Research ArticleORIGINAL RESEARCH
Image-Based Search in Radiology: Identification of Brain Tumor Subtypes within Databases using MRI-Based Radiomic Features
Marc von Reppert, Saahil Chadha, Klara Willms, Arman Avesta, Nazanin Maleki, Tal Zeevi, Jan Lost, Niklas Tillmanns, Leon Jekel, Sara Merkaj, IBSR Consortium, MingDe Lin, Karl-Titus Hoffmann, Sanjay Aneja and Mariam S. Aboian
American Journal of Neuroradiology April 2025, ajnr.A8805; DOI: https://doi.org/10.3174/ajnr.A8805
Marc von Reppert
From the University of Leipzig, Leipzig, Germany (M.V.R., K.L., K.T.F.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (S.C., A.A.); Center for Outcomes Research and Evaluation, Yale School of Medicine, New Haven, CT, USA (S.C., S.A.); Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA (A.A.); Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA (N.M., M.S.A.); Center for Translational Imaging Analysis and Machine Learning, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (T.Z.); Department of Neurosurgery, Heinrich-Heine-University, Moorenstrasse 5, 40225 Duesseldorf, Germany (J.L.); Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, 40225, Dusseldorf, Germany (N.T.); University of Duisburg-Essen, 45147 Essen, Germany (L.J.); DKFZ Division of Translational Neuro-oncology at the WTZ, German Cancer Consortium, DKTK Partner Site, University Hospital Essen, 45147 Essen, Germany (L.J.); University of Ulm, Ulm, Germany (S.M.); Visage Imaging, Inc., San Diego, CA, USA (M.D.L); Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA (S.A.); IBSR consortium: Manpreet Kaur (Ludwig Maximilian University, Munich, Germany), Divya Ramakrishnan (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Khaled Bousabarah (Visage Imaging GmbH, Berlin, Germany), Nicolas Linder (University of Leipzig, Leipzig, Germany), Sarah M. Jacobs (Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands), Francesca Conti (Università di Roma -La Sapienza), Gabriel Cassinelli Petersen (University of Göttingen, Göttingen, Germany), Ujjwal Baid (Indiana University School of Medicine, Indianapolis, IN, USA), Ichiro Ikuta (Department of Radiology, Mayo Clinic Comprehensive Cancer Center, Phoenix, AZ), Fatima Memon (Carolina Radiology, Myrtle Beach, SC, USA), Claudia Kirsch (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Melissa Davis (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Spyridon Bakas (Indiana University School of Medicine, Indianapolis, IN, USA)
Saahil Chadha
From the University of Leipzig, Leipzig, Germany (M.V.R., K.L., K.T.F.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (S.C., A.A.); Center for Outcomes Research and Evaluation, Yale School of Medicine, New Haven, CT, USA (S.C., S.A.); Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA (A.A.); Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA (N.M., M.S.A.); Center for Translational Imaging Analysis and Machine Learning, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (T.Z.); Department of Neurosurgery, Heinrich-Heine-University, Moorenstrasse 5, 40225 Duesseldorf, Germany (J.L.); Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, 40225, Dusseldorf, Germany (N.T.); University of Duisburg-Essen, 45147 Essen, Germany (L.J.); DKFZ Division of Translational Neuro-oncology at the WTZ, German Cancer Consortium, DKTK Partner Site, University Hospital Essen, 45147 Essen, Germany (L.J.); University of Ulm, Ulm, Germany (S.M.); Visage Imaging, Inc., San Diego, CA, USA (M.D.L); Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA (S.A.); IBSR consortium: Manpreet Kaur (Ludwig Maximilian University, Munich, Germany), Divya Ramakrishnan (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Khaled Bousabarah (Visage Imaging GmbH, Berlin, Germany), Nicolas Linder (University of Leipzig, Leipzig, Germany), Sarah M. Jacobs (Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands), Francesca Conti (Università di Roma -La Sapienza), Gabriel Cassinelli Petersen (University of Göttingen, Göttingen, Germany), Ujjwal Baid (Indiana University School of Medicine, Indianapolis, IN, USA), Ichiro Ikuta (Department of Radiology, Mayo Clinic Comprehensive Cancer Center, Phoenix, AZ), Fatima Memon (Carolina Radiology, Myrtle Beach, SC, USA), Claudia Kirsch (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Melissa Davis (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Spyridon Bakas (Indiana University School of Medicine, Indianapolis, IN, USA)
Klara Willms
