FDG-PET intensity normalization improves radiomics- based survival prediction in oropharyngeal cancer patients: a comparison of the SUV with alternative normalization techniques

From the Department of Radiology, Columbia University Medical Center, New York, NY, USA (Seyedmehdi Payabvash, MD), Department of Otorhinolaryngology, LMU Clinic of Ludwig-Maximilians-University of Munich, Munich, Germany (Kariem Sharaf, MD, DDS; Andrea Schreier, MD; Jasmin Krenn; Martin Canis, MD; Philipp Baumeister, MD; Christoph A. Reichel, MD; Stefan P. Haider, MD), Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (Tal Zeevi, MSc; Moritz Gross; Amit Mahajan, MD; Stefan P. Haider, MD), Charité Center for Diagnostic and Interventional Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Moritz Gross), Department of Radiation Oncology, Dana-Farber- Cancer-Institute, Harvard Medical School, Boston, MA, USA (Benjamin H. Kann, MD), Division of Otolaryngology, Yale School of Medicine, New Haven, CT, USA (Benjamin L. Judson, MD), Department of Pathology, Yale School of Medicine, New Haven, CT, USA (Manju L. Prasad, MD), Section of Medical Oncology, Yale School of Medicine, New Haven, CT, USA (Barbara Burtness, MD), Bavarian Cancer Research Center (BZKF), Munich, Germany (Philipp Baumeister, MD), and Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA (Mariam Aboian, MD/PhD).

From the Department of Radiology, Columbia University Medical Center, New York, NY, USA (Seyedmehdi Payabvash, MD), Department of Otorhinolaryngology, LMU Clinic of Ludwig-Maximilians-University of Munich, Munich, Germany (Kariem Sharaf, MD, DDS; Andrea Schreier, MD; Jasmin Krenn; Martin Canis, MD; Philipp Baumeister, MD; Christoph A. Reichel, MD; Stefan P. Haider, MD), Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (Tal Zeevi, MSc; Moritz Gross; Amit Mahajan, MD; Stefan P. Haider, MD), Charité Center for Diagnostic and Interventional Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Moritz Gross), Department of Radiation Oncology, Dana-Farber- Cancer-Institute, Harvard Medical School, Boston, MA, USA (Benjamin H. Kann, MD), Division of Otolaryngology, Yale School of Medicine, New Haven, CT, USA (Benjamin L. Judson, MD), Department of Pathology, Yale School of Medicine, New Haven, CT, USA (Manju L. Prasad, MD), Section of Medical Oncology, Yale School of Medicine, New Haven, CT, USA (Barbara Burtness, MD), Bavarian Cancer Research Center (BZKF), Munich, Germany (Philipp Baumeister, MD), and Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA (Mariam Aboian, MD/PhD).

From the Department of Radiology, Columbia University Medical Center, New York, NY, USA (Seyedmehdi Payabvash, MD), Department of Otorhinolaryngology, LMU Clinic of Ludwig-Maximilians-University of Munich, Munich, Germany (Kariem Sharaf, MD, DDS; Andrea Schreier, MD; Jasmin Krenn; Martin Canis, MD; Philipp Baumeister, MD; Christoph A. Reichel, MD; Stefan P. Haider, MD), Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (Tal Zeevi, MSc; Moritz Gross; Amit Mahajan, MD; Stefan P. Haider, MD), Charité Center for Diagnostic and Interventional Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Moritz Gross), Department of Radiation Oncology, Dana-Farber- Cancer-Institute, Harvard Medical School, Boston, MA, USA (Benjamin H. Kann, MD), Division of Otolaryngology, Yale School of Medicine, New Haven, CT, USA (Benjamin L. Judson, MD), Department of Pathology, Yale School of Medicine, New Haven, CT, USA (Manju L. Prasad, MD), Section of Medical Oncology, Yale School of Medicine, New Haven, CT, USA (Barbara Burtness, MD), Bavarian Cancer Research Center (BZKF), Munich, Germany (Philipp Baumeister, MD), and Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA (Mariam Aboian, MD/PhD).

