- Diffusion-Weighted Imaging Reveals Impaired Glymphatic Clearance in Idiopathic Intracranial Hypertension
The diffusivity along the cerebral perivascular spaces (DTI-ALPS technique) and lateral association and projection fibers in patients with IIH were compared with normal controls. Using the degree of diffusivity as a surrogate for glymphatic function, IIH patients were shown to have a significantly lower glymphatic clearance compared with controls (P=.005), with a significant association between declining glymphatic clearance and increasing Frisen papilledema grade (P=.046).
- Newly Recognized Genetic Tumor Syndromes of the CNS in the 5th WHO Classification: Imaging Overview with Genetic Updates
In this review of the new 5th edition of the WHO classification, the authors focus on imaging and genetic characteristics of 8 new syndromes: Elongator protein complex-medulloblastoma syndrome, BRCA1-associated protein 1 tumor-predisposition syndrome, DICER1 syndrome, familial paraganglioma syndrome, melanoma-astrocytoma syndrome, Carney complex, Fanconi anemia, and familial retinoblastoma.
- Clinical and Imaging Findings in Children with Myelin Oligodendrocyte Glycoprotein Antibody Associated Disease (MOGAD): From Presentation to Relapse
This study characterizes the CNS imaging manifestations of pediatric MOGAD. The authors also identify the clinical and imaging variables associated with relapse. There is an age-dependent imaging phenotype at presentation and first relapse, and older age at presentation is associated with shorter time to relapse.
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