From the University of Leipzig, Leipzig, Germany (M.V.R., K.L., K.T.F.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (S.C., A.A.); Center for Outcomes Research and Evaluation, Yale School of Medicine, New Haven, CT, USA (S.C., S.A.); Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA (A.A.); Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA (N.M., M.S.A.); Center for Translational Imaging Analysis and Machine Learning, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (T.Z.); Department of Neurosurgery, Heinrich-Heine-University, Moorenstrasse 5, 40225 Duesseldorf, Germany (J.L.); Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, 40225, Dusseldorf, Germany (N.T.); University of Duisburg-Essen, 45147 Essen, Germany (L.J.); DKFZ Division of Translational Neuro-oncology at the WTZ, German Cancer Consortium, DKTK Partner Site, University Hospital Essen, 45147 Essen, Germany (L.J.); University of Ulm, Ulm, Germany (S.M.); Visage Imaging, Inc., San Diego, CA, USA (M.D.L); Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA (S.A.); IBSR consortium: Manpreet Kaur (Ludwig Maximilian University, Munich, Germany), Divya Ramakrishnan (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Khaled Bousabarah (Visage Imaging GmbH, Berlin, Germany), Nicolas Linder (University of Leipzig, Leipzig, Germany), Sarah M. Jacobs (Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands), Francesca Conti (Università di Roma -La Sapienza), Gabriel Cassinelli Petersen (University of Göttingen, Göttingen, Germany), Ujjwal Baid (Indiana University School of Medicine, Indianapolis, IN, USA), Ichiro Ikuta (Department of Radiology, Mayo Clinic Comprehensive Cancer Center, Phoenix, AZ), Fatima Memon (Carolina Radiology, Myrtle Beach, SC, USA), Claudia Kirsch (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Melissa Davis (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Spyridon Bakas (Indiana University School of Medicine, Indianapolis, IN, USA)
Arman Avesta
From the University of Leipzig, Leipzig, Germany (M.V.R., K.L., K.T.F.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (S.C., A.A.); Center for Outcomes Research and Evaluation, Yale School of Medicine, New Haven, CT, USA (S.C., S.A.); Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA (A.A.); Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA (N.M., M.S.A.); Center for Translational Imaging Analysis and Machine Learning, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (T.Z.); Department of Neurosurgery, Heinrich-Heine-University, Moorenstrasse 5, 40225 Duesseldorf, Germany (J.L.); Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, 40225, Dusseldorf, Germany (N.T.); University of Duisburg-Essen, 45147 Essen, Germany (L.J.); DKFZ Division of Translational Neuro-oncology at the WTZ, German Cancer Consortium, DKTK Partner Site, University Hospital Essen, 45147 Essen, Germany (L.J.); University of Ulm, Ulm, Germany (S.M.); Visage Imaging, Inc., San Diego, CA, USA (M.D.L); Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA (S.A.); IBSR consortium: Manpreet Kaur (Ludwig Maximilian University, Munich, Germany), Divya Ramakrishnan (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Khaled Bousabarah (Visage Imaging GmbH, Berlin, Germany), Nicolas Linder (University of Leipzig, Leipzig, Germany), Sarah M. Jacobs (Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands), Francesca Conti (Università di Roma -La Sapienza), Gabriel Cassinelli Petersen (University of Göttingen, Göttingen, Germany), Ujjwal Baid (Indiana University School of Medicine, Indianapolis, IN, USA), Ichiro Ikuta (Department of Radiology, Mayo Clinic Comprehensive Cancer Center, Phoenix, AZ), Fatima Memon (Carolina Radiology, Myrtle Beach, SC, USA), Claudia Kirsch (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Melissa Davis (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Spyridon Bakas (Indiana University School of Medicine, Indianapolis, IN, USA)
Nazanin Maleki
