Research ArticleORIGINAL RESEARCH
Implications of Hydrocephalus on [18F]-Fluorodeoxyglucose Positron Emission Tomography Statistical Parametric Mapping Analysis in Neurodegenerative Disease Evaluation
Andres Ricaurte-Fajardo, Ana M. Franceschi, Debra D’ Angelo, Aliah McCalla, Miran Salgado, Moath Hamed, Brielle Intorcia, Carlyn Wisherop, Samantha A. Keil, Anna S. Nordvig, Joseph R. Osborne, Gloria C. Chiang and Jana Ivanidze
American Journal of Neuroradiology February 2025, ajnr.A8698; DOI: https://doi.org/10.3174/ajnr.A8698
Andres Ricaurte-Fajardo
From the Department of Radiology (A.R-F, A.M, B.I, C.W, SA.K, JR.O, GC.C, J.I), Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Division of Molecular Imaging and Therapeutics (A.R-F, JR.O, J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Brain Health Imaging Institute (A.R-F, SA.K, AS.N, GC.C and J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Neuroscience, Division of Neurology (A.R-F), Pontificia Universidad Javeriana, Bogota, Colombia; the Department of Radiology (AM.F) Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwel, New York, New York, USA; the Department of Population Health Sciences (D.D) Weill Cornell Medicine, New York, New York, USA; the School of Medicine (A.M) Central Michigan College of Medicine, Saginaw, Michigan, USA; the Department of Neurology (M.S, M.H) New York Presbyterian Brooklyn Methodist Hospital, New York, USA; the Department of Neurology (AS.N) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA
Ana M. Franceschi
From the Department of Radiology (A.R-F, A.M, B.I, C.W, SA.K, JR.O, GC.C, J.I), Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Division of Molecular Imaging and Therapeutics (A.R-F, JR.O, J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Brain Health Imaging Institute (A.R-F, SA.K, AS.N, GC.C and J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Neuroscience, Division of Neurology (A.R-F), Pontificia Universidad Javeriana, Bogota, Colombia; the Department of Radiology (AM.F) Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwel, New York, New York, USA; the Department of Population Health Sciences (D.D) Weill Cornell Medicine, New York, New York, USA; the School of Medicine (A.M) Central Michigan College of Medicine, Saginaw, Michigan, USA; the Department of Neurology (M.S, M.H) New York Presbyterian Brooklyn Methodist Hospital, New York, USA; the Department of Neurology (AS.N) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA
Debra D’ Angelo
From the Department of Radiology (A.R-F, A.M, B.I, C.W, SA.K, JR.O, GC.C, J.I), Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Division of Molecular Imaging and Therapeutics (A.R-F, JR.O, J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Brain Health Imaging Institute (A.R-F, SA.K, AS.N, GC.C and J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Neuroscience, Division of Neurology (A.R-F), Pontificia Universidad Javeriana, Bogota, Colombia; the Department of Radiology (AM.F) Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwel, New York, New York, USA; the Department of Population Health Sciences (D.D) Weill Cornell Medicine, New York, New York, USA; the School of Medicine (A.M) Central Michigan College of Medicine, Saginaw, Michigan, USA; the Department of Neurology (M.S, M.H) New York Presbyterian Brooklyn Methodist Hospital, New York, USA; the Department of Neurology (AS.N) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA
Aliah McCalla
From the Department of Radiology (A.R-F, A.M, B.I, C.W, SA.K, JR.O, GC.C, J.I), Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Division of Molecular Imaging and Therapeutics (A.R-F, JR.O, J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Brain Health Imaging Institute (A.R-F, SA.K, AS.N, GC.C and J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Neuroscience, Division of Neurology (A.R-F), Pontificia Universidad Javeriana, Bogota, Colombia; the Department of Radiology (AM.F) Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwel, New York, New York, USA; the Department of Population Health Sciences (D.D) Weill Cornell Medicine, New York, New York, USA; the School of Medicine (A.M) Central Michigan College of Medicine, Saginaw, Michigan, USA; the Department of Neurology (M.S, M.H) New York Presbyterian Brooklyn Methodist Hospital, New York, USA; the Department of Neurology (AS.N) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA
Miran Salgado
From the Department of Radiology (A.R-F, A.M, B.I, C.W, SA.K, JR.O, GC.C, J.I), Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Division of Molecular Imaging and Therapeutics (A.R-F, JR.O, J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Brain Health Imaging Institute (A.R-F, SA.K, AS.N, GC.C and J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Neuroscience, Division of Neurology (A.R-F), Pontificia Universidad Javeriana, Bogota, Colombia; the Department of Radiology (AM.F) Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwel, New York, New York, USA; the Department of Population Health Sciences (D.D) Weill Cornell Medicine, New York, New York, USA; the School of Medicine (A.M) Central Michigan College of Medicine, Saginaw, Michigan, USA; the Department of Neurology (M.S, M.H) New York Presbyterian Brooklyn Methodist Hospital, New York, USA; the Department of Neurology (AS.N) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA
