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Research ArticleADULT BRAIN

Performance of Automated ASPECTS Software and Value as a Computer-Aided Detection Tool

J. Lambert, J. Demeestere, B. Dewachter, L. Cockmartin, A. Wouters, R. Symons, L. Boomgaert, L. Vandewalle, L. Scheldeman, P. Demaerel and R. Lemmens
American Journal of Neuroradiology July 2023, DOI: https://doi.org/10.3174/ajnr.A7956
J. Lambert
aFrom the Departments of Radiology (J.L., B.D., L.C., R.S., L. B., P.D.)
cDepartments of Imaging and Pathology (J.L., B.D., P.D.)
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J. Demeestere
bNeurology (J.D., L.V., L.S., R.S.), University Hospitals Leuven, Leuven, Belgium
dNeuroscience (J.D., A.W., L.V., L.S., R.L.)
eExperimental Neurology (J.D., A.W., L.V., L.S., R.L.), Laboratory of Neurobiology, Katholieke Universiteit Leuven, University of Leuven, Leuven, Belgium
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B. Dewachter
aFrom the Departments of Radiology (J.L., B.D., L.C., R.S., L. B., P.D.)
cDepartments of Imaging and Pathology (J.L., B.D., P.D.)
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L. Cockmartin
aFrom the Departments of Radiology (J.L., B.D., L.C., R.S., L. B., P.D.)
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A. Wouters
dNeuroscience (J.D., A.W., L.V., L.S., R.L.)
eExperimental Neurology (J.D., A.W., L.V., L.S., R.L.), Laboratory of Neurobiology, Katholieke Universiteit Leuven, University of Leuven, Leuven, Belgium
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R. Symons
aFrom the Departments of Radiology (J.L., B.D., L.C., R.S., L. B., P.D.)
bNeurology (J.D., L.V., L.S., R.S.), University Hospitals Leuven, Leuven, Belgium
fImelda Hospital (R.S.), Bonheiden, Belgium
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L. Boomgaert
aFrom the Departments of Radiology (J.L., B.D., L.C., R.S., L. B., P.D.)
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L. Vandewalle
bNeurology (J.D., L.V., L.S., R.S.), University Hospitals Leuven, Leuven, Belgium
dNeuroscience (J.D., A.W., L.V., L.S., R.L.)
eExperimental Neurology (J.D., A.W., L.V., L.S., R.L.), Laboratory of Neurobiology, Katholieke Universiteit Leuven, University of Leuven, Leuven, Belgium
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L. Scheldeman
bNeurology (J.D., L.V., L.S., R.S.), University Hospitals Leuven, Leuven, Belgium
dNeuroscience (J.D., A.W., L.V., L.S., R.L.)
eExperimental Neurology (J.D., A.W., L.V., L.S., R.L.), Laboratory of Neurobiology, Katholieke Universiteit Leuven, University of Leuven, Leuven, Belgium
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P. Demaerel
aFrom the Departments of Radiology (J.L., B.D., L.C., R.S., L. B., P.D.)
cDepartments of Imaging and Pathology (J.L., B.D., P.D.)
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R. Lemmens
dNeuroscience (J.D., A.W., L.V., L.S., R.L.)
eExperimental Neurology (J.D., A.W., L.V., L.S., R.L.), Laboratory of Neurobiology, Katholieke Universiteit Leuven, University of Leuven, Leuven, Belgium
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  • FIG 1.
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    FIG 1.

    Scatterplots with trendlines of individual raters and automated software (x-axis) versus the criterion standard (y-axis). The size of each dot is proportionate to the number of cases with that combination of scores. R indicates rater.

  • FIG 2.
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    FIG 2.

    Score distribution plots illustrating the improvement of the interrater agreement of the 5 raters without (A) and with (B) CAD. The intraclass correlation coefficient of the raters was 0.55 (95% CI, 0.48–0.62) without CAD compared with 0.73 (95% CI, 0.68–0.78) with CAD. IQR indicates interquartile range.