From the University of Leipzig, Leipzig, Germany (M.V.R., K.L., K.T.F.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (S.C., A.A.); Center for Outcomes Research and Evaluation, Yale School of Medicine, New Haven, CT, USA (S.C., S.A.); Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA (A.A.); Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA (N.M., M.S.A.); Center for Translational Imaging Analysis and Machine Learning, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (T.Z.); Department of Neurosurgery, Heinrich-Heine-University, Moorenstrasse 5, 40225 Duesseldorf, Germany (J.L.); Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, 40225, Dusseldorf, Germany (N.T.); University of Duisburg-Essen, 45147 Essen, Germany (L.J.); DKFZ Division of Translational Neuro-oncology at the WTZ, German Cancer Consortium, DKTK Partner Site, University Hospital Essen, 45147 Essen, Germany (L.J.); University of Ulm, Ulm, Germany (S.M.); Visage Imaging, Inc., San Diego, CA, USA (M.D.L); Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA (S.A.); IBSR consortium: Manpreet Kaur (Ludwig Maximilian University, Munich, Germany), Divya Ramakrishnan (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Khaled Bousabarah (Visage Imaging GmbH, Berlin, Germany), Nicolas Linder (University of Leipzig, Leipzig, Germany), Sarah M. Jacobs (Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands), Francesca Conti (Università di Roma -La Sapienza), Gabriel Cassinelli Petersen (University of Göttingen, Göttingen, Germany), Ujjwal Baid (Indiana University School of Medicine, Indianapolis, IN, USA), Ichiro Ikuta (Department of Radiology, Mayo Clinic Comprehensive Cancer Center, Phoenix, AZ), Fatima Memon (Carolina Radiology, Myrtle Beach, SC, USA), Claudia Kirsch (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Melissa Davis (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Spyridon Bakas (Indiana University School of Medicine, Indianapolis, IN, USA)
Tal Zeevi
From the University of Leipzig, Leipzig, Germany (M.V.R., K.L., K.T.F.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (S.C., A.A.); Center for Outcomes Research and Evaluation, Yale School of Medicine, New Haven, CT, USA (S.C., S.A.); Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA (A.A.); Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA (N.M., M.S.A.); Center for Translational Imaging Analysis and Machine Learning, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (T.Z.); Department of Neurosurgery, Heinrich-Heine-University, Moorenstrasse 5, 40225 Duesseldorf, Germany (J.L.); Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, 40225, Dusseldorf, Germany (N.T.); University of Duisburg-Essen, 45147 Essen, Germany (L.J.); DKFZ Division of Translational Neuro-oncology at the WTZ, German Cancer Consortium, DKTK Partner Site, University Hospital Essen, 45147 Essen, Germany (L.J.); University of Ulm, Ulm, Germany (S.M.); Visage Imaging, Inc., San Diego, CA, USA (M.D.L); Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA (S.A.); IBSR consortium: Manpreet Kaur (Ludwig Maximilian University, Munich, Germany), Divya Ramakrishnan (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Khaled Bousabarah (Visage Imaging GmbH, Berlin, Germany), Nicolas Linder (University of Leipzig, Leipzig, Germany), Sarah M. Jacobs (Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands), Francesca Conti (Università di Roma -La Sapienza), Gabriel Cassinelli Petersen (University of Göttingen, Göttingen, Germany), Ujjwal Baid (Indiana University School of Medicine, Indianapolis, IN, USA), Ichiro Ikuta (Department of Radiology, Mayo Clinic Comprehensive Cancer Center, Phoenix, AZ), Fatima Memon (Carolina Radiology, Myrtle Beach, SC, USA), Claudia Kirsch (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Melissa Davis (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Spyridon Bakas (Indiana University School of Medicine, Indianapolis, IN, USA)
Jan Lost
From the University of Leipzig, Leipzig, Germany (M.V.R., K.L., K.T.F.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (S.C., A.A.); Center for Outcomes Research and Evaluation, Yale School of Medicine, New Haven, CT, USA (S.C., S.A.); Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA (A.A.); Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA (N.M., M.S.A.); Center for Translational Imaging Analysis and Machine Learning, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (T.Z.); Department of Neurosurgery, Heinrich-Heine-University, Moorenstrasse 5, 40225 Duesseldorf, Germany (J.L.); Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, 40225, Dusseldorf, Germany (N.T.); University of Duisburg-Essen, 45147 Essen, Germany (L.J.); DKFZ Division of Translational Neuro-oncology at the WTZ, German Cancer Consortium, DKTK Partner Site, University Hospital Essen, 45147 Essen, Germany (L.J.); University of Ulm, Ulm, Germany (S.M.); Visage Imaging, Inc., San Diego, CA, USA (M.D.L); Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA (S.A.); IBSR consortium: Manpreet Kaur (Ludwig Maximilian University, Munich, Germany), Divya Ramakrishnan (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Khaled Bousabarah (Visage Imaging GmbH, Berlin, Germany), Nicolas Linder (University of Leipzig, Leipzig, Germany), Sarah M. Jacobs (Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands), Francesca Conti (Università di Roma -La Sapienza), Gabriel Cassinelli Petersen (University of Göttingen, Göttingen, Germany), Ujjwal Baid (Indiana University School of Medicine, Indianapolis, IN, USA), Ichiro Ikuta (Department of Radiology, Mayo Clinic Comprehensive Cancer Center, Phoenix, AZ), Fatima Memon (Carolina Radiology, Myrtle Beach, SC, USA), Claudia Kirsch (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Melissa Davis (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Spyridon Bakas (Indiana University School of Medicine, Indianapolis, IN, USA)
Niklas Tillmanns
From the University of Leipzig, Leipzig, Germany (M.V.R., K.L., K.T.F.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (S.C., A.A.); Center for Outcomes Research and Evaluation, Yale School of Medicine, New Haven, CT, USA (S.C., S.A.); Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA (A.A.); Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA (N.M., M.S.A.); Center for Translational Imaging Analysis and Machine Learning, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (T.Z.); Department of Neurosurgery, Heinrich-Heine-University, Moorenstrasse 5, 40225 Duesseldorf, Germany (J.L.); Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, 40225, Dusseldorf, Germany (N.T.); University of Duisburg-Essen, 45147 Essen, Germany (L.J.); DKFZ Division of Translational Neuro-oncology at the WTZ, German Cancer Consortium, DKTK Partner Site, University Hospital Essen, 45147 Essen, Germany (L.J.); University of Ulm, Ulm, Germany (S.M.); Visage Imaging, Inc., San Diego, CA, USA (M.D.L); Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA (S.A.); IBSR consortium: Manpreet Kaur (Ludwig Maximilian University, Munich, Germany), Divya Ramakrishnan (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Khaled Bousabarah (Visage Imaging GmbH, Berlin, Germany), Nicolas Linder (University of Leipzig, Leipzig, Germany), Sarah M. Jacobs (Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands), Francesca Conti (Università di Roma -La Sapienza), Gabriel Cassinelli Petersen (University of Göttingen, Göttingen, Germany), Ujjwal Baid (Indiana University School of Medicine, Indianapolis, IN, USA), Ichiro Ikuta (Department of Radiology, Mayo Clinic Comprehensive Cancer Center, Phoenix, AZ), Fatima Memon (Carolina Radiology, Myrtle Beach, SC, USA), Claudia Kirsch (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Melissa Davis (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Spyridon Bakas (Indiana University School of Medicine, Indianapolis, IN, USA)
Leon Jekel
From the University of Leipzig, Leipzig, Germany (M.V.R., K.L., K.T.F.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (S.C., A.A.); Center for Outcomes Research and Evaluation, Yale School of Medicine, New Haven, CT, USA (S.C., S.A.); Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA (A.A.); Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA (N.M., M.S.A.); Center for Translational Imaging Analysis and Machine Learning, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (T.Z.); Department of Neurosurgery, Heinrich-Heine-University, Moorenstrasse 5, 40225 Duesseldorf, Germany (J.L.); Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, 40225, Dusseldorf, Germany (N.T.); University of Duisburg-Essen, 45147 Essen, Germany (L.J.); DKFZ Division of Translational Neuro-oncology at the WTZ, German Cancer Consortium, DKTK Partner Site, University Hospital Essen, 45147 Essen, Germany (L.J.); University of Ulm, Ulm, Germany (S.M.); Visage Imaging, Inc., San Diego, CA, USA (M.D.L); Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA (S.A.); IBSR consortium: Manpreet Kaur (Ludwig Maximilian University, Munich, Germany), Divya Ramakrishnan (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Khaled Bousabarah (Visage Imaging GmbH, Berlin, Germany), Nicolas Linder (University of Leipzig, Leipzig, Germany), Sarah M. Jacobs (Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands), Francesca Conti (Università di Roma -La Sapienza), Gabriel Cassinelli Petersen (University of Göttingen, Göttingen, Germany), Ujjwal Baid (Indiana University School of Medicine, Indianapolis, IN, USA), Ichiro Ikuta (Department of Radiology, Mayo Clinic Comprehensive Cancer Center, Phoenix, AZ), Fatima Memon (Carolina Radiology, Myrtle Beach, SC, USA), Claudia Kirsch (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Melissa Davis (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Spyridon Bakas (Indiana University School of Medicine, Indianapolis, IN, USA)