From the Department of Radiology, Columbia University Medical Center, New York, NY, USA (Seyedmehdi Payabvash, MD), Department of Otorhinolaryngology, LMU Clinic of Ludwig-Maximilians-University of Munich, Munich, Germany (Kariem Sharaf, MD, DDS; Andrea Schreier, MD; Jasmin Krenn; Martin Canis, MD; Philipp Baumeister, MD; Christoph A. Reichel, MD; Stefan P. Haider, MD), Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (Tal Zeevi, MSc; Moritz Gross; Amit Mahajan, MD; Stefan P. Haider, MD), Charité Center for Diagnostic and Interventional Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Moritz Gross), Department of Radiation Oncology, Dana-Farber- Cancer-Institute, Harvard Medical School, Boston, MA, USA (Benjamin H. Kann, MD), Division of Otolaryngology, Yale School of Medicine, New Haven, CT, USA (Benjamin L. Judson, MD), Department of Pathology, Yale School of Medicine, New Haven, CT, USA (Manju L. Prasad, MD), Section of Medical Oncology, Yale School of Medicine, New Haven, CT, USA (Barbara Burtness, MD), Bavarian Cancer Research Center (BZKF), Munich, Germany (Philipp Baumeister, MD), and Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA (Mariam Aboian, MD/PhD).

From the Department of Radiology, Columbia University Medical Center, New York, NY, USA (Seyedmehdi Payabvash, MD), Department of Otorhinolaryngology, LMU Clinic of Ludwig-Maximilians-University of Munich, Munich, Germany (Kariem Sharaf, MD, DDS; Andrea Schreier, MD; Jasmin Krenn; Martin Canis, MD; Philipp Baumeister, MD; Christoph A. Reichel, MD; Stefan P. Haider, MD), Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (Tal Zeevi, MSc; Moritz Gross; Amit Mahajan, MD; Stefan P. Haider, MD), Charité Center for Diagnostic and Interventional Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Moritz Gross), Department of Radiation Oncology, Dana-Farber- Cancer-Institute, Harvard Medical School, Boston, MA, USA (Benjamin H. Kann, MD), Division of Otolaryngology, Yale School of Medicine, New Haven, CT, USA (Benjamin L. Judson, MD), Department of Pathology, Yale School of Medicine, New Haven, CT, USA (Manju L. Prasad, MD), Section of Medical Oncology, Yale School of Medicine, New Haven, CT, USA (Barbara Burtness, MD), Bavarian Cancer Research Center (BZKF), Munich, Germany (Philipp Baumeister, MD), and Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA (Mariam Aboian, MD/PhD).

From the Department of Radiology, Columbia University Medical Center, New York, NY, USA (Seyedmehdi Payabvash, MD), Department of Otorhinolaryngology, LMU Clinic of Ludwig-Maximilians-University of Munich, Munich, Germany (Kariem Sharaf, MD, DDS; Andrea Schreier, MD; Jasmin Krenn; Martin Canis, MD; Philipp Baumeister, MD; Christoph A. Reichel, MD; Stefan P. Haider, MD), Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (Tal Zeevi, MSc; Moritz Gross; Amit Mahajan, MD; Stefan P. Haider, MD), Charité Center for Diagnostic and Interventional Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Moritz Gross), Department of Radiation Oncology, Dana-Farber- Cancer-Institute, Harvard Medical School, Boston, MA, USA (Benjamin H. Kann, MD), Division of Otolaryngology, Yale School of Medicine, New Haven, CT, USA (Benjamin L. Judson, MD), Department of Pathology, Yale School of Medicine, New Haven, CT, USA (Manju L. Prasad, MD), Section of Medical Oncology, Yale School of Medicine, New Haven, CT, USA (Barbara Burtness, MD), Bavarian Cancer Research Center (BZKF), Munich, Germany (Philipp Baumeister, MD), and Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA (Mariam Aboian, MD/PhD).