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    Table 1:

    Patient characteristics

    Characteristics
    No. of patients174
    Age (yr)a72 (33–96)
    Female sex (%)94 (54%)
    NIHSSb18 (13–22)
    Time from symptom onset to imaging (min)a161 (5–1503)
    No. of patients with known time interval from symptom onset to imaging173
    0–1 hour46 (27%)
    1–2 hours71 (41%)
    2–6 hours40 (23%)
    >6 hours16 (9%)
    NCCT acquired at referral hospital (%)50 (29%)
    • ↵a Data are mean (range).

    • ↵b Data are median (intequartile range).

    • View popup
    Table 2:

    ASPECTS ratings overview with medians, interquartile ranges, and dichotomized score proportions

    RatersMedian (IQR)0–56–10
    Criterion standard8 (7–10)14%86%
    RAPID ASPECTS7 (6–9)17%83%
    Rater 19 (8–9)7%93%
    Rater 1 with CAD8 (7–9)9%91%
    Rater 28 (6–10)17%83%
    Rater 2 with CAD8 (6–10)19%81%
    Rater 39 (8–10)8%92%
    Rater 3 with CAD8 (7–10)12%88%
    Rater 49 (7–10)11%89%
    Rater 4 with CAD8 (7–10)14%86%
    Rater 58 (7–10)11%89%
    Rater 5 with CAD8 (6–9)18%82%
    • Note:—IQR indicates interquartile range.

    • View popup
    Table 3:

    Impact of time from onset to imaging on ASPECTS

    Paired Agreement0–1 Hour1–2 Hours2–6 HoursP Value
    Rater 1 versus criterion standard0.260.410.54.10
    Rater 2 versus criterion standard0.380.420.32.77
    Rater 3 versus criterion standard0.270.340.58.03
    Rater 4 versus criterion standard0.720.680.84.04
    Rater 5 versus criterion standard0.550.460.50.71
    Automated ASPECTS versus criterion standard0.370.660.67.002
    • Note:—Data are weighted κ values.

    • View popup
    Table 4:

    Overall scores agreement with the expert criterion standard for readings without and with CAD

    Overall ScoresWeighted κ without CADWeighted κ with CADP Value
    Rater 1 versus criterion standard0.41 (0.04)0.58 (0.03)<.001
    Rater 2 versus criterion standard0.38 (0.05)0.52 (0.05).001
    Rater 3 versus criterion standard0.42 (0.04)0.68 (0.03)<.001
    Rater 4 versus criterion standard0.76 (0.03)0.84 (0.02)<.001
    Rater 5 versus criterion standard0.49 (0.04)0.57 (0.04).04
    • Note:—Standard errors of the κ coefficients are in parentheses.

    • View popup
    Table 5:

    Dichotomized scores agreement with the criterion standard for readings without and with CAD

    Dichotomized ScoresCohen κ without CADCohen κ with CADP Value
    Rater 1 versus criterion standard0.43 (0.11)0.61 (0.09).12
    Rater 2 versus criterion standard0.42 (0.09)0.63 (0.08).02
    Rater 3 versus criterion standard0.40 (0.10)0.55 (0.09).19
    Rater 4 versus criterion standard0.74 (0.08)0.86 (0.06).07
    Rater 5 versus criterion standard0.43 (0.10)0.58 (0.09).14
    • Note:—Standard errors of the κ coefficients are in parentheses.

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Cite this article
J. Lambert, J. Demeestere, B. Dewachter, L. Cockmartin, A. Wouters, R. Symons, L. Boomgaert, L. Vandewalle, L. Scheldeman, P. Demaerel, R. Lemmens
Performance of Automated ASPECTS Software and Value as a Computer-Aided Detection Tool
American Journal of Neuroradiology Jul 2023, DOI: 10.3174/ajnr.A7956

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Performance of Automated ASPECTS Software and Value as a Computer-Aided Detection Tool
J. Lambert, J. Demeestere, B. Dewachter, L. Cockmartin, A. Wouters, R. Symons, L. Boomgaert, L. Vandewalle, L. Scheldeman, P. Demaerel, R. Lemmens
American Journal of Neuroradiology Jul 2023, DOI: 10.3174/ajnr.A7956
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