Cortical Hyperperfusion on MRI Arterial Spin-Labeling during the Interictal Period of Patients with Migraine Headache

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FIG 1.
Values of rCBF during the interictal period in patients with migraine with/without insomnia. These plots are graphical representations of the data presented in the Table. In bar graphs of mean rCBF, black bars indicate migraine without insomnia, dotted bars indicate migraine with insomnia, and white bars indicate healthy controls. THA indicates rCBF in the territory of the thalamus; AM, anterior part of the territory of the MCA; PM, posterior part of the territory of the MCA.
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FIG 2.
Findings from MR imaging ASL. A, Typical CHP findings in a 41-year-old woman with episodic migraine without insomnia. B and C, Normal findings without CHP in a 48-year-old woman with chronic migraine complicated by insomnia (B) and a 30-year-old woman from the healthy control group (C).

Comparison of CBF using MR imaging of ASL in control subjects and patients with migraine with and without insomnia and/or depression^a

	Cases	ACA	AM	PM	PCA	Tha
Healthy control	26	48 (SD, 6)^b	49 (SD, 7)^b	48 (SD, 6)^b	47 (SD, 6)^b	45 (SD, 6)^b
Baseline for hyperperfusion		60	63	60	59	57
Migraine without insomnia	97	62 (SD, 6)	64 (SD, 5)	63 (SD, 5)	61 (SD, 5)	56 (SD, 6)
Migraine with insomnia	145	51 (SD, 7)^b	52 (SD, 7)^b	51 (SD, 7)^b	50 (SD, 8)^b	48 (SD, 6)^b
Migraine without depression	166	57 (SD, 8)	59 (SD, 8)	58 (SD, 8)	56 (SD, 8)	53 (SD, 7)
Migraine with depression	76	51 (SD, 8)^b	53 (SD, 8)^b	52 (SD, 8)^b	51 (SD, 8)^b	49 (SD, 7)^c
Migraine without both insomnia and depression	91	62 (SD, 6)	64 (SD, 5)	63 (SD, 5)	60 (SD, 5)	56 (SD, 6)
Migraine with either insomnia or depression	151	51 (SD, 8)^b	53 (SD, 8)^b	52 (SD, 8)^b	50 (SD, 8)^b	49 (SD, 7)^b

Note:—Tha indiates thalamus; AM, anterior part of the territory of the MCA; PM, posterior part of the territory of the MCA.
^aData are means. Insomnia was defined as a score of ≥4 on the AIS. Depression was defined as a score of ≥11 on the BDI-II. The unit for CBF is mL/100 g/min. rCBF data in migraineurs without insomnia (or depression) were compared with those in healthy controls and migraineurs with insomnia (or depression) and evaluated by ANOVA followed by the Tukey honestly significant difference test.
^bP < .001.
^cP = .01.