Article Figures & Data
Figures
- FIG 1.
Example of target artery and PED diameter measurements before (A–C) and after (D–F) treatment. The immediate post-Rx DSA measurements (C) were not used for analysis. They are, however, indicative of the degree of procedure-related vasospasm. The PED is larger in diameter on follow-up (E) compared with immediately after implantation (B), despite a lack of vasospasm when C is compared with A. The expansion of PED in E compared with B is due to outward remodeling, which counteracts the endothelialization-driven decrease in follow-up vessel diameter (F). Rx indicates treatment.
- FIG 2.
Distribution of NIO thickness on follow-up imaging. There is no statistical indication that subjects with greater NIO thickness represent a different population; there is no second peak. It is not clear if substantially larger samples would change this assessment.
- FIG 3.
Distribution of percentage change in target artery diameter compared with the pretreatment baseline. Most vessels are smaller in diameter, while a few are larger. The final diameter is governed by opposing factors of endothelialization and outward remodeling.
- FIG 4.
PED oversizing relative to target artery versus percentage change in target artery diameter on follow-up DSA. There is an extremely robust (R2 = 0.98) linear relationship. Oversizing allows the vessel to expand (outward remodeling), thus mitigating an endothelialization-related decrease in vessel diameter. To what extent remodeling is influenced by device or construct radial force is unclear. The observation that single and double PED constructs behave similarly may suggest that radial force is not a major factor for PEDs in this range. However, possible differences may exist when baseline arterial diameter is considered by analyzing percentage PED oversize rather than absolute value (Online Supplemental Data). All findings are applicable to the PED only.
Tables
Baseline demographic characteristics and treatment results
Parameter No. SD Age 54 14 Female sex 81 Petrous 1 Cavernous 6 Paraophthalmic/paraclinoid 66 PcomA 7 Anterior choroidal 3 MCA 3 A1 1 AcomA 7 Pericallosal 2 PICA 2 Basilar 2 Fusiform aneurysms, No. 3 Smokers 27 Discharge PRU, average 84 59 Aneurysm size, average (mm) 5 2 No. of PEDs, average 1.7 0.7 Follow-up length, average (mo) 9 3 No. complete occlusions 87 Neointimal thickness, overall (mm) 0.3 0.1 Neointimal thickness, 1 PED construct (n = 48) (mm) 0.3 0.1 Neointimal thickness, 2 PED constructs (n = 39) (mm) 0.3 0.1 Neointimal thickness, 3+ PED constructs (n = 13) (mm) 0.3 0.1 Increase in PED diameter post-Rx (mm) 0.14 0.2 Percentage change in target vessel diameter, pre-/post-Rx −15 10 Note:—PcomA indicates posterior communicating artery; AcomA, anterior communicating artery; Rx, treatment.