From the Department of Radiology, Columbia University Medical Center, New York, NY, USA (Seyedmehdi Payabvash, MD), Department of Otorhinolaryngology, LMU Clinic of Ludwig-Maximilians-University of Munich, Munich, Germany (Kariem Sharaf, MD, DDS; Andrea Schreier, MD; Jasmin Krenn; Martin Canis, MD; Philipp Baumeister, MD; Christoph A. Reichel, MD; Stefan P. Haider, MD), Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (Tal Zeevi, MSc; Moritz Gross; Amit Mahajan, MD; Stefan P. Haider, MD), Charité Center for Diagnostic and Interventional Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Moritz Gross), Department of Radiation Oncology, Dana-Farber- Cancer-Institute, Harvard Medical School, Boston, MA, USA (Benjamin H. Kann, MD), Division of Otolaryngology, Yale School of Medicine, New Haven, CT, USA (Benjamin L. Judson, MD), Department of Pathology, Yale School of Medicine, New Haven, CT, USA (Manju L. Prasad, MD), Section of Medical Oncology, Yale School of Medicine, New Haven, CT, USA (Barbara Burtness, MD), Bavarian Cancer Research Center (BZKF), Munich, Germany (Philipp Baumeister, MD), and Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA (Mariam Aboian, MD/PhD).

From the Department of Radiology, Columbia University Medical Center, New York, NY, USA (Seyedmehdi Payabvash, MD), Department of Otorhinolaryngology, LMU Clinic of Ludwig-Maximilians-University of Munich, Munich, Germany (Kariem Sharaf, MD, DDS; Andrea Schreier, MD; Jasmin Krenn; Martin Canis, MD; Philipp Baumeister, MD; Christoph A. Reichel, MD; Stefan P. Haider, MD), Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (Tal Zeevi, MSc; Moritz Gross; Amit Mahajan, MD; Stefan P. Haider, MD), Charité Center for Diagnostic and Interventional Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Moritz Gross), Department of Radiation Oncology, Dana-Farber- Cancer-Institute, Harvard Medical School, Boston, MA, USA (Benjamin H. Kann, MD), Division of Otolaryngology, Yale School of Medicine, New Haven, CT, USA (Benjamin L. Judson, MD), Department of Pathology, Yale School of Medicine, New Haven, CT, USA (Manju L. Prasad, MD), Section of Medical Oncology, Yale School of Medicine, New Haven, CT, USA (Barbara Burtness, MD), Bavarian Cancer Research Center (BZKF), Munich, Germany (Philipp Baumeister, MD), and Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA (Mariam Aboian, MD/PhD).

From the Department of Radiology, Columbia University Medical Center, New York, NY, USA (Seyedmehdi Payabvash, MD), Department of Otorhinolaryngology, LMU Clinic of Ludwig-Maximilians-University of Munich, Munich, Germany (Kariem Sharaf, MD, DDS; Andrea Schreier, MD; Jasmin Krenn; Martin Canis, MD; Philipp Baumeister, MD; Christoph A. Reichel, MD; Stefan P. Haider, MD), Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (Tal Zeevi, MSc; Moritz Gross; Amit Mahajan, MD; Stefan P. Haider, MD), Charité Center for Diagnostic and Interventional Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Moritz Gross), Department of Radiation Oncology, Dana-Farber- Cancer-Institute, Harvard Medical School, Boston, MA, USA (Benjamin H. Kann, MD), Division of Otolaryngology, Yale School of Medicine, New Haven, CT, USA (Benjamin L. Judson, MD), Department of Pathology, Yale School of Medicine, New Haven, CT, USA (Manju L. Prasad, MD), Section of Medical Oncology, Yale School of Medicine, New Haven, CT, USA (Barbara Burtness, MD), Bavarian Cancer Research Center (BZKF), Munich, Germany (Philipp Baumeister, MD), and Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA (Mariam Aboian, MD/PhD).

From the Department of Radiology, Columbia University Medical Center, New York, NY, USA (Seyedmehdi Payabvash, MD), Department of Otorhinolaryngology, LMU Clinic of Ludwig-Maximilians-University of Munich, Munich, Germany (Kariem Sharaf, MD, DDS; Andrea Schreier, MD; Jasmin Krenn; Martin Canis, MD; Philipp Baumeister, MD; Christoph A. Reichel, MD; Stefan P. Haider, MD), Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (Tal Zeevi, MSc; Moritz Gross; Amit Mahajan, MD; Stefan P. Haider, MD), Charité Center for Diagnostic and Interventional Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Moritz Gross), Department of Radiation Oncology, Dana-Farber- Cancer-Institute, Harvard Medical School, Boston, MA, USA (Benjamin H. Kann, MD), Division of Otolaryngology, Yale School of Medicine, New Haven, CT, USA (Benjamin L. Judson, MD), Department of Pathology, Yale School of Medicine, New Haven, CT, USA (Manju L. Prasad, MD), Section of Medical Oncology, Yale School of Medicine, New Haven, CT, USA (Barbara Burtness, MD), Bavarian Cancer Research Center (BZKF), Munich, Germany (Philipp Baumeister, MD), and Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA (Mariam Aboian, MD/PhD).

