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Research ArticleULTRA-HIGH-FIELD MRI/IMAGING OF EPILEPSY/DEMYELINATING DISEASES/INFLAMMATION/INFECTION

Comparison of a Whole-Brain Contrast-Enhanced 3D TSE T1WI versus Orbits Contrast-Enhanced 2D Coronal T1WI at 3T MRI for the Detection of Optic Nerve Enhancement in Patients with Acute Loss of Visual Acuity

David Prillard, Frédérique Charbonneau, Pierre Clavel, Catherine Vignal-Clermont, Romain Deschamps, Marine Boudot de la Motte, Jessica Guillaume, Julien Savatovsky and Augustin Lecler
American Journal of Neuroradiology June 2024, DOI: https://doi.org/10.3174/ajnr.A8233
David Prillard
aFrom the Department of Neuroradiology (D.P., F.C., P.C., J.S., A.L.), A. Rothschild Foundation Hospital, Paris, France
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  • ORCID record for David Prillard
Frédérique Charbonneau
aFrom the Department of Neuroradiology (D.P., F.C., P.C., J.S., A.L.), A. Rothschild Foundation Hospital, Paris, France
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  • ORCID record for Frédérique Charbonneau
Pierre Clavel
aFrom the Department of Neuroradiology (D.P., F.C., P.C., J.S., A.L.), A. Rothschild Foundation Hospital, Paris, France
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Catherine Vignal-Clermont
bDepartment of Ophthalmology (C.V.-C.), A. Rothschild Foundation Hospital, Paris, France
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Romain Deschamps
cDepartment of Neurology (R.D., M.B.d.l.M.), A. Rothschild Foundation Hospital, Paris, France
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Marine Boudot de la Motte
cDepartment of Neurology (R.D., M.B.d.l.M.), A. Rothschild Foundation Hospital, Paris, France
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Jessica Guillaume
dDepartment of Clinical Research (J.G.), A. Rothschild Foundation Hospital, Paris, France
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Julien Savatovsky
aFrom the Department of Neuroradiology (D.P., F.C., P.C., J.S., A.L.), A. Rothschild Foundation Hospital, Paris, France
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Augustin Lecler
aFrom the Department of Neuroradiology (D.P., F.C., P.C., J.S., A.L.), A. Rothschild Foundation Hospital, Paris, France
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  • FIG 1.
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    FIG 1.

    A 21-year-old woman presenting with acute vision loss and orbital pain of the right eye. WBCE-3D TSE T1WI reformatted in the coronal plane (A) shows enhancement of the intraorbital segment of the right optic nerve at the orbital apex (white arrow), whereas no optic nerve enhancement was detected on OCE-2D coronal T1WI (black arrow) (B). The WBCE-3D T1WI sequence reformatted in the axial (C) and sagittal (D) planes confirming and precisely localizing the enhancement of the optic nerve.

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    FIG 2.

    A 27-year-old woman presenting with acute vision loss and orbital pain of the right eye. OCE-2D coronal T1WI (A) shows enhancement of the intraorbital segment of the right optic nerve (arrow), also seen on the WBCE-3D TSE T1WI reformatted in the coronal (B), axial (C), and sagittal (D) planes.

  • FIG 3.
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    FIG 3.

    A 53-year-old woman presenting with acute vision loss of the right eye. WBCE-3D TSE T1WI reformatted in the axial plane (A) shows enhancement of the right optic disc (arrowhead). The WBCE-3D T1WI sequence reformatted in the sagittal plane (B), confirming the enhancement. No enhancement was detected on OCE-2D coronal T1WI (C).

Tables

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    Table 1:

    Detailed MR imaging acquisition parameters of OCE-2D coronal T1WI and WBCE-3D TSE T1WI

    MR Imaging SequenceOCE-2D T1WIWBCE-3D T1WI
    Sequence typeTSETSE
    Acquisition mode2D3D
    Acquisition planeCoronalSagittal
    TR (ms)400500
    TE (ms)1226
    Section thickness (mm)31
    GapNoNo
    No. of excitations11
    Echo-train length120
    Flip angle90°90°
    Bandwidth (Hz)218288
    Matrix232 × 224252 × 252 × 400
    Field of view (mm)140 × 140252 × 252 × 200
    Acquired voxel size (mm)0.6 × 0.6 × 31 × 1 × 1
    Reconstructed voxel size (mm)0.16 × 0.16 × 30.49 × 0.49 × 0.50
    Acquisition time (min)04:2203:37
    • View popup
    Table 2:

