Ischemic Stroke Thrombus Perviousness is Associated with Distinguishable Proteomic Features and Susceptibility to ADAMTS13-Augmented Thrombolysis

References

1. 1.↵
   1. Wei L,
   2. Zhu Y,
   3. Deng J, et al

   . Visualization of thrombus enhancement on thin-slab maximum intensity projection of CT angiography: an imaging sign for predicting stroke source and thrombus compositions. Radiology 2021;298:374–81 doi:10.1148/radiol.2020201548 pmid:33320066

   CrossRefPubMed
2. 2.↵
   1. Benson JC,
   2. Fitzgerald ST,
   3. Kadirvel R, et al

   . Clot permeability and histopathology: is a clot's perviousness on CT imaging correlated with its histologic composition? J Neurointerv Surg 2020;12:38–42 doi:10.1136/neurintsurg-2019-014979 pmid:31239329

   Abstract/FREE Full Text
3. 3.↵
   1. Patel TR,
   2. Fricano S,
   3. Waqas M, et al

   . Increased perviousness on CT for acute ischemic stroke is associated with fibrin/platelet-rich clots. AJNR Am J Neuroradiol 2021;42:57–64 doi:10.3174/ajnr.A6866 pmid:33243895

   Abstract/FREE Full Text
4. 4.↵
   1. Ye G,
   2. Cao R,
   3. Lu J, et al

   . Histological composition behind CT-based thrombus density and perviousness in acute ischemic stroke. Clin Neurol Neurosurg 2021;207:106804 doi:10.1016/j.clineuro.2021.106804 pmid:34304067

   CrossRefPubMed
5. 5.↵
   1. Staessens S,
   2. François O,
   3. Brinjikji W, et al

   . Studying stroke thrombus composition after thrombectomy: what can we learn? Stroke 2021;52:3718–27 doi:10.1161/STROKEAHA.121.034289 pmid:34517770

   CrossRefPubMed
6. 6.↵
   1. Santos EM,
   2. Marquering HA,
   3. den Blanken MD, et al

   ; MR CLEAN Investigators. Thrombus permeability is associated with improved functional outcome and recanalization in patients with ischemic stroke. Stroke 2016;47:732–41 doi:10.1161/STROKEAHA.115.011187 pmid:26846859

   Abstract/FREE Full Text
7. 7.↵
   1. Mokin M,
   2. Waqas M,
   3. Fifi J, et al

   . Clot perviousness is associated with first pass success of aspiration thrombectomy in the COMPASS trial. J Neurointerv Surg 2021;13:509–14 doi:10.1136/neurintsurg-2020-016434 pmid:32680875

   Abstract/FREE Full Text
8. 8.↵
   1. Chen Z,
   2. Shi F,
   3. Gong X, et al

   . Thrombus permeability on dynamic CTA predicts good outcome after reperfusion therapy. AJNR Am J Neuroradiol 2018;39:1854–59 doi:10.3174/ajnr.A5785 pmid:30166435

   Abstract/FREE Full Text
9. 9.↵
   1. Berndt M,
   2. Friedrich B,
   3. Maegerlein C, et al

   . Thrombus permeability in admission computed tomographic imaging indicates stroke pathogenesis based on thrombus histology. Stroke 2018;49:2674–82 doi:10.1161/STROKEAHA.118.021873 pmid:30355200

   CrossRefPubMed
10. 10.↵
    1. Santos EM,
    2. Yoo AJ,
    3. Beenen LF, et al

    ; MR CLEAN Investigators. Observer variability of absolute and relative thrombus density measurements in patients with acute ischemic stroke. Neuroradiology 2016;58:133–39 doi:10.1007/s00234-015-1607-4 pmid:26494462

    CrossRefPubMed
11. 11.↵
    1. Eden E,
    2. Navon R,
    3. Steinfeld I, et al

    . GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists. BMC Bioinformatics 2009;10:48 doi:10.1186/1471-2105-10-48 pmid:19192299

