Basic Tumor Immunology

Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation
Guoliang Deng, Lisha Zhou, Binglin Wang, Xiaofan Sun, Qinchang Zhang, Hongqi Chen, Ning Wan, Hui Ye, Xiaoqi Wu, Dongdong Sun, Yang Sun, Haibo Cheng

Journal for ImmunoTherapy of Cancer Oct 2022, 10 (10) e004874; DOI: 10.1136/jitc-2022-004874
Arginase-2-specific cytotoxic T cells specifically recognize functional regulatory T cells
Stine Emilie Weis-Banke, Thomas Landkildehus Lisle, Maria Perez-Penco, Aimilia Schina, Mie Linder Hübbe, Majken Siersbæk, Morten Orebo Holmström, Mia Aaboe Jørgensen, Inge Marie Svane, Özcan Met, Niels Ødum, Daniel Hargbøl Madsen, Marco Donia, Lars Grøntved, Mads Hald Andersen

Journal for ImmunoTherapy of Cancer Oct 2022, 10 (10) e005326; DOI: 10.1136/jitc-2022-005326
Blockades of effector T cell senescence and exhaustion synergistically enhance antitumor immunity and immunotherapy
Xia Liu, Fusheng Si, David Bagley, Feiya Ma, Yuanqin Zhang, Yan Tao, Emily Shaw, Guangyong Peng

Journal for ImmunoTherapy of Cancer Oct 2022, 10 (10) e005020; DOI: 10.1136/jitc-2022-005020
Mast cell-T cell axis alters development of colitis-dependent and colitis-independent colorectal tumours: potential for therapeutically targeting via mast cell inhibition
Juliana Y Sakita, Jefferson Elias-Oliveira, Daniela Carlos, Emerson de Souza Santos, Luciana Yamamoto Almeida, Tathiane M Malta, Mariângela O Brunaldi, Sergio Albuquerque, Cleide Lúcia Araújo Silva, Marcus V Andrade, Vania L D Bonato, Sergio Britto Garcia, Fernando Queiroz Cunha, Guilherme Cesar Martelossi Cebinelli, Ronaldo B Martins, Jason Matthews, Leandro Colli, Francis L Martin, Sergio A Uyemura, Vinicius Kannen

Journal for ImmunoTherapy of Cancer Oct 2022, 10 (10) e004653; DOI: 10.1136/jitc-2022-004653
Tumor microenvironment shows an immunological abscopal effect in patients with NSCLC treated with pembrolizumab-radiotherapy combination
Lieke L van der Woude, Mark A J Gorris, Inge M N Wortel, Jeroen H A Creemers, Kiek Verrijp, Kim Monkhorst, Katrien Grünberg, Michel M van den Heuvel, Johannes Textor, Carl G Figdor, Berber Piet, Willemijn S M E Theelen, I Jolanda M de Vries

Journal for ImmunoTherapy of Cancer Oct 2022, 10 (10) e005248; DOI: 10.1136/jitc-2022-005248
Tumor cell-intrinsic SETD2 inactivation sensitizes cancer cells to immune checkpoint blockade through the NR2F1-STAT1 pathway
Xufen Zheng, Yuxiang Luo, Yangjie Xiong, Xiaoxiao Liu, Chunling Zeng, Xiaojing Lu, Xiaofang Wang, Yumei Cheng, Simin Wang, Haoqi Lan, Kai Wang, Zhonghui Weng, Wenbo Bi, Xinxin Gan, Xiaona Jia, Linhui Wang, Yuexiang Wang

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e007678; DOI: 10.1136/jitc-2023-007678
Caspase-9 inhibition triggers Hsp90-based chemotherapy-mediated tumor intrinsic innate sensing and enhances antitumor immunity
Jingyang Li, Xiaoyu Han, Mayu Sun, Weida Li, Guanghuan Yang, Huiyi Chen, Bao Guo, Jingquan Li, Xiaoguang Li, Hui Wang

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e007625; DOI: 10.1136/jitc-2023-007625
Fibrinogen-like protein 2 promotes tumor immune suppression by regulating cholesterol metabolism in myeloid-derived suppressor cells
Lei Wu, Xudong Liu, Juan Lei, Nan Zhang, Huakan Zhao, Jiangang Zhang, Huan Deng, Yongsheng Li

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e008081; DOI: 10.1136/jitc-2023-008081
ATM inhibition augments type I interferon response and antitumor T-cell immunity when combined with radiation therapy in murine tumor models
Won Jong Jin, Luke M Zangl, Meredith Hyun, Elian Massoud, Kaleb Schroeder, Roxana A Alexandridis, Zachary S Morris

Journal for ImmunoTherapy of Cancer Sep 2023, 11 (9) e007474; DOI: 10.1136/jitc-2023-007474
Polymorphonuclear myeloid-derived suppressor cells and phosphatidylinositol-3 kinase gamma are critical to tobacco-mimicking oral carcinogenesis in mice
Khoa A Nguyen, Lisa N DePledge, Li Bian, Yao Ke, Von Samedi, Amber A Berning, Philip Owens, Xiao-Jing Wang, Christian D Young

Journal for ImmunoTherapy of Cancer Sep 2023, 11 (9) e007110; DOI: 10.1136/jitc-2023-007110

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