Basic Tumor Immunology

Tumor microenvironment shows an immunological abscopal effect in patients with NSCLC treated with pembrolizumab-radiotherapy combination
Lieke L van der Woude, Mark A J Gorris, Inge M N Wortel, Jeroen H A Creemers, Kiek Verrijp, Kim Monkhorst, Katrien Grünberg, Michel M van den Heuvel, Johannes Textor, Carl G Figdor, Berber Piet, Willemijn S M E Theelen, I Jolanda M de Vries

Journal for ImmunoTherapy of Cancer Oct 2022, 10 (10) e005248; DOI: 10.1136/jitc-2022-005248
Immunosuppressive lncRNA LINC00624 promotes tumor progression and therapy resistance through ADAR1 stabilization
Qi Zhang, Bingqiu Xiu, Liyi Zhang, Ming Chen, Weiru Chi, Lun Li, Rong Guo, Jingyan Xue, Benlong Yang, Xiaoyan Huang, Zhi-Ming Shao, Shenglin Huang, Yayun Chi, Jiong Wu

Journal for ImmunoTherapy of Cancer Oct 2022, 10 (10) e004666; DOI: 10.1136/jitc-2022-004666
Tumor MHC class I expression alters cancer-associated myelopoiesis driven by host NK cells
Shi Yong Neo, Xu Jing, Le Tong, Dongmei Tong, Juan Gao, Ziqing Chen, Mireia Cruz De Los Santos, Nutsa Burduli, Sabrina De Souza Ferreira, Arnika Kathleen Wagner, Evren Alici, Charlotte Rolny, Yihai Cao, Andreas Lundqvist

Journal for ImmunoTherapy of Cancer Oct 2022, 10 (10) e005308; DOI: 10.1136/jitc-2022-005308
Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation
Guoliang Deng, Lisha Zhou, Binglin Wang, Xiaofan Sun, Qinchang Zhang, Hongqi Chen, Ning Wan, Hui Ye, Xiaoqi Wu, Dongdong Sun, Yang Sun, Haibo Cheng

Journal for ImmunoTherapy of Cancer Oct 2022, 10 (10) e004874; DOI: 10.1136/jitc-2022-004874
Arginase-2-specific cytotoxic T cells specifically recognize functional regulatory T cells
Stine Emilie Weis-Banke, Thomas Landkildehus Lisle, Maria Perez-Penco, Aimilia Schina, Mie Linder Hübbe, Majken Siersbæk, Morten Orebo Holmström, Mia Aaboe Jørgensen, Inge Marie Svane, Özcan Met, Niels Ødum, Daniel Hargbøl Madsen, Marco Donia, Lars Grøntved, Mads Hald Andersen

Journal for ImmunoTherapy of Cancer Oct 2022, 10 (10) e005326; DOI: 10.1136/jitc-2022-005326
Tumor cell-intrinsic SETD2 inactivation sensitizes cancer cells to immune checkpoint blockade through the NR2F1-STAT1 pathway
Xufen Zheng, Yuxiang Luo, Yangjie Xiong, Xiaoxiao Liu, Chunling Zeng, Xiaojing Lu, Xiaofang Wang, Yumei Cheng, Simin Wang, Haoqi Lan, Kai Wang, Zhonghui Weng, Wenbo Bi, Xinxin Gan, Xiaona Jia, Linhui Wang, Yuexiang Wang

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e007678; DOI: 10.1136/jitc-2023-007678
Caspase-9 inhibition triggers Hsp90-based chemotherapy-mediated tumor intrinsic innate sensing and enhances antitumor immunity
Jingyang Li, Xiaoyu Han, Mayu Sun, Weida Li, Guanghuan Yang, Huiyi Chen, Bao Guo, Jingquan Li, Xiaoguang Li, Hui Wang

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e007625; DOI: 10.1136/jitc-2023-007625
Fibrinogen-like protein 2 promotes tumor immune suppression by regulating cholesterol metabolism in myeloid-derived suppressor cells
Lei Wu, Xudong Liu, Juan Lei, Nan Zhang, Huakan Zhao, Jiangang Zhang, Huan Deng, Yongsheng Li

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e008081; DOI: 10.1136/jitc-2023-008081
Dynamical modeling of proliferative-invasive plasticity and IFNγ signaling in melanoma reveals mechanisms of PD-L1 expression heterogeneity
Seemadri Subhadarshini, Sarthak Sahoo, Shibjyoti Debnath, Jason A Somarelli, Mohit Kumar Jolly

Journal for ImmunoTherapy of Cancer Sep 2023, 11 (9) e006766; DOI: 10.1136/jitc-2023-006766
ATM inhibition augments type I interferon response and antitumor T-cell immunity when combined with radiation therapy in murine tumor models
Won Jong Jin, Luke M Zangl, Meredith Hyun, Elian Massoud, Kaleb Schroeder, Roxana A Alexandridis, Zachary S Morris

Journal for ImmunoTherapy of Cancer Sep 2023, 11 (9) e007474; DOI: 10.1136/jitc-2023-007474

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