Sara Merkaj
From the University of Leipzig, Leipzig, Germany (M.V.R., K.L., K.T.F.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (S.C., A.A.); Center for Outcomes Research and Evaluation, Yale School of Medicine, New Haven, CT, USA (S.C., S.A.); Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA (A.A.); Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA (N.M., M.S.A.); Center for Translational Imaging Analysis and Machine Learning, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (T.Z.); Department of Neurosurgery, Heinrich-Heine-University, Moorenstrasse 5, 40225 Duesseldorf, Germany (J.L.); Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, 40225, Dusseldorf, Germany (N.T.); University of Duisburg-Essen, 45147 Essen, Germany (L.J.); DKFZ Division of Translational Neuro-oncology at the WTZ, German Cancer Consortium, DKTK Partner Site, University Hospital Essen, 45147 Essen, Germany (L.J.); University of Ulm, Ulm, Germany (S.M.); Visage Imaging, Inc., San Diego, CA, USA (M.D.L); Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA (S.A.); IBSR consortium: Manpreet Kaur (Ludwig Maximilian University, Munich, Germany), Divya Ramakrishnan (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Khaled Bousabarah (Visage Imaging GmbH, Berlin, Germany), Nicolas Linder (University of Leipzig, Leipzig, Germany), Sarah M. Jacobs (Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands), Francesca Conti (Università di Roma -La Sapienza), Gabriel Cassinelli Petersen (University of Göttingen, Göttingen, Germany), Ujjwal Baid (Indiana University School of Medicine, Indianapolis, IN, USA), Ichiro Ikuta (Department of Radiology, Mayo Clinic Comprehensive Cancer Center, Phoenix, AZ), Fatima Memon (Carolina Radiology, Myrtle Beach, SC, USA), Claudia Kirsch (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Melissa Davis (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Spyridon Bakas (Indiana University School of Medicine, Indianapolis, IN, USA)
From the University of Leipzig, Leipzig, Germany (M.V.R., K.L., K.T.F.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (S.C., A.A.); Center for Outcomes Research and Evaluation, Yale School of Medicine, New Haven, CT, USA (S.C., S.A.); Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA (A.A.); Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA (N.M., M.S.A.); Center for Translational Imaging Analysis and Machine Learning, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (T.Z.); Department of Neurosurgery, Heinrich-Heine-University, Moorenstrasse 5, 40225 Duesseldorf, Germany (J.L.); Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, 40225, Dusseldorf, Germany (N.T.); University of Duisburg-Essen, 45147 Essen, Germany (L.J.); DKFZ Division of Translational Neuro-oncology at the WTZ, German Cancer Consortium, DKTK Partner Site, University Hospital Essen, 45147 Essen, Germany (L.J.); University of Ulm, Ulm, Germany (S.M.); Visage Imaging, Inc., San Diego, CA, USA (M.D.L); Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA (S.A.); IBSR consortium: Manpreet Kaur (Ludwig Maximilian University, Munich, Germany), Divya Ramakrishnan (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Khaled Bousabarah (Visage Imaging GmbH, Berlin, Germany), Nicolas Linder (University of Leipzig, Leipzig, Germany), Sarah M. Jacobs (Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands), Francesca Conti (Università di Roma -La Sapienza), Gabriel Cassinelli Petersen (University of Göttingen, Göttingen, Germany), Ujjwal Baid (Indiana University School of Medicine, Indianapolis, IN, USA), Ichiro Ikuta (Department of Radiology, Mayo Clinic Comprehensive Cancer Center, Phoenix, AZ), Fatima Memon (Carolina Radiology, Myrtle Beach, SC, USA), Claudia Kirsch (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Melissa Davis (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Spyridon Bakas (Indiana University School of Medicine, Indianapolis, IN, USA)
MingDe Lin
