Predicting Ten-Year Clinical Outcomes in Multiple Sclerosis with Radiomics-Based Machine Learning Models

Mario Tranfa; Maria Petracca; Renato Cuocolo; Lorenzo Ugga; Vincenzo Brescia Morra; Antonio Carotenuto; Andrea Elefante; Fabrizia Falco; Roberta Lanzillo; Marcello Moccia; Alessandra Scaravilli; Arturo Brunetti; Sirio Cocozza; Mario Quarantelli; Giuseppe Pontillo

doi:10.3174/ajnr.A8912

Research ArticleORIGINAL RESEARCH

Predicting Ten-Year Clinical Outcomes in Multiple Sclerosis with Radiomics-Based Machine Learning Models

Mario Tranfa, Maria Petracca, Renato Cuocolo, Lorenzo Ugga, Vincenzo Brescia Morra, Antonio Carotenuto, Andrea Elefante, Fabrizia Falco, Roberta Lanzillo, Marcello Moccia, Alessandra Scaravilli, Arturo Brunetti, Sirio Cocozza, Mario Quarantelli and Giuseppe Pontillo

American Journal of Neuroradiology July 2025, ajnr.A8912; DOI: https://doi.org/10.3174/ajnr.A8912

Mario Tranfa

1 Department of Advanced Biomedical Sciences, University “Federico II”, Naples, Italy

2 Department of Radiology and Nuclear Medicine, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

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Maria Petracca

3 Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy

MD, PhD

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Renato Cuocolo

4 Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Italy

MD, PhD

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Lorenzo Ugga

1 Department of Advanced Biomedical Sciences, University “Federico II”, Naples, Italy

MD, PhD

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Vincenzo Brescia Morra

5 Department of Neurosciences and Reproductive and Odontostomatological Sciences, University of Naples “Federico II”, Naples, Italy

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Antonio Carotenuto

5 Department of Neurosciences and Reproductive and Odontostomatological Sciences, University of Naples “Federico II”, Naples, Italy

MD, PhD

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Andrea Elefante

1 Department of Advanced Biomedical Sciences, University “Federico II”, Naples, Italy

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Fabrizia Falco

5 Department of Neurosciences and Reproductive and Odontostomatological Sciences, University of Naples “Federico II”, Naples, Italy

PhD

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Roberta Lanzillo

5 Department of Neurosciences and Reproductive and Odontostomatological Sciences, University of Naples “Federico II”, Naples, Italy

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Marcello Moccia

6 Multiple Sclerosis Unit, Policlinico Federico II University Hospital, Via Sergio Pansini 5, 80131, Naples, Italy

7 Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, Naples, Italy

MD, PhD

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Alessandra Scaravilli

1 Department of Advanced Biomedical Sciences, University “Federico II”, Naples, Italy

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Arturo Brunetti

1 Department of Advanced Biomedical Sciences, University “Federico II”, Naples, Italy

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Sirio Cocozza

1 Department of Advanced Biomedical Sciences, University “Federico II”, Naples, Italy

MD, PhD

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Mario Quarantelli

8 Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy

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Giuseppe Pontillo

1 Department of Advanced Biomedical Sciences, University “Federico II”, Naples, Italy

2 Department of Radiology and Nuclear Medicine, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

9 Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom

10 Department of Anatomy and Neurosciences, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

MD, PhD

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Predicting Ten-Year Clinical Outcomes in Multiple Sclerosis with Radiomics-Based Machine Learning Models

American Journal of Neuroradiology Jul 2025, ajnr.A8912; DOI: 10.3174/ajnr.A8912

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Accepted Manuscript

Predicting Ten-Year Clinical Outcomes in Multiple Sclerosis with Radiomics-Based Machine Learning Models

American Journal of Neuroradiology Jul 2025, ajnr.A8912; DOI: 10.3174/ajnr.A8912

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