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Research ArticleORIGINAL RESEARCH

DTI-Derived Evaluation of Glymphatic System Function in Veterans with Chronic Multisymptom Illness

Yu Zhang, Matthew S. Moore, Yashar Rahimpour, J. David Clark, Peter J. Bayley, J. Wesson Ashford and Ansgar J. Furst
American Journal of Neuroradiology June 2025, ajnr.A8901; DOI: https://doi.org/10.3174/ajnr.A8901
Yu Zhang
From the War Related Illness & Injury Study Center (WRIISC) (Y.Z., M.S.M., Y.R., P.J.B., J.W.A., A.J.F), Pain Clinic (J.D.C.), and Polytrauma System of Care (A.J.F.), VA Palo Alto Health Care System, Palo Alto, California, United States; Department of Psychiatry and Behavioral Sciences (M.S.M., Y.R., P.J.B., J.W.A., A.J.F.), Department of Anesthesiology, Perioperative and Pain Medicine (J.D.C.), and Department of Neurology and Neurological Sciences (A.J.F.), Stanford University School of Medicine, Stanford, California, United States.
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Matthew S. Moore
From the War Related Illness & Injury Study Center (WRIISC) (Y.Z., M.S.M., Y.R., P.J.B., J.W.A., A.J.F), Pain Clinic (J.D.C.), and Polytrauma System of Care (A.J.F.), VA Palo Alto Health Care System, Palo Alto, California, United States; Department of Psychiatry and Behavioral Sciences (M.S.M., Y.R., P.J.B., J.W.A., A.J.F.), Department of Anesthesiology, Perioperative and Pain Medicine (J.D.C.), and Department of Neurology and Neurological Sciences (A.J.F.), Stanford University School of Medicine, Stanford, California, United States.
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Yashar Rahimpour
From the War Related Illness & Injury Study Center (WRIISC) (Y.Z., M.S.M., Y.R., P.J.B., J.W.A., A.J.F), Pain Clinic (J.D.C.), and Polytrauma System of Care (A.J.F.), VA Palo Alto Health Care System, Palo Alto, California, United States; Department of Psychiatry and Behavioral Sciences (M.S.M., Y.R., P.J.B., J.W.A., A.J.F.), Department of Anesthesiology, Perioperative and Pain Medicine (J.D.C.), and Department of Neurology and Neurological Sciences (A.J.F.), Stanford University School of Medicine, Stanford, California, United States.
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J. David Clark
From the War Related Illness & Injury Study Center (WRIISC) (Y.Z., M.S.M., Y.R., P.J.B., J.W.A., A.J.F), Pain Clinic (J.D.C.), and Polytrauma System of Care (A.J.F.), VA Palo Alto Health Care System, Palo Alto, California, United States; Department of Psychiatry and Behavioral Sciences (M.S.M., Y.R., P.J.B., J.W.A., A.J.F.), Department of Anesthesiology, Perioperative and Pain Medicine (J.D.C.), and Department of Neurology and Neurological Sciences (A.J.F.), Stanford University School of Medicine, Stanford, California, United States.
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Peter J. Bayley
From the War Related Illness & Injury Study Center (WRIISC) (Y.Z., M.S.M., Y.R., P.J.B., J.W.A., A.J.F), Pain Clinic (J.D.C.), and Polytrauma System of Care (A.J.F.), VA Palo Alto Health Care System, Palo Alto, California, United States; Department of Psychiatry and Behavioral Sciences (M.S.M., Y.R., P.J.B., J.W.A., A.J.F.), Department of Anesthesiology, Perioperative and Pain Medicine (J.D.C.), and Department of Neurology and Neurological Sciences (A.J.F.), Stanford University School of Medicine, Stanford, California, United States.
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J. Wesson Ashford
From the War Related Illness & Injury Study Center (WRIISC) (Y.Z., M.S.M., Y.R., P.J.B., J.W.A., A.J.F), Pain Clinic (J.D.C.), and Polytrauma System of Care (A.J.F.), VA Palo Alto Health Care System, Palo Alto, California, United States; Department of Psychiatry and Behavioral Sciences (M.S.M., Y.R., P.J.B., J.W.A., A.J.F.), Department of Anesthesiology, Perioperative and Pain Medicine (J.D.C.), and Department of Neurology and Neurological Sciences (A.J.F.), Stanford University School of Medicine, Stanford, California, United States.
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Ansgar J. Furst
From the War Related Illness & Injury Study Center (WRIISC) (Y.Z., M.S.M., Y.R., P.J.B., J.W.A., A.J.F), Pain Clinic (J.D.C.), and Polytrauma System of Care (A.J.F.), VA Palo Alto Health Care System, Palo Alto, California, United States; Department of Psychiatry and Behavioral Sciences (M.S.M., Y.R., P.J.B., J.W.A., A.J.F.), Department of Anesthesiology, Perioperative and Pain Medicine (J.D.C.), and Department of Neurology and Neurological Sciences (A.J.F.), Stanford University School of Medicine, Stanford, California, United States.
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Article Information

ajnr.A8901
DOI 
https://doi.org/10.3174/ajnr.A8901
PubMed 
40579044

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Published online June 27, 2025.

Copyright & Usage 
© 2025 by American Journal of Neuroradiology

Author Information

  1. Yu Zhang,
  2. Matthew S. Moore,
  3. Yashar Rahimpour,
  4. J. David Clark,
  5. Peter J. Bayley,
  6. J. Wesson Ashford and
  7. Ansgar J. Furst
  1. From the War Related Illness & Injury Study Center (WRIISC) (Y.Z., M.S.M., Y.R., P.J.B., J.W.A., A.J.F), Pain Clinic (J.D.C.), and Polytrauma System of Care (A.J.F.), VA Palo Alto Health Care System, Palo Alto, California, United States; Department of Psychiatry and Behavioral Sciences (M.S.M., Y.R., P.J.B., J.W.A., A.J.F.), Department of Anesthesiology, Perioperative and Pain Medicine (J.D.C.), and Department of Neurology and Neurological Sciences (A.J.F.), Stanford University School of Medicine, Stanford, California, United States.
  1. Corresponding author: Yu Zhang, MD, PhD. War Related Illness and Injury Study Center (WRIISC). VA Palo Alto Health Care System. 3801 Miranda Ave, Mail code 151Y. Palo Alto, CA 94304-1290, United States. E-mails: Yu.Zhang{at}va.gov; yuzhangucsfedu{at}gmail.com.

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Cite this article
Accepted Manuscript
Yu Zhang, Matthew S. Moore, Yashar Rahimpour, J. David Clark, Peter J. Bayley, J. Wesson Ashford, Ansgar J. Furst
DTI-Derived Evaluation of Glymphatic System Function in Veterans with Chronic Multisymptom Illness
American Journal of Neuroradiology Jun 2025, ajnr.A8901; DOI: 10.3174/ajnr.A8901

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Accepted Manuscript
DTI-Derived Evaluation of Glymphatic System Function in Veterans with Chronic Multisymptom Illness
Yu Zhang, Matthew S. Moore, Yashar Rahimpour, J. David Clark, Peter J. Bayley, J. Wesson Ashford, Ansgar J. Furst
American Journal of Neuroradiology Jun 2025, ajnr.A8901; DOI: 10.3174/ajnr.A8901
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