Moath Hamed
From the Department of Radiology (A.R-F, A.M, B.I, C.W, SA.K, JR.O, GC.C, J.I), Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Division of Molecular Imaging and Therapeutics (A.R-F, JR.O, J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Brain Health Imaging Institute (A.R-F, SA.K, AS.N, GC.C and J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Neuroscience, Division of Neurology (A.R-F), Pontificia Universidad Javeriana, Bogota, Colombia; the Department of Radiology (AM.F) Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwel, New York, New York, USA; the Department of Population Health Sciences (D.D) Weill Cornell Medicine, New York, New York, USA; the School of Medicine (A.M) Central Michigan College of Medicine, Saginaw, Michigan, USA; the Department of Neurology (M.S, M.H) New York Presbyterian Brooklyn Methodist Hospital, New York, USA; the Department of Neurology (AS.N) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA
Brielle Intorcia
From the Department of Radiology (A.R-F, A.M, B.I, C.W, SA.K, JR.O, GC.C, J.I), Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Division of Molecular Imaging and Therapeutics (A.R-F, JR.O, J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Brain Health Imaging Institute (A.R-F, SA.K, AS.N, GC.C and J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Neuroscience, Division of Neurology (A.R-F), Pontificia Universidad Javeriana, Bogota, Colombia; the Department of Radiology (AM.F) Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwel, New York, New York, USA; the Department of Population Health Sciences (D.D) Weill Cornell Medicine, New York, New York, USA; the School of Medicine (A.M) Central Michigan College of Medicine, Saginaw, Michigan, USA; the Department of Neurology (M.S, M.H) New York Presbyterian Brooklyn Methodist Hospital, New York, USA; the Department of Neurology (AS.N) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA
Carlyn Wisherop
From the Department of Radiology (A.R-F, A.M, B.I, C.W, SA.K, JR.O, GC.C, J.I), Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Division of Molecular Imaging and Therapeutics (A.R-F, JR.O, J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Brain Health Imaging Institute (A.R-F, SA.K, AS.N, GC.C and J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Neuroscience, Division of Neurology (A.R-F), Pontificia Universidad Javeriana, Bogota, Colombia; the Department of Radiology (AM.F) Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwel, New York, New York, USA; the Department of Population Health Sciences (D.D) Weill Cornell Medicine, New York, New York, USA; the School of Medicine (A.M) Central Michigan College of Medicine, Saginaw, Michigan, USA; the Department of Neurology (M.S, M.H) New York Presbyterian Brooklyn Methodist Hospital, New York, USA; the Department of Neurology (AS.N) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA
Samantha A. Keil
From the Department of Radiology (A.R-F, A.M, B.I, C.W, SA.K, JR.O, GC.C, J.I), Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Division of Molecular Imaging and Therapeutics (A.R-F, JR.O, J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Brain Health Imaging Institute (A.R-F, SA.K, AS.N, GC.C and J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Neuroscience, Division of Neurology (A.R-F), Pontificia Universidad Javeriana, Bogota, Colombia; the Department of Radiology (AM.F) Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwel, New York, New York, USA; the Department of Population Health Sciences (D.D) Weill Cornell Medicine, New York, New York, USA; the School of Medicine (A.M) Central Michigan College of Medicine, Saginaw, Michigan, USA; the Department of Neurology (M.S, M.H) New York Presbyterian Brooklyn Methodist Hospital, New York, USA; the Department of Neurology (AS.N) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA
Anna S. Nordvig
From the Department of Radiology (A.R-F, A.M, B.I, C.W, SA.K, JR.O, GC.C, J.I), Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Division of Molecular Imaging and Therapeutics (A.R-F, JR.O, J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Brain Health Imaging Institute (A.R-F, SA.K, AS.N, GC.C and J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Neuroscience, Division of Neurology (A.R-F), Pontificia Universidad Javeriana, Bogota, Colombia; the Department of Radiology (AM.F) Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwel, New York, New York, USA; the Department of Population Health Sciences (D.D) Weill Cornell Medicine, New York, New York, USA; the School of Medicine (A.M) Central Michigan College of Medicine, Saginaw, Michigan, USA; the Department of Neurology (M.S, M.H) New York Presbyterian Brooklyn Methodist Hospital, New York, USA; the Department of Neurology (AS.N) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA
Joseph R. Osborne
From the Department of Radiology (A.R-F, A.M, B.I, C.W, SA.K, JR.O, GC.C, J.I), Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Division of Molecular Imaging and Therapeutics (A.R-F, JR.O, J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Brain Health Imaging Institute (A.R-F, SA.K, AS.N, GC.C and J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Neuroscience, Division of Neurology (A.R-F), Pontificia Universidad Javeriana, Bogota, Colombia; the Department of Radiology (AM.F) Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwel, New York, New York, USA; the Department of Population Health Sciences (D.D) Weill Cornell Medicine, New York, New York, USA; the School of Medicine (A.M) Central Michigan College of Medicine, Saginaw, Michigan, USA; the Department of Neurology (M.S, M.H) New York Presbyterian Brooklyn Methodist Hospital, New York, USA; the Department of Neurology (AS.N) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA
Gloria C. Chiang
From the Department of Radiology (A.R-F, A.M, B.I, C.W, SA.K, JR.O, GC.C, J.I), Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Division of Molecular Imaging and Therapeutics (A.R-F, JR.O, J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Brain Health Imaging Institute (A.R-F, SA.K, AS.N, GC.C and J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Neuroscience, Division of Neurology (A.R-F), Pontificia Universidad Javeriana, Bogota, Colombia; the Department of Radiology (AM.F) Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwel, New York, New York, USA; the Department of Population Health Sciences (D.D) Weill Cornell Medicine, New York, New York, USA; the School of Medicine (A.M) Central Michigan College of Medicine, Saginaw, Michigan, USA; the Department of Neurology (M.S, M.H) New York Presbyterian Brooklyn Methodist Hospital, New York, USA; the Department of Neurology (AS.N) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA
Jana Ivanidze
From the Department of Radiology (A.R-F, A.M, B.I, C.W, SA.K, JR.O, GC.C, J.I), Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Division of Molecular Imaging and Therapeutics (A.R-F, JR.O, J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Brain Health Imaging Institute (A.R-F, SA.K, AS.N, GC.C and J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Neuroscience, Division of Neurology (A.R-F), Pontificia Universidad Javeriana, Bogota, Colombia; the Department of Radiology (AM.F) Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwel, New York, New York, USA; the Department of Population Health Sciences (D.D) Weill Cornell Medicine, New York, New York, USA; the School of Medicine (A.M) Central Michigan College of Medicine, Saginaw, Michigan, USA; the Department of Neurology (M.S, M.H) New York Presbyterian Brooklyn Methodist Hospital, New York, USA; the Department of Neurology (AS.N) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA

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- Published online February 13, 2025.
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© 2025 by American Journal of Neuroradiology
Author Information
- Andres Ricaurte-Fajardo,
- Ana M. Franceschi,
- Debra D’ Angelo,
- Aliah McCalla,
- Miran Salgado,
- Moath Hamed,
- Brielle Intorcia,
- Carlyn Wisherop,
- Samantha A. Keil,
- Anna S. Nordvig,
- Joseph R. Osborne,
- Gloria C. Chiang and
- Jana Ivanidze
- From the Department of Radiology (A.R-F, A.M, B.I, C.W, SA.K, JR.O, GC.C, J.I), Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Division of Molecular Imaging and Therapeutics (A.R-F, JR.O, J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Radiology, Brain Health Imaging Institute (A.R-F, SA.K, AS.N, GC.C and J.I) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA; the Department of Neuroscience, Division of Neurology (A.R-F), Pontificia Universidad Javeriana, Bogota, Colombia; the Department of Radiology (AM.F) Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwel, New York, New York, USA; the Department of Population Health Sciences (D.D) Weill Cornell Medicine, New York, New York, USA; the School of Medicine (A.M) Central Michigan College of Medicine, Saginaw, Michigan, USA; the Department of Neurology (M.S, M.H) New York Presbyterian Brooklyn Methodist Hospital, New York, USA; the Department of Neurology (AS.N) Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA
- Correspondence to:
Jana Ivanidze, MD, PhD. Department of Radiology, Weill Cornell Medicine, 1300 York Avenue, New York, New York, 10021, USA, jai9018{at}med.cornell.edu
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Accepted Manuscript
Andres Ricaurte-Fajardo, Ana M. Franceschi, Debra D’ Angelo, Aliah McCalla, Miran Salgado, Moath Hamed, Brielle Intorcia, Carlyn Wisherop, Samantha A. Keil, Anna S. Nordvig, Joseph R. Osborne, Gloria C. Chiang, Jana Ivanidze
Implications of Hydrocephalus on [18F]-Fluorodeoxyglucose Positron Emission Tomography Statistical Parametric Mapping Analysis in Neurodegenerative Disease Evaluation
American Journal of Neuroradiology Feb 2025, ajnr.A8698; DOI: 10.3174/ajnr.A8698
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Accepted Manuscript
Implications of Hydrocephalus on [18F]-Fluorodeoxyglucose Positron Emission Tomography Statistical Parametric Mapping Analysis in Neurodegenerative Disease Evaluation
Andres Ricaurte-Fajardo, Ana M. Franceschi, Debra D’ Angelo, Aliah McCalla, Miran Salgado, Moath Hamed, Brielle Intorcia, Carlyn Wisherop, Samantha A. Keil, Anna S. Nordvig, Joseph R. Osborne, Gloria C. Chiang, Jana Ivanidze
American Journal of Neuroradiology Feb 2025, ajnr.A8698; DOI: 10.3174/ajnr.A8698
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