- Glial Fibrillary Acidic Protein Astrocytopathy: Review of Pathogenesis, Imaging Features, and Radiographic Mimics
Glial fibrillary acidic protein (GFAP) astrocytopathy is a CNS autoimmune inflammatory disorder characterized by specific antibodies targeting the intracellular filament protein in mature astrocytes. Neuroimaging findings include linear perivascular enhancement in the white matter extending in a radial pattern, periependymal enhancement, longitudinally extensive cord signal changes, intramedullary enhancement, optic neuritis, and papillitis.
- Radiologic Classification of Hippocampal Sclerosis in Epilepsy
This review explores how the International League Against Epilepsy (ILAE) subtypes of hippocampal sclerosis correlate with MRI findings. Hippocampal anatomy is reviewed in detail. The pathophysiology of hippocampal sclerosis is discussed. A radiologic classification scheme is proposed that aligns with the ILAE pathology classification, aiming to improve clinical communication and decision-making.
- Multiparametric Characterization and Spatial Distribution of Different MS Lesion Phenotypes
Lesion phenotype (ie, different levels of axonal and myelin loss and spatial distribution) was characterized using quantitative susceptibility mapping, susceptibility-weighted imaging, T1-relaxometry, myelin mapping, and diffusion MRI. A more severe disease course was observed in hyperintense and paramagnetic rim lesions in the periventricular white matter.
- Comparison of a Whole-Brain Contrast-Enhanced 3D TSE T1WI versus Orbits Contrast-Enhanced 2D Coronal T1WI at 3T MRI for the Detection of Optic Nerve Enhancement in Patients with Acute Loss of Visual Acuity
This retrospective, single-center study of 1023 patients presenting with acute loss of vision compared orbits contrast-enhanced 2D coronal T1WI with a whole-brain contrast-enhanced 3D TSE T1WI at 3T for the detection of optic nerve enhancement. The latter (WBCE-3D T1WI) demonstrated higher sensitivity and specificity in diagnosing optic neuritis, particularly in cases involving the canalicular segments.
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