    Comparison of WBCE-3D TSE T1WI and OCE-2D coronal T1WI

    OCE-2D T1WI (n = 1023) (%)WBCE-3D T1WI (n = 1023) (%)P Value
    Optic nerve enhancement205/1023 (20)245/1023 (24)<.001a
    Localization of the enhancement
     Bilateral14/1023 (1.4)23/1023 (2.2).05
     Intraorbital138/1023 (13.5)151/1023 (14.8)<.4
     Canalicular90/1023 (8.8)108/1023 (10.6).04a
     Cisternal38/1023 (3.7)27/1023 (2.6).09
     Optic chiasm9/1023 (0.9)10/1023 (1.0)>.9
     Optic disc0/1023 (0.0)27/1023 (2.6)NA
    Artifacts
     None562/1023 (55.0)853/1023 (83.4)P < .001a
     Moderate360/1023 (35.2)102/1023 (10.0)
     Severe101/1023 (9.8)68/1023 (6.6)
    Reader-reported confidence
     136/1023 (3.5)314/1023 (30.7)P < .001a
     228/1023 (2.7)194/1023 (19.0)
     399/1023 (9.7)236/1023 (23.1)
     4269/1023 (26.3)188/1023 (18.4)
     5591/1023 (57.8)91/1023 (8.9)
    • Note:— NA indicates not applicable.

    • a Statistically significant difference.

    • View popup
    Table 3:

    Inter- and intraobserver agreement for a WBCE-3D TSE T1WI and OCE-2D coronal T1WI when detecting optic nerve or optic chiasm enhancement

    InterobserverIntraobserver
    OCE-2D T1WI κ (95% CI)WBCE-3D T1WI κ (95% CI)OCE-2D T1WI κ (95% CI)WBCE-3D T1WI κ (95% CI)
    Optic nerve enhancement0.80 (0.75–0.85)0.65 (0.60–0.71)0.75 (0.70–0.80)1 (1–1)
    Localization of the enhancement
     Bilateral0.90 (0.78–1)0.53 (0.34–0.71)0.75 (0.58–0.92)1 (1–1)
     Intraorbital segment0.76 (0.70–0.82)0.63 (0.57–0.70)0.81 (0.76–0.87)0.81 (0.76–0.87)
     Canalicular segment0.64 (0.56–0.73)0.72 (0.65–0.79)0.71 (0.64–0.79)0.68 (0.58–0.75)
     Cisternal segment0.58 (0.45–0.72)0.54 (0.37–0.72)0.49 (0.34–0.65)0.81 (0.76–0.87)
     Optic chiasm0.44 (0.15–0.73)0.73 (0.51–0.96)0.33 (0.04–0.61)1 (1–1)
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Comparison of a Whole-Brain Contrast-Enhanced 3D TSE T1WI versus Orbits Contrast-Enhanced 2D Coronal T1WI at 3T MRI for the Detection of Optic Nerve Enhancement in Patients with Acute Loss of Visual Acuity
David Prillard, Frédérique Charbonneau, Pierre Clavel, Catherine Vignal-Clermont, Romain Deschamps, Marine Boudot de la Motte, Jessica Guillaume, Julien Savatovsky, Augustin Lecler
American Journal of Neuroradiology Jun 2024, DOI: 10.3174/ajnr.A8233
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Comparison of a Whole-Brain Contrast-Enhanced 3D TSE T1WI versus Orbits Contrast-Enhanced 2D Coronal T1WI at 3T MRI for the Detection of Optic Nerve Enhancement in Patients with Acute Loss of Visual Acuity
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David Prillard, Frédérique Charbonneau, Pierre Clavel, Catherine Vignal-Clermont, Romain Deschamps, Marine Boudot de la Motte, Jessica Guillaume, Julien Savatovsky, Augustin Lecler
Comparison of a Whole-Brain Contrast-Enhanced 3D TSE T1WI versus Orbits Contrast-Enhanced 2D Coronal T1WI at 3T MRI for the Detection of Optic Nerve Enhancement in Patients with Acute Loss of Visual Acuity
American Journal of Neuroradiology Jun 2024, DOI: 10.3174/ajnr.A8233

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