From the University of Leipzig, Leipzig, Germany (M.V.R., K.L., K.T.F.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (S.C., A.A.); Center for Outcomes Research and Evaluation, Yale School of Medicine, New Haven, CT, USA (S.C., S.A.); Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA (A.A.); Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA (N.M., M.S.A.); Center for Translational Imaging Analysis and Machine Learning, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (T.Z.); Department of Neurosurgery, Heinrich-Heine-University, Moorenstrasse 5, 40225 Duesseldorf, Germany (J.L.); Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, 40225, Dusseldorf, Germany (N.T.); University of Duisburg-Essen, 45147 Essen, Germany (L.J.); DKFZ Division of Translational Neuro-oncology at the WTZ, German Cancer Consortium, DKTK Partner Site, University Hospital Essen, 45147 Essen, Germany (L.J.); University of Ulm, Ulm, Germany (S.M.); Visage Imaging, Inc., San Diego, CA, USA (M.D.L); Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA (S.A.); IBSR consortium: Manpreet Kaur (Ludwig Maximilian University, Munich, Germany), Divya Ramakrishnan (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Khaled Bousabarah (Visage Imaging GmbH, Berlin, Germany), Nicolas Linder (University of Leipzig, Leipzig, Germany), Sarah M. Jacobs (Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands), Francesca Conti (Università di Roma -La Sapienza), Gabriel Cassinelli Petersen (University of Göttingen, Göttingen, Germany), Ujjwal Baid (Indiana University School of Medicine, Indianapolis, IN, USA), Ichiro Ikuta (Department of Radiology, Mayo Clinic Comprehensive Cancer Center, Phoenix, AZ), Fatima Memon (Carolina Radiology, Myrtle Beach, SC, USA), Claudia Kirsch (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Melissa Davis (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Spyridon Bakas (Indiana University School of Medicine, Indianapolis, IN, USA)
Karl-Titus Hoffmann
From the University of Leipzig, Leipzig, Germany (M.V.R., K.L., K.T.F.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (S.C., A.A.); Center for Outcomes Research and Evaluation, Yale School of Medicine, New Haven, CT, USA (S.C., S.A.); Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA (A.A.); Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA (N.M., M.S.A.); Center for Translational Imaging Analysis and Machine Learning, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (T.Z.); Department of Neurosurgery, Heinrich-Heine-University, Moorenstrasse 5, 40225 Duesseldorf, Germany (J.L.); Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, 40225, Dusseldorf, Germany (N.T.); University of Duisburg-Essen, 45147 Essen, Germany (L.J.); DKFZ Division of Translational Neuro-oncology at the WTZ, German Cancer Consortium, DKTK Partner Site, University Hospital Essen, 45147 Essen, Germany (L.J.); University of Ulm, Ulm, Germany (S.M.); Visage Imaging, Inc., San Diego, CA, USA (M.D.L); Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA (S.A.); IBSR consortium: Manpreet Kaur (Ludwig Maximilian University, Munich, Germany), Divya Ramakrishnan (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Khaled Bousabarah (Visage Imaging GmbH, Berlin, Germany), Nicolas Linder (University of Leipzig, Leipzig, Germany), Sarah M. Jacobs (Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands), Francesca Conti (Università di Roma -La Sapienza), Gabriel Cassinelli Petersen (University of Göttingen, Göttingen, Germany), Ujjwal Baid (Indiana University School of Medicine, Indianapolis, IN, USA), Ichiro Ikuta (Department of Radiology, Mayo Clinic Comprehensive Cancer Center, Phoenix, AZ), Fatima Memon (Carolina Radiology, Myrtle Beach, SC, USA), Claudia Kirsch (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Melissa Davis (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Spyridon Bakas (Indiana University School of Medicine, Indianapolis, IN, USA)
Sanjay Aneja
