Basic Tumor Immunology

Inhibition of stearoyl-CoA desaturase 1 (SCD1) enhances the antitumor T cell response through regulating β-catenin signaling in cancer cells and ER stress in T cells and synergizes with anti-PD-1 antibody
Yuki Katoh, Tomonori Yaguchi, Akiko Kubo, Takashi Iwata, Kenji Morii, Daiki Kato, Shigeki Ohta, Ryosuke Satomi, Yasuhiro Yamamoto, Yoshitaka Oyamada, Kota Ouchi, Shin Takahashi, Chikashi Ishioka, Ryo Matoba, Makoto Suematsu, Yutaka Kawakami

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004616; DOI: 10.1136/jitc-2022-004616
Necroptosis-driving genes RIPK1, RIPK3 and MLKL-p are associated with intratumoral CD3⁺ and CD8⁺ T cell density and predict prognosis in hepatocellular carcinoma
Lorenzo Nicolè, Tiziana Sanavia, Rocco Cappellesso, Valeria Maffeis, Jun Akiba, Akihiko Kawahara, Yoshiki Naito, Claudia Maria Radu, Paolo Simioni, Davide Serafin, Giuliana Cortese, Maria Guido, Giacomo Zanus, Hirohisa Yano, Ambrogio Fassina

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e004031; DOI: 10.1136/jitc-2021-004031
Exosomal CD73 from serum of patients with melanoma suppresses lymphocyte functions and is associated with therapy resistance to anti-PD-1 agents
Roberta Turiello, Mariaelena Capone, Elva Morretta, Maria Chiara Monti, Gabriele Madonna, Rosa Azzaro, Pasquale Del Gaudio, Ester Simeone, Antonio Sorrentino, Paolo A Ascierto, Silvana Morello

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e004043; DOI: 10.1136/jitc-2021-004043
Dendritic cell-mediated cross presentation of tumor-derived peptides is biased against plasma membrane proteins
Tim B Fessenden, Lauren E Stopfer, Fiona Chatterjee, Julian Zulueta, Josh Mesfin, Therese Cordero Dumit, Irene Reijers, Esmee P Hoefsmit, Christian Blank, Forest White, Stefani Spranger

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004159; DOI: 10.1136/jitc-2021-004159
CD40×HER2 bispecific antibody overcomes the CCL2-induced trastuzumab resistance in HER2-positive gastric cancer
Weilin Sun, Xi Wang, Daohan Wang, Li Lu, Hai Lin, Zhaoxiong Zhang, Yangpu Jia, Xinyang Nie, Tong Liu, Weihua Fu

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e005063; DOI: 10.1136/jitc-2022-005063
Toll-like receptor 8 agonists improve NK-cell function primarily targeting CD56^brightCD16⁻ subset
Irene Veneziani, Claudia Alicata, Andrea Pelosi, Nadine Landolina, Biancamaria Ricci, Valentina D'Oria, Anna Fagotti, Giovanni Scambia, Lorenzo Moretta, Enrico Maggi

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003385; DOI: 10.1136/jitc-2021-003385
ELK3 modulates the antitumor efficacy of natural killer cells against triple negative breast cancer by regulating mitochondrial dynamics
Joo Dong Park, Kwang-Soo Kim, Seung Hee Choi, Gae Hoon Jo, Jin-Ho Choi, Si-Won Park, Eun-Su Ko, Minwook Lee, Dae-Keum Lee, Hye Jung Jang, Sohyun Hwang, Hae-Yun Jung, Kyung-Soon Park

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004825; DOI: 10.1136/jitc-2022-004825
TIM-3 blockade enhances IL-12-dependent antitumor immunity by promoting CD8⁺ T cell and XCR1⁺ dendritic cell spatial co-localization
Alycia Gardner, Álvaro de Mingo Pulido, Kay Hänggi, Sarah Bazargan, Alexis Onimus, Agnieszka Kasprzak, Jose R Conejo-Garcia, Katarzyna A Rejniak, Brian Ruffell

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003571; DOI: 10.1136/jitc-2021-003571
G6PD functions as a metabolic checkpoint to regulate granzyme B expression in tumor-specific cytotoxic T lymphocytes
Chunwan Lu, Dafeng Yang, John D Klement, Yolonda L Colson, Nicholas H Oberlies, Cedric J Pearce, Aaron H Colby, Mark W Grinstaff, Han-Fei Ding, Huidong Shi, Kebin Liu

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003543; DOI: 10.1136/jitc-2021-003543
Fc-null anti-PD-1 monoclonal antibodies deliver optimal checkpoint blockade in diverse immune environments
Julia Moreno-Vicente, Jane E Willoughby, Martin C Taylor, Steven G Booth, Vikki L English, Emily L Williams, Christine A Penfold, C Ian Mockridge, Tatyana Inzhelevskaya, Jinny Kim, H T Claude Chan, Mark S Cragg, Juliet C Gray, Stephen A Beers

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003735; DOI: 10.1136/jitc-2021-003735

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