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Research ArticleSPINE IMAGING AND SPINE IMAGE-GUIDED INTERVENTION

Lateral Spinal CSF Leaks in Patients with Spontaneous Intracranial Hypotension: Radiologic-Anatomic Study of Different Variants

Wouter I. Schievink, Marcel M. Maya, Angelique Sao-Mai S. Tay, Rachelle B. Taché, Ravi S. Prasad, Vikram Wadhwa and Miriam Nuño
American Journal of Neuroradiology June 2024, DOI: https://doi.org/10.3174/ajnr.A8261
Wouter I. Schievink
aFrom the Department of Neurosurgery (W.I.S., M.M.M., A.S.-M., S.T., R.B.T., R.S.P., V.W.), Cedars-Sinai Medical Center, Los Angeles, California
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  • ORCID record for Wouter I. Schievink
Marcel M. Maya
aFrom the Department of Neurosurgery (W.I.S., M.M.M., A.S.-M., S.T., R.B.T., R.S.P., V.W.), Cedars-Sinai Medical Center, Los Angeles, California
bDepartment of Imaging (M.M.M., R.S.P., V.W.), Cedars-Sinai Medical Center, Los Angeles, California
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Angelique Sao-Mai S. Tay
aFrom the Department of Neurosurgery (W.I.S., M.M.M., A.S.-M., S.T., R.B.T., R.S.P., V.W.), Cedars-Sinai Medical Center, Los Angeles, California
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Rachelle B. Taché
aFrom the Department of Neurosurgery (W.I.S., M.M.M., A.S.-M., S.T., R.B.T., R.S.P., V.W.), Cedars-Sinai Medical Center, Los Angeles, California
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Ravi S. Prasad
aFrom the Department of Neurosurgery (W.I.S., M.M.M., A.S.-M., S.T., R.B.T., R.S.P., V.W.), Cedars-Sinai Medical Center, Los Angeles, California
bDepartment of Imaging (M.M.M., R.S.P., V.W.), Cedars-Sinai Medical Center, Los Angeles, California
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Vikram Wadhwa
aFrom the Department of Neurosurgery (W.I.S., M.M.M., A.S.-M., S.T., R.B.T., R.S.P., V.W.), Cedars-Sinai Medical Center, Los Angeles, California
bDepartment of Imaging (M.M.M., R.S.P., V.W.), Cedars-Sinai Medical Center, Los Angeles, California
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Miriam Nuño
cDepartment of Public Health Sciences (M.N.), University of California, Davis, California
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  • FIG 1.
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    FIG 1.

    Illustration depicting the 3 variants of spontaneous lateral spinal CSF leaks. We found spontaneous lateral CSF leaks to be associated with the axilla of the nerve root sleeve in about two-thirds of patients and associated with the shoulder of the nerve root sleeve in about one-fourth of patients. Uncommonly (7.5%), the lateral dural tear was found at the level of the pedicle and was not associated with the nerve root sleeve.

  • FIG 2.
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    FIG 2.

    Imaging and intraoperative findings of spontaneous lateral spinal CSF leaks arising from the axilla of the nerve root sleeve. DSMs (A and B) show a lateral CSF leak (arrow) arising caudal to the nerve root sleeve (arrowhead). C, Intraoperative photograph shows a lateral dural tear (arrowheads) caudal to the take-off of the nerve root sleeve with arachnoid (asterisk) protruding through the dural tear.

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    FIG 3.

    Imaging and intraoperative findings of spontaneous lateral spinal CSF leaks arising from the shoulder of the nerve root sleeve. DSMs (A and B) show a lateral CSF leak (arrow) arising cranial to the nerve root sleeve (arrowhead). C, Intraoperative photograph shows a lateral dural tear (arrowheads) cranial to the take-off of the nerve root sleeve after the arachnoid membrane has been resected, leaving a clear view of the extended extradural space (asterisk).

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    FIG 4.

    Imaging and intraoperative findings of spontaneous lateral spinal CSF leaks arising at the level of the pedicle. DSM (A) shows a small, defined lateral extradural CSF collection (arrow) at the level of the pedicle, not associated with the nerve root sleeve. Axial T2-weighted MRI (B) shows a corresponding small extradural CSF collection (arrow) that was not visible on post-DSM CT (C). The intrathecal contrast on the post-DSM CT is faint, possibly limiting the sensitivity of leak detection. Intraoperative photograph (D) shows a lateral dural tear (arrowheads) with arachnoid billowing out (asterisk) through the dural defect. DSMs (E–G) show a lateral dural tear (arrow) at the level of the pedicle, not associated with the nerve root sleeve, resulting in an extensive CSF leak, with CSF spreading in both cranial and caudal directions (arrowheads). Intraoperative photographs (H and I) show a linear dural tear (arrowheads) without arachnoid protruding through the dural tear. The underlying spinal cord is visible after spreading the dural tear (H).

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    Table 1:

    Cohort demographics and clinical characteristics (N = 53)

    VariablesNo. (%)
    Age at onset of symptoms (yr)
     Mean (SD)35.5 (10.8)
     Range12–76
    Sex
     Male16 (30.2)
     Female37 (69.8)
    Symptom duration (mo)
     Mean (SD)35.8 (49.7)
     Range0–205
    CSF leak type
     Axilla of nerve root sleeve36 (67.9)
     Pedicle4 (7.6)
     Shoulder of nerve root sleeve13 (24.5)
    CSF leak sidea
     Left27 (46.6)
     Right31 (53.4)
    CSF leak levela
     Cervical3 (5.7)
     Thoracic 4–64 (7.8)
     Thoracic 7–913 (24.5)
     Thoracic 10–1231 (58.5)
     Lumbar2 (3.8)
    • ↵a From a total of 58 CSF leak sites.

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    Table 2:

    Characteristics per leak type

    VariablesCSF Leak Type
    Axilla 36 (67.9%)Pedicle 4 (7.6%)Shoulder 13 (24.5%) P Value
    Age at onset of symptoms (yr).0295
     Mean (SD)38.1 (10.2)32.8 (12.8)28.9 (9.3)
     Minimum-maximum20–7614–4312–43
    Sex
     Male11 (30.6)1 (25.0)4 (30.8)1.0000
     Female25 (69.4)3 (75.0)9 (69.2)
    Symptom duration (mo).7359
     Mean (SD)34.8 (48.4)47.8 (45.7)35.2 (57.7)
     Range1–2050–1060–195 
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Cite this article
Wouter I. Schievink, Marcel M. Maya, Angelique Sao-Mai S. Tay, Rachelle B. Taché, Ravi S. Prasad, Vikram Wadhwa, Miriam Nuño
Lateral Spinal CSF Leaks in Patients with Spontaneous Intracranial Hypotension: Radiologic-Anatomic Study of Different Variants
American Journal of Neuroradiology Jun 2024, DOI: 10.3174/ajnr.A8261

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Lateral Spinal CSF Leaks in Patients with Spontaneous Intracranial Hypotension: Radiologic-Anatomic Study of Different Variants
Wouter I. Schievink, Marcel M. Maya, Angelique Sao-Mai S. Tay, Rachelle B. Taché, Ravi S. Prasad, Vikram Wadhwa, Miriam Nuño
American Journal of Neuroradiology Jun 2024, DOI: 10.3174/ajnr.A8261
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