From the University of Leipzig, Leipzig, Germany (M.V.R., K.L., K.T.F.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (S.C., A.A.); Center for Outcomes Research and Evaluation, Yale School of Medicine, New Haven, CT, USA (S.C., S.A.); Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA (A.A.); Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA (N.M., M.S.A.); Center for Translational Imaging Analysis and Machine Learning, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (T.Z.); Department of Neurosurgery, Heinrich-Heine-University, Moorenstrasse 5, 40225 Duesseldorf, Germany (J.L.); Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, 40225, Dusseldorf, Germany (N.T.); University of Duisburg-Essen, 45147 Essen, Germany (L.J.); DKFZ Division of Translational Neuro-oncology at the WTZ, German Cancer Consortium, DKTK Partner Site, University Hospital Essen, 45147 Essen, Germany (L.J.); University of Ulm, Ulm, Germany (S.M.); Visage Imaging, Inc., San Diego, CA, USA (M.D.L); Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA (S.A.); IBSR consortium: Manpreet Kaur (Ludwig Maximilian University, Munich, Germany), Divya Ramakrishnan (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Khaled Bousabarah (Visage Imaging GmbH, Berlin, Germany), Nicolas Linder (University of Leipzig, Leipzig, Germany), Sarah M. Jacobs (Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands), Francesca Conti (Università di Roma -La Sapienza), Gabriel Cassinelli Petersen (University of Göttingen, Göttingen, Germany), Ujjwal Baid (Indiana University School of Medicine, Indianapolis, IN, USA), Ichiro Ikuta (Department of Radiology, Mayo Clinic Comprehensive Cancer Center, Phoenix, AZ), Fatima Memon (Carolina Radiology, Myrtle Beach, SC, USA), Claudia Kirsch (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Melissa Davis (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Spyridon Bakas (Indiana University School of Medicine, Indianapolis, IN, USA)
Mariam S. Aboian
From the University of Leipzig, Leipzig, Germany (M.V.R., K.L., K.T.F.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (S.C., A.A.); Center for Outcomes Research and Evaluation, Yale School of Medicine, New Haven, CT, USA (S.C., S.A.); Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA (A.A.); Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA (N.M., M.S.A.); Center for Translational Imaging Analysis and Machine Learning, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (T.Z.); Department of Neurosurgery, Heinrich-Heine-University, Moorenstrasse 5, 40225 Duesseldorf, Germany (J.L.); Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, 40225, Dusseldorf, Germany (N.T.); University of Duisburg-Essen, 45147 Essen, Germany (L.J.); DKFZ Division of Translational Neuro-oncology at the WTZ, German Cancer Consortium, DKTK Partner Site, University Hospital Essen, 45147 Essen, Germany (L.J.); University of Ulm, Ulm, Germany (S.M.); Visage Imaging, Inc., San Diego, CA, USA (M.D.L); Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA (S.A.); IBSR consortium: Manpreet Kaur (Ludwig Maximilian University, Munich, Germany), Divya Ramakrishnan (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Khaled Bousabarah (Visage Imaging GmbH, Berlin, Germany), Nicolas Linder (University of Leipzig, Leipzig, Germany), Sarah M. Jacobs (Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands), Francesca Conti (Università di Roma -La Sapienza), Gabriel Cassinelli Petersen (University of Göttingen, Göttingen, Germany), Ujjwal Baid (Indiana University School of Medicine, Indianapolis, IN, USA), Ichiro Ikuta (Department of Radiology, Mayo Clinic Comprehensive Cancer Center, Phoenix, AZ), Fatima Memon (Carolina Radiology, Myrtle Beach, SC, USA), Claudia Kirsch (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Melissa Davis (Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA), Spyridon Bakas (Indiana University School of Medicine, Indianapolis, IN, USA)
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Accepted Manuscript
Marc von Reppert, Saahil Chadha, Klara Willms, Arman Avesta, Nazanin Maleki, Tal Zeevi, Jan Lost, Niklas Tillmanns, Leon Jekel, Sara Merkaj, IBSR Consortium, MingDe Lin, Karl-Titus Hoffmann, Sanjay Aneja, Mariam S. Aboian
Image-Based Search in Radiology: Identification of Brain Tumor Subtypes within Databases using MRI-Based Radiomic Features
American Journal of Neuroradiology Apr 2025, ajnr.A8805; DOI: 10.3174/ajnr.A8805
Accepted Manuscript
Image-Based Search in Radiology: Identification of Brain Tumor Subtypes within Databases using MRI-Based Radiomic Features
Marc von Reppert, Saahil Chadha, Klara Willms, Arman Avesta, Nazanin Maleki, Tal Zeevi, Jan Lost, Niklas Tillmanns, Leon Jekel, Sara Merkaj, IBSR Consortium, MingDe Lin, Karl-Titus Hoffmann, Sanjay Aneja, Mariam S. Aboian
American Journal of Neuroradiology Apr 2025, ajnr.A8805; DOI: 10.3174/ajnr.A8805
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