cao, Hui Han, Sheng-Jie Guo, Pei Dong, Chun-Ping Yu, Fang-Jian Zhou, Zhi-Ling Zhang

Journal for ImmunoTherapy of Cancer Feb 2022, 10 (2) e004206; DOI: 10.1136/jitc-2021-004206
Unique characteristics of tertiary lymphoid structures in kidney clear cell carcinoma: prognostic outcome and comparison with bladder cancer
Tsukasa Masuda, Nobuyuki Tanaka, Kimiharu Takamatsu, Kyohei Hakozaki, Ryohei Takahashi, Tadatsugu Anno, Ryohei Kufukihara, Kazunori Shojo, Shuji Mikami, Toshiaki Shinojima, Kazuhiro Kakimi, Tatsuhiko Tsunoda, Eriko Aimono, Hiroshi Nishihara, Ryuichi Mizuno, Mototsugu Oya

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e003883; DOI: 10.1136/jitc-2021-003883

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