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Research ArticleNeurointervention

Double Stent Retriever Technique for Mechanical Thrombectomy: A Systematic Review and Meta-Analysis

Jeremy Hofmeister, Olivier Brina, Gianmarco Bernava, Andrea Rosi, Philippe Reymond, Karl-Olof Lovblad and Paolo Machi
American Journal of Neuroradiology July 2024, DOI: https://doi.org/10.3174/ajnr.A8253
Jeremy Hofmeister
aFrom the Department of Diagnostics (J.H., O.B., G.B., A.R., P.R., K.-O.L., P.M.), Diagnostic and Interventional Neuroradiology, Geneva University Hospitals, Geneva, Switzerland
bBrain Endovascular Therapeutics Research and Development Lab (J.H., O.B., P.R., K.-O.L., P.M.), Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland
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  • ORCID record for Jeremy Hofmeister
Olivier Brina
aFrom the Department of Diagnostics (J.H., O.B., G.B., A.R., P.R., K.-O.L., P.M.), Diagnostic and Interventional Neuroradiology, Geneva University Hospitals, Geneva, Switzerland
bBrain Endovascular Therapeutics Research and Development Lab (J.H., O.B., P.R., K.-O.L., P.M.), Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland
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Gianmarco Bernava
aFrom the Department of Diagnostics (J.H., O.B., G.B., A.R., P.R., K.-O.L., P.M.), Diagnostic and Interventional Neuroradiology, Geneva University Hospitals, Geneva, Switzerland
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Andrea Rosi
aFrom the Department of Diagnostics (J.H., O.B., G.B., A.R., P.R., K.-O.L., P.M.), Diagnostic and Interventional Neuroradiology, Geneva University Hospitals, Geneva, Switzerland
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Philippe Reymond
aFrom the Department of Diagnostics (J.H., O.B., G.B., A.R., P.R., K.-O.L., P.M.), Diagnostic and Interventional Neuroradiology, Geneva University Hospitals, Geneva, Switzerland
bBrain Endovascular Therapeutics Research and Development Lab (J.H., O.B., P.R., K.-O.L., P.M.), Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland
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Karl-Olof Lovblad
aFrom the Department of Diagnostics (J.H., O.B., G.B., A.R., P.R., K.-O.L., P.M.), Diagnostic and Interventional Neuroradiology, Geneva University Hospitals, Geneva, Switzerland
bBrain Endovascular Therapeutics Research and Development Lab (J.H., O.B., P.R., K.-O.L., P.M.), Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland
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Paolo Machi
aFrom the Department of Diagnostics (J.H., O.B., G.B., A.R., P.R., K.-O.L., P.M.), Diagnostic and Interventional Neuroradiology, Geneva University Hospitals, Geneva, Switzerland
bBrain Endovascular Therapeutics Research and Development Lab (J.H., O.B., P.R., K.-O.L., P.M.), Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland
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  • FIG 1.
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    FIG 1.

    Illustration of the parallel and stent-in-stent DSR techniques. A, Navigation of the first microcatheter over a microwire distal to the clot (step common to both DSR techniques), as in conventional thrombectomy using an SSR. Deployment of the stent retrievers (3 different steps between the parallel and stent-in-stent DSR techniques). B, In the parallel DSR technique, B1, A second microcatheter is navigated distal to the clot on a microwire, ideally in an arterial branch different from the first microcatheter. B2, The first SR is deployed distally and through the clot. As with the MT SSR, the clot should be in the proximal part of the SR. B3, The second SR is deployed, ideally with the clot also in the proximal part of the SR. C, In the stent-in-stent technique, C1, The first SR is deployed distally and through the clot, ideally with a clot in the proximal part of the SR. C2, A second microcatheter is navigated distal to the clot over a microwire through the mesh of the first stent, ideally into an arterial branch different from the one used for the first microcatheter. C3, The second SR is deployed, ideally with the clot also in the proximal part of the SR. D, Removal of the 2 SRs together (common to both DSR techniques). Both SRs are removed at the same time and at the same slow speed. To ensure that the removal of both SRs begins at the same time, it is important to tension both stents before retrieval. It may also be useful to place a single torque on the pushwires of both stents once they have been tensioned, to remove the stents at an identical and harmonious speed.

  • FIG 2.
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    FIG 2.

    Efficacy of DSR MT. A, Successful recanalization (mTICI ≥ 2b). B, FPE.

  • FIG 3.
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    FIG 3.

    Efficacy of DSR MT in large cohorts only (n = 6): A, Successful recanalization (mTICI ≥ 2b). B, FPE.

  • FIG 4.
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    FIG 4.

    Safety of DSR MT dissections (A) and SAH (B).

  • FIG 5.
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    FIG 5.

    Symptomatic and asymptomatic intracranial hemorrhage. A, AICH in all studies. B, SICH in all studies. C, AICH in large cohorts only. D, SICH in large cohorts only. ICH indicates intracranial hemorrhage.

  • FIG 6.
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    FIG 6.

    Safety of DSR MT in large-cohort studies only (n = 6): dissections (A) and SAH (B).

Tables

  • Figures
  • Estimated prevalence of successful recanalization (mTICI ≥2b) and FPE following DSR, as well as complications due to dissection, SAH, AICH, and SICH

    Prevalence (95% CI)Heterogeneity I2Wld (P Value)
    Estimated prevalence for all studies (n = 17)
     FPE76.56% [68.46–83.10]0%2.35 (P = 1.0)
     mTICI ≥ 2b92.60% [82.43–97.01]26.42%0.31 (P = 1.0)
     Dissection0.37% [0–44.50]65.90%0.0 (P = 1.0)
     SAH1.56% [0.39–6.03]0%0.97 (P = 1.0)
     AICH8.05% [3.14–19.14]33.58%0.55 (P = 1.0)
     SICH5.47% [2.63–11.03]0%0.86 (P = 1.0)
    Estimated prevalence for large studies only (n= 6)
     FPE75.0% [66.34–82.04]0%1.79 (P = .877)
     mTICI ≥ 2b91.05% [80.04–96.27]44.39%0.31 (P = .998)
     Dissection0.42% [0–58.34]75.96%0.0 (P = 1.0)
     SAH1.72% [0.43–6.63]0%0.97 (P = .965)
     AICH8.37% [3.13–20.55]50.0%0.55 (P = .990)
     SICH6.03% [2.90–12.12]0%0.85 (P = .973)
    • Note:—Wld indicates Wald-type test statistic of the test for (residual) heterogeneity.

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Double Stent Retriever Technique for Mechanical Thrombectomy: A Systematic Review and Meta-Analysis
Jeremy Hofmeister, Olivier Brina, Gianmarco Bernava, Andrea Rosi, Philippe Reymond, Karl-Olof Lovblad, Paolo Machi
American Journal of Neuroradiology Jul 2024, DOI: 10.3174/ajnr.A8253
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Cite this article
Jeremy Hofmeister, Olivier Brina, Gianmarco Bernava, Andrea Rosi, Philippe Reymond, Karl-Olof Lovblad, Paolo Machi
Double Stent Retriever Technique for Mechanical Thrombectomy: A Systematic Review and Meta-Analysis
American Journal of Neuroradiology Jul 2024, DOI: 10.3174/ajnr.A8253

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