From the Department of Radiology, Columbia University Medical Center, New York, NY, USA (Seyedmehdi Payabvash, MD), Department of Otorhinolaryngology, LMU Clinic of Ludwig-Maximilians-University of Munich, Munich, Germany (Kariem Sharaf, MD, DDS; Andrea Schreier, MD; Jasmin Krenn; Martin Canis, MD; Philipp Baumeister, MD; Christoph A. Reichel, MD; Stefan P. Haider, MD), Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (Tal Zeevi, MSc; Moritz Gross; Amit Mahajan, MD; Stefan P. Haider, MD), Charité Center for Diagnostic and Interventional Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Moritz Gross), Department of Radiation Oncology, Dana-Farber- Cancer-Institute, Harvard Medical School, Boston, MA, USA (Benjamin H. Kann, MD), Division of Otolaryngology, Yale School of Medicine, New Haven, CT, USA (Benjamin L. Judson, MD), Department of Pathology, Yale School of Medicine, New Haven, CT, USA (Manju L. Prasad, MD), Section of Medical Oncology, Yale School of Medicine, New Haven, CT, USA (Barbara Burtness, MD), Bavarian Cancer Research Center (BZKF), Munich, Germany (Philipp Baumeister, MD), and Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA (Mariam Aboian, MD/PhD).

From the Department of Radiology, Columbia University Medical Center, New York, NY, USA (Seyedmehdi Payabvash, MD), Department of Otorhinolaryngology, LMU Clinic of Ludwig-Maximilians-University of Munich, Munich, Germany (Kariem Sharaf, MD, DDS; Andrea Schreier, MD; Jasmin Krenn; Martin Canis, MD; Philipp Baumeister, MD; Christoph A. Reichel, MD; Stefan P. Haider, MD), Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (Tal Zeevi, MSc; Moritz Gross; Amit Mahajan, MD; Stefan P. Haider, MD), Charité Center for Diagnostic and Interventional Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Moritz Gross), Department of Radiation Oncology, Dana-Farber- Cancer-Institute, Harvard Medical School, Boston, MA, USA (Benjamin H. Kann, MD), Division of Otolaryngology, Yale School of Medicine, New Haven, CT, USA (Benjamin L. Judson, MD), Department of Pathology, Yale School of Medicine, New Haven, CT, USA (Manju L. Prasad, MD), Section of Medical Oncology, Yale School of Medicine, New Haven, CT, USA (Barbara Burtness, MD), Bavarian Cancer Research Center (BZKF), Munich, Germany (Philipp Baumeister, MD), and Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA (Mariam Aboian, MD/PhD).

From the Department of Radiology, Columbia University Medical Center, New York, NY, USA (Seyedmehdi Payabvash, MD), Department of Otorhinolaryngology, LMU Clinic of Ludwig-Maximilians-University of Munich, Munich, Germany (Kariem Sharaf, MD, DDS; Andrea Schreier, MD; Jasmin Krenn; Martin Canis, MD; Philipp Baumeister, MD; Christoph A. Reichel, MD; Stefan P. Haider, MD), Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (Tal Zeevi, MSc; Moritz Gross; Amit Mahajan, MD; Stefan P. Haider, MD), Charité Center for Diagnostic and Interventional Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Moritz Gross), Department of Radiation Oncology, Dana-Farber- Cancer-Institute, Harvard Medical School, Boston, MA, USA (Benjamin H. Kann, MD), Division of Otolaryngology, Yale School of Medicine, New Haven, CT, USA (Benjamin L. Judson, MD), Department of Pathology, Yale School of Medicine, New Haven, CT, USA (Manju L. Prasad, MD), Section of Medical Oncology, Yale School of Medicine, New Haven, CT, USA (Barbara Burtness, MD), Bavarian Cancer Research Center (BZKF), Munich, Germany (Philipp Baumeister, MD), and Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA (Mariam Aboian, MD/PhD).