    CrossRefPubMed
12. 12.↵
    1. Bilgic AB,
    2. Gocmen R,
    3. Arsava EM, et al

    . The effect of clot volume and permeability on response to intravenous tissue plasminogen activator in acute ischemic stroke. J Stroke Cerebrovasc Dis 2020;29:104541 doi:10.1016/j.jstrokecerebrovasdis.2019.104541 pmid:31810719

    CrossRefPubMed
13. 13.↵
    1. Schartz D,
    2. Akkipeddi SM,
    3. Chittaranjan S, et al

    . CT hyperdense cerebral artery sign reflects distinct proteomic composition in acute ischemic stroke thrombus. J Neurointerv Surg 2023;15:1264–68 doi:10.1136/jnis-2022-019937 pmid:36878687

    Abstract/FREE Full Text
14. 14.↵
    1. Marín-Quílez A,
    2. Vuelta E,
    3. Díaz-Ajenjo L, et al

    . A novel nonsense variant in TPM4 caused dominant macrothrombocytopenia, mild bleeding tendency and disrupted cytoskeleton remodeling. J Thromb Haemost 2022;20:1248–55 doi:10.1111/jth.15672 pmid:35170221

    CrossRefPubMed
15. 15.↵
    1. Hampson A,
    2. O’Connor A,
    3. Smolenski A

    . Synaptotagmin-like protein 4 and Rab8 interact and increase dense granule release in platelets. J Thromb Haemost 2013;11:161–68 doi:10.1111/jth.12068 pmid:23140275

    CrossRefPubMed
16. 16.↵
    1. Neumüller O,
    2. Hoffmeister M,
    3. Babica J, et al

    . Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets. Blood 2009;114:1396–404 doi:10.1182/blood-2008-05-155234 pmid:19528539

    Abstract/FREE Full Text
17. 17.↵
    1. McKenzie SE,
    2. Taylor SM,
    3. Malladi P, et al

    . The role of the human Fc receptor Fc gamma RIIA in the immune clearance of platelets: a transgenic mouse model. J Immunol 1999;162:4311–18

    Abstract/FREE Full Text
18. 18.↵
    1. Arman M,
    2. Krauel K

    . Human platelet IgG Fc receptor FcγRIIA in immunity and thrombosis. J Thromb Haemost 2015;13:893–908 doi:10.1111/jth.12905 pmid:25900780

    CrossRefPubMed
19. 19.↵
    1. Martinon F,
    2. Burns K,
    3. Tschopp J

    . The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 2002;10:417–26 doi:10.1016/s1097-2765(02)00599-3 pmid:12191486

    CrossRefPubMedWeb of Science
20. 20.↵
    1. Laguette N,
    2. Sobhian B,
    3. Casartelli N, et al

    . SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx. Nature 2011;474:654–57 doi:10.1038/nature10117 pmid:21613998

    CrossRefPubMedWeb of Science
21. 21.↵
    1. Renedo D,
    2. Sujijantarat N,
    3. Antonios J, et al

    . Single-cell immune landscape of human clot retrieved at mechanical thrombectomy: association with stroke origin. Stroke 2023;54:A15 doi:10.1161/str.54.suppl_1.15

    CrossRef
22. 22.↵
    1. Denorme F,
    2. Langhauser F,
    3. Desender L, et al

    . ADAMTS13-mediated thrombolysis of t-PA-resistant occlusions in ischemic stroke in mice. Blood 2016;127:2337–45 doi:10.1182/blood-2015-08-662650 pmid:26929275

    Abstract/FREE Full Text
23. 23.↵
    1. Brinjikji W,
    2. Abbasi M,
    3. Mereuta OM, et al

    . Histological composition of retrieved emboli in acute ischemic stroke is independent of pre-thrombectomy alteplase use. J Stroke Cerebrovasc Dis 2022;31:106376 doi:10.1016/j.jstrokecerebrovasdis.2022.106376 pmid:35183984

    CrossRefPubMed