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Research ArticleORIGINAL RESEARCH

Deep Learning-Based Prediction of PET Amyloid Status Using MRI

Donghoon Kim, Jon André Ottesen, Ashwin Kumar, Brandon C. Ho, Elsa Bismuth, Christina B. Young, Elizabeth Mormino, Greg Zaharchuk and for the Alzheimer’s Disease Neuroimaging Initiative
American Journal of Neuroradiology June 2025, ajnr.A8899; DOI: https://doi.org/10.3174/ajnr.A8899
Donghoon Kim
From the Department of Radiology (D.K., J.A.O., A.K., B.C.H., E.B.,), and the Department of Neurology and Neurological Sciences (C.B.Y., E.M.), Stanford University, Stanford, California, USA, and Computational Radiology and Artificial Intelligence (CRAI) Research Group (J.A.O), Oslo University Hospital, Oslo, Norway.
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Jon André Ottesen
From the Department of Radiology (D.K., J.A.O., A.K., B.C.H., E.B.,), and the Department of Neurology and Neurological Sciences (C.B.Y., E.M.), Stanford University, Stanford, California, USA, and Computational Radiology and Artificial Intelligence (CRAI) Research Group (J.A.O), Oslo University Hospital, Oslo, Norway.
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Ashwin Kumar
From the Department of Radiology (D.K., J.A.O., A.K., B.C.H., E.B.,), and the Department of Neurology and Neurological Sciences (C.B.Y., E.M.), Stanford University, Stanford, California, USA, and Computational Radiology and Artificial Intelligence (CRAI) Research Group (J.A.O), Oslo University Hospital, Oslo, Norway.
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Brandon C. Ho
From the Department of Radiology (D.K., J.A.O., A.K., B.C.H., E.B.,), and the Department of Neurology and Neurological Sciences (C.B.Y., E.M.), Stanford University, Stanford, California, USA, and Computational Radiology and Artificial Intelligence (CRAI) Research Group (J.A.O), Oslo University Hospital, Oslo, Norway.
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Elsa Bismuth
From the Department of Radiology (D.K., J.A.O., A.K., B.C.H., E.B.,), and the Department of Neurology and Neurological Sciences (C.B.Y., E.M.), Stanford University, Stanford, California, USA, and Computational Radiology and Artificial Intelligence (CRAI) Research Group (J.A.O), Oslo University Hospital, Oslo, Norway.
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Christina B. Young
From the Department of Radiology (D.K., J.A.O., A.K., B.C.H., E.B.,), and the Department of Neurology and Neurological Sciences (C.B.Y., E.M.), Stanford University, Stanford, California, USA, and Computational Radiology and Artificial Intelligence (CRAI) Research Group (J.A.O), Oslo University Hospital, Oslo, Norway.
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Elizabeth Mormino
From the Department of Radiology (D.K., J.A.O., A.K., B.C.H., E.B.,), and the Department of Neurology and Neurological Sciences (C.B.Y., E.M.), Stanford University, Stanford, California, USA, and Computational Radiology and Artificial Intelligence (CRAI) Research Group (J.A.O), Oslo University Hospital, Oslo, Norway.
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Greg Zaharchuk
From the Department of Radiology (D.K., J.A.O., A.K., B.C.H., E.B.,), and the Department of Neurology and Neurological Sciences (C.B.Y., E.M.), Stanford University, Stanford, California, USA, and Computational Radiology and Artificial Intelligence (CRAI) Research Group (J.A.O), Oslo University Hospital, Oslo, Norway.
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From the Department of Radiology (D.K., J.A.O., A.K., B.C.H., E.B.,), and the Department of Neurology and Neurological Sciences (C.B.Y., E.M.), Stanford University, Stanford, California, USA, and Computational Radiology and Artificial Intelligence (CRAI) Research Group (J.A.O), Oslo University Hospital, Oslo, Norway.
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Article Information

ajnr.A8899
DOI 
https://doi.org/10.3174/ajnr.A8899
PubMed 
40579043

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Published online June 27, 2025.

Copyright & Usage 
© 2025 by American Journal of Neuroradiology

Author Information

  1. Donghoon Kim,
  2. Jon André Ottesen,
  3. Ashwin Kumar,
  4. Brandon C. Ho,
  5. Elsa Bismuth,
  6. Christina B. Young,
  7. Elizabeth Mormino,
  8. Greg Zaharchuk,
  9. for the Alzheimer’s Disease Neuroimaging Initiative
  1. From the Department of Radiology (D.K., J.A.O., A.K., B.C.H., E.B.,), and the Department of Neurology and Neurological Sciences (C.B.Y., E.M.), Stanford University, Stanford, California, USA, and Computational Radiology and Artificial Intelligence (CRAI) Research Group (J.A.O), Oslo University Hospital, Oslo, Norway.
  1. Please address correspondence to Greg Zaharchuk, MD, PhD, Department of Radiology, Stanford University, 1201 Welch Rd, Stanford, CA, 94305, USA; gregz{at}stanford.edu

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Cite this article
Accepted Manuscript
Donghoon Kim, Jon André Ottesen, Ashwin Kumar, Brandon C. Ho, Elsa Bismuth, Christina B. Young, Elizabeth Mormino, Greg Zaharchuk, for the Alzheimer’s Disease Neuroimaging Initiative
Deep Learning-Based Prediction of PET Amyloid Status Using MRI
American Journal of Neuroradiology Jun 2025, ajnr.A8899; DOI: 10.3174/ajnr.A8899

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Accepted Manuscript
Deep Learning-Based Prediction of PET Amyloid Status Using MRI
Donghoon Kim, Jon André Ottesen, Ashwin Kumar, Brandon C. Ho, Elsa Bismuth, Christina B. Young, Elizabeth Mormino, Greg Zaharchuk, for the Alzheimer’s Disease Neuroimaging Initiative
American Journal of Neuroradiology Jun 2025, ajnr.A8899; DOI: 10.3174/ajnr.A8899
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