From the Department of Radiology, Columbia University Medical Center, New York, NY, USA (Seyedmehdi Payabvash, MD), Department of Otorhinolaryngology, LMU Clinic of Ludwig-Maximilians-University of Munich, Munich, Germany (Kariem Sharaf, MD, DDS; Andrea Schreier, MD; Jasmin Krenn; Martin Canis, MD; Philipp Baumeister, MD; Christoph A. Reichel, MD; Stefan P. Haider, MD), Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (Tal Zeevi, MSc; Moritz Gross; Amit Mahajan, MD; Stefan P. Haider, MD), Charité Center for Diagnostic and Interventional Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Moritz Gross), Department of Radiation Oncology, Dana-Farber- Cancer-Institute, Harvard Medical School, Boston, MA, USA (Benjamin H. Kann, MD), Division of Otolaryngology, Yale School of Medicine, New Haven, CT, USA (Benjamin L. Judson, MD), Department of Pathology, Yale School of Medicine, New Haven, CT, USA (Manju L. Prasad, MD), Section of Medical Oncology, Yale School of Medicine, New Haven, CT, USA (Barbara Burtness, MD), Bavarian Cancer Research Center (BZKF), Munich, Germany (Philipp Baumeister, MD), and Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA (Mariam Aboian, MD/PhD).

From the Department of Radiology, Columbia University Medical Center, New York, NY, USA (Seyedmehdi Payabvash, MD), Department of Otorhinolaryngology, LMU Clinic of Ludwig-Maximilians-University of Munich, Munich, Germany (Kariem Sharaf, MD, DDS; Andrea Schreier, MD; Jasmin Krenn; Martin Canis, MD; Philipp Baumeister, MD; Christoph A. Reichel, MD; Stefan P. Haider, MD), Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (Tal Zeevi, MSc; Moritz Gross; Amit Mahajan, MD; Stefan P. Haider, MD), Charité Center for Diagnostic and Interventional Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Moritz Gross), Department of Radiation Oncology, Dana-Farber- Cancer-Institute, Harvard Medical School, Boston, MA, USA (Benjamin H. Kann, MD), Division of Otolaryngology, Yale School of Medicine, New Haven, CT, USA (Benjamin L. Judson, MD), Department of Pathology, Yale School of Medicine, New Haven, CT, USA (Manju L. Prasad, MD), Section of Medical Oncology, Yale School of Medicine, New Haven, CT, USA (Barbara Burtness, MD), Bavarian Cancer Research Center (BZKF), Munich, Germany (Philipp Baumeister, MD), and Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA (Mariam Aboian, MD/PhD).

From the Department of Radiology, Columbia University Medical Center, New York, NY, USA (Seyedmehdi Payabvash, MD), Department of Otorhinolaryngology, LMU Clinic of Ludwig-Maximilians-University of Munich, Munich, Germany (Kariem Sharaf, MD, DDS; Andrea Schreier, MD; Jasmin Krenn; Martin Canis, MD; Philipp Baumeister, MD; Christoph A. Reichel, MD; Stefan P. Haider, MD), Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (Tal Zeevi, MSc; Moritz Gross; Amit Mahajan, MD; Stefan P. Haider, MD), Charité Center for Diagnostic and Interventional Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Moritz Gross), Department of Radiation Oncology, Dana-Farber- Cancer-Institute, Harvard Medical School, Boston, MA, USA (Benjamin H. Kann, MD), Division of Otolaryngology, Yale School of Medicine, New Haven, CT, USA (Benjamin L. Judson, MD), Department of Pathology, Yale School of Medicine, New Haven, CT, USA (Manju L. Prasad, MD), Section of Medical Oncology, Yale School of Medicine, New Haven, CT, USA (Barbara Burtness, MD), Bavarian Cancer Research Center (BZKF), Munich, Germany (Philipp Baumeister, MD), and Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA (Mariam Aboian